Condensed Consolidated Statements of Stockholders’ Equity (Unaudited) - USD ($) $ in Thousands |
Total |
At-The-Market Offering |
Follow-On Offering |
License And Collaboration Agreement |
Common Stock |
Common Stock
At-The-Market Offering
|
Common Stock
Follow-On Offering
|
Common Stock
License And Collaboration Agreement
|
Additional Paid-In Capital |
Additional Paid-In Capital
At-The-Market Offering
|
Additional Paid-In Capital
Follow-On Offering
|
Additional Paid-In Capital
License And Collaboration Agreement
|
Accumulated Deficit |
Accumulated Other Comprehensive Gain (Loss) |
Beginning balance (in shares) at Dec. 31, 2023 |
|
|
|
|
8,791,877
|
|
|
|
|
|
|
|
|
|
Beginning balance at Dec. 31, 2023 |
$ 69,669
|
|
|
|
$ 13
|
|
|
|
$ 723,577
|
|
|
|
$ (653,921)
|
$ 0
|
Increase (Decrease) in Stockholders' Equity [Roll Forward] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Stock-based compensation expense |
14,475
|
|
|
|
|
|
|
|
14,475
|
|
|
|
|
|
Issuance of common stock (in shares) |
|
|
|
|
|
209,852
|
3,802,025
|
443,253
|
|
|
|
|
|
|
Issuance of common stock |
|
$ 6,169
|
$ 161,649
|
$ 17,265
|
|
|
|
|
|
$ 6,169
|
$ 161,649
|
$ 17,265
|
|
|
Vesting of restricted stock awards (in shares) |
|
|
|
|
11,095
|
|
|
|
|
|
|
|
|
|
Shares withheld for taxes for vesting of restricted stock units (in shares) |
|
|
|
|
(3,689)
|
|
|
|
|
|
|
|
|
|
Shares withheld for taxes for vesting of restricted stock units |
(137)
|
|
|
|
|
|
|
|
(137)
|
|
|
|
|
|
Issuance of common stock upon exercise of stock options (in shares) |
|
|
|
|
3,634
|
|
|
|
|
|
|
|
|
|
Issuance of common stock upon exercise of stock options |
143
|
|
|
|
|
|
|
|
143
|
|
|
|
|
|
Change in unrealized gain on marketable securities, net of tax |
3
|
|
|
|
|
|
|
|
|
|
|
|
|
3
|
Net loss |
(39,553)
|
|
|
|
|
|
|
|
|
|
|
|
(39,553)
|
|
Ending balance (in shares) at Mar. 31, 2024 |
|
|
|
|
13,258,047
|
|
|
|
|
|
|
|
|
|
Ending balance at Mar. 31, 2024 |
229,683
|
|
|
|
$ 13
|
|
|
|
923,141
|
|
|
|
(693,474)
|
3
|
Beginning balance (in shares) at Dec. 31, 2023 |
|
|
|
|
8,791,877
|
|
|
|
|
|
|
|
|
|
Beginning balance at Dec. 31, 2023 |
69,669
|
|
|
|
$ 13
|
|
|
|
723,577
|
|
|
|
(653,921)
|
0
|
Increase (Decrease) in Stockholders' Equity [Roll Forward] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Change in unrealized gain on marketable securities, net of tax |
(71)
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Net loss |
(72,230)
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Ending balance (in shares) at Jun. 30, 2024 |
|
|
|
|
17,755,506
|
|
|
|
|
|
|
|
|
|
Ending balance at Jun. 30, 2024 |
419,100
|
|
|
|
$ 14
|
|
|
|
1,145,308
|
|
|
|
(726,151)
|
(71)
|
Beginning balance (in shares) at Dec. 31, 2023 |
|
|
|
|
8,791,877
|
|
|
|
|
|
|
|
|
|
Beginning balance at Dec. 31, 2023 |
$ 69,669
|
|
|
|
$ 13
|
|
|
|
723,577
|
|
|
|
(653,921)
