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Reference 8: http://fasb.org/us-gaap/role/ref/legacyRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SX 210.3-04)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480008/505-10-S99-1

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Stockholders' Equity - Additional Information (Details)	1 Months Ended				3 Months Ended			6 Months Ended
Stockholders' Equity - Additional Information (Details)	May 31, 2025 USD ($) $ / shares shares	Feb. 28, 2025	Jul. 31, 2023 USD ($) $ / shares shares	Dec. 31, 2022 USD ($)	Jun. 30, 2025 USD ($) $ / shares shares	Mar. 31, 2025 shares	Jun. 30, 2024 USD ($) shares	Jun. 30, 2025 USD ($) $ / shares shares	Jun. 30, 2024 USD ($)
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Expected cash dividend								$ 0
Expense					$ 24,611,000		$ 21,382,000	47,919,000	$ 41,572,000
Stock-based compensation expense capitalized					300,000		$ 300,000	700,000	700,000
Proceeds from Issuance of Common Stock								$ 52,283,000	$ 11,264,000
Weighted average grant date fair value \| $ / shares								$ 89.21
Unrecognized compensation cost related to unvested stock options expected to be recognized					$ 133,800,000			$ 133,800,000
Expected vesting period for unvested share-based compensation								2 years 2 months 12 days
Common Stock
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Issuance of common stock \| shares					306,486	156,484	148,875
Restricted Stock Units
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Vesting period								4 years
Compensation cost not yet recognized related to nonvested RSUs					$ 80,300,000			$ 80,300,000
Weighted average contractual term								2 years 9 months 18 days
Intrinsic value lapsed					14,700,000			$ 14,700,000
Performance Stock Units
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Vesting period								3 years
Compensation cost not yet recognized related to nonvested RSUs					$ 5,400,000			$ 5,400,000
Weighted average contractual term								2 years 8 months 12 days
2015 Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares available for future grant \| shares					2,456,958			2,456,958
June 2023 Public Offering
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Proceeds from Issuance of Common Stock			$ 31,700,000					$ 211,300,000
Underwriting discounts and commissions			$ 2,000,000		$ 13,500,000			13,500,000
Other offering costs								$ 200,000
June 2023 Public Offering \| Common Stock
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share Price \| $ / shares			$ 75		$ 75			$ 75
Issuance of common stock \| shares			450,000					3,000,000
Employee Stock Purchase Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares issued \| shares								59,607
Purchase price of common stock percent								85.00%
Expense					$ 500,000			$ 800,000
March 2022 Sales Agreement
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Proceeds from issuance of common stock, gross					$ 17,600,000			$ 37,300,000
Shares issued \| shares					166,486			322,970
Proceeds from issuance of common stock, net					$ 17,200,000			$ 36,500,000
Blackstone Securities Purchase Agreement \| Private Placement
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Proceeds from issuance of common stock, gross	$ 15,000,000
Blackstone Securities Purchase Agreement \| Private Placement \| Common Stock
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares issued \| shares	140,000
Share Price \| $ / shares	$ 107.14
Maximum \| Performance Stock Units
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Payout multiplier ratio		2
Maximum \| Leerink \| March 2022 Sales Agreement
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Common stock sales agreement, authorized amount				$ 250,000,000
Minimum \| Performance Stock Units
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Payout multiplier ratio		0