|
0
|
Ending balance (in shares) at Dec. 31, 2024 |
19,422,358
|
|
|
|
19,422,358
|
|
|
|
|
|
|
|
|
|
Ending balance at Dec. 31, 2024 |
$ 445,450
|
|
|
|
$ 14
|
|
|
|
1,281,522
|
|
|
|
(836,740)
|
654
|
Beginning balance (in shares) at Mar. 31, 2024 |
|
|
|
|
13,258,047
|
|
|
|
|
|
|
|
|
|
Beginning balance at Mar. 31, 2024 |
229,683
|
|
|
|
$ 13
|
|
|
|
923,141
|
|
|
|
(693,474)
|
3
|
Increase (Decrease) in Stockholders' Equity [Roll Forward] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Stock-based compensation expense |
5,878
|
|
|
|
|
|
|
|
5,878
|
|
|
|
|
|
Issuance of common stock (in shares) |
|
|
|
|
|
|
3,849,558
|
|
|
|
|
|
|
|
Issuance of common stock |
|
|
$ 215,988
|
|
|
|
$ 1
|
|
|
|
$ 215,987
|
|
|
|
Issuance of common stock under employee stock purchase plan (in shares) |
|
|
|
|
25,146
|
|
|
|
|
|
|
|
|
|
Issuance of common stock under employee stock purchase plan |
311
|
|
|
|
|
|
|
|
311
|
|
|
|
|
|
Issuance of common stock from exercise of pre-funded warrants (in shares) |
|
|
|
|
622,123
|
|
|
|
|
|
|
|
|
|
Vesting of restricted stock awards (in shares) |
|
|
|
|
726
|
|
|
|
|
|
|
|
|
|
Shares withheld for taxes for vesting of restricted stock units (in shares) |
|
|
|
|
(242)
|
|
|
|
|
|
|
|
|
|
Shares withheld for taxes for vesting of restricted stock units |
(13)
|
|
|
|
|
|
|
|
(13)
|
|
|
|
|
|
Issuance of common stock upon exercise of stock options (in shares) |
|
|
|
|
148
|
|
|
|
|
|
|
|
|
|
Issuance of common stock upon exercise of stock options |
4
|
|
|
|
|
|
|
|
4
|
|
|
|
|
|
Change in unrealized gain on marketable securities, net of tax |
(74)
|
|
|
|
|
|
|
|
|
|
|
|
|
(74)
|
Net loss |
(32,677)
|
|
|
|
|
|
|
|
|
|
|
|
(32,677)
|
|
Ending balance (in shares) at Jun. 30, 2024 |
|
|
|
|
17,755,506
|
|
|
|
|
|
|
|
|
|
Ending balance at Jun. 30, 2024 |
$ 419,100
|
|
|
|
$ 14
|
|
|
|
1,145,308
|
|
|
|
(726,151)
|
(71)
|
Beginning balance (in shares) at Dec. 31, 2024 |
19,422,358
|
|
|
|
19,422,358
|
|
|
|
|
|
|
|
|
|
Beginning balance at Dec. 31, 2024 |
$ 445,450
|
|
|
|
$ 14
|
|
|
|
1,281,522
|
|
|
|
(836,740)
|
654
|
Increase (Decrease) in Stockholders' Equity [Roll Forward] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Stock-based compensation expense |
8,786
|
|
|
|
|
|
|
|
8,786
|
|
|
|
|
|
Issuance of common stock (in shares) |
|
|
|
|
|
694,212
|
|
|
|
|
|
|
|
|
Issuance of common stock |
|
54,904
|
|
|
|
|
|
|
|
54,904
|
|
|
|
|
Issuance of common stock from exercise of pre-funded warrants (in shares) |
|
|
|
|
173,840
|
|
|
|
|
|
|
|
|
|
Vesting of restricted stock awards (in shares) |
|
|
|
|
55,850
|
|
|
|
|
|
|
|
|
|
Shares withheld for taxes for vesting of restricted stock units (in shares) |
|
|
|
|
(18,765)
|
|
|
|
|
|
|
|
|
|
Shares withheld for taxes for vesting of restricted stock units |
(1,195)
|
|
|
|
|
|
|
|
(1,195)
|
|
|
|
|
|
Issuance of common stock upon exercise of stock options (in shares) |
|
|
|
|
14,422
|
|
|
|
|
|
|
|
|
|
Issuance of common stock upon exercise of stock options |
560
|
|
|
|
|
|
|
|
560
|
|
|
|
|
|
Change in unrealized gain on marketable securities, net of tax |
5
|
|
|
|
|
|
|
|
|
|
|
|
|
5
|
Net loss |
(69,296)
|
|
|
|
|
|
|
|
|
|
|
|
(69,296)
|
|
Ending balance (in shares) at Mar. 31, 2025 |
|
|
|
|
20,341,917
|
|
|
|
|
|
|
|
|
|
Ending balance at Mar. 31, 2025 |
$ 439,214
|
|
|
|
$ 14
|
|
|
|
1,344,577
|
|
|
|
(906,036)
|
659
|
Beginning balance (in shares) at Dec. 31, 2024 |
19,422,358
|
|
|
|
19,422,358
|
|
|
|
|
|
|
|
|
|
Beginning balance at Dec. 31, 2024 |
$ 445,450
|
|
|
|
$ 14
|
|
|
|
1,281,522
|
|
|
|
(836,740)
|
654
|
Increase (Decrease) in Stockholders' Equity [Roll Forward] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Issuance of common stock upon exercise of stock options (in shares) |
14,422
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Change in unrealized gain on marketable securities, net of tax |
$ (259)
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Net loss |
$ (140,423)
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Ending balance (in shares) at Jun. 30, 2025 |
21,040,474
|
|
|
|
21,040,474
|
|
|
|
|
|
|
|
|
|
Ending balance at Jun. 30, 2025 |
$ 404,224
|
|
|
|
$ 14
|
|
|
|
1,380,978
|
|
|
|
(977,163)
|
395
|
Beginning balance (in shares) at Mar. 31, 2025 |
|
|
|
|
20,341,917
|
|
|
|
|
|
|
|
|
|
Beginning balance at Mar. 31, 2025 |
439,214
|
|
|
|
$ 14
|
|
|
|
1,344,577
|
|
|
|
(906,036)
|
659
|
Increase (Decrease) in Stockholders' Equity [Roll Forward] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Stock-based compensation expense |
7,770
|
|
|
|
|
|
|
|
7,770
|
|
|
|
|
|
Issuance of common stock (in shares) |
|
|
|
|
|
657,477
|
|
|
|
|
|
|
|
|
Issuance of common stock |
|
$ 28,360
|
|
|
|
|
|
|
|
28,360
|
|
|
|
|
Issuance of common stock under employee stock purchase plan (in shares) |
|
|
|
|
9,319
|
|
|
|
|
|
|
|
|
|
Issuance of common stock under employee stock purchase plan |
294
|
|
|
|
|
|
|
|
|
$ 294
|
|
|
|
|
Issuance of common stock from exercise of pre-funded warrants (in shares) |
|
|
|
|
26,509
|
|
|
|
|
|
|
|
|
|
Vesting of restricted stock awards (in shares) |
|
|
|
|
5,860
|
|
|
|
|
|
|
|
|
|
Shares withheld for taxes for vesting of restricted stock units (in shares) |
|
|
|
|
(608)
|
|
|
|
|
|
|
|
|
|
Shares withheld for taxes for vesting of restricted stock units |
(23)
|
|
|
|
|
|
|
|
(23)
|
|
|
|
|
|
Change in unrealized gain on marketable securities, net of tax |
(264)
|
|
|
|
|
|
|
|
|
|
|
|
|
(264)
|
Net loss |
$ (71,127)
|
|
|
|
|
|
|
|
|
|
|
|
(71,127)
|
|
Ending balance (in shares) at Jun. 30, 2025 |
21,040,474
|
|
|
|
21,040,474
|
|
|
|
|
|
|
|
|
|
Ending balance at Jun. 30, 2025 |
$ 404,224
|
|
|
|
$ 14
|
|
|
|
$ 1,380,978
|
|
|
|
$ (977,163)
|
$ 395
|