In 2023 we initiated cost saving measures as part of our Fit for Growth program to reduce operating costs, while improving operating efficiency and effectiveness. The Fit for Growth program is expected to generate approximately $1.0 billion in gross operating expense savings by the end of 2025, some of which will be reinvested in various initiatives. The Fit for Growth program is currently estimated to include net headcount reductions of approximately 1,400 employees and we expect to incur total restructuring charges ranging from approximately $300.0 million to $310.0 million. As of June 30, 2025, cumulative total restructuring charges incurred in connection with our Fit for Growth program totaled approximately $300.0 million.


	For the Three Months Ended June 30,
	2025						2024
(In millions)	Severance Costs		Accelerated Depreciation and Other Costs		Total		Severance Costs		Accumulated Depreciation and Other Costs		Total
Selling, general and administrative	$	—	$	0.7	$	0.7	$	—	$	2.0	$	2.0
Research and development	—		1.3		1.3		—		2.2		2.2
Restructuring charges	(1.1)		—		(1.1)		6.3		—		6.3
Total charges	$	(1.1)	$	2.0	$	0.9	$	6.3	$	4.2	$	10.5

	For the Six Months Ended June 30,
	2025						2024
(In millions)	Severance Costs		Accelerated Depreciation and Other Costs		Total		Severance Costs		Accumulated Depreciation and Other Costs		Total
Selling, general and administrative	$	—	$	(3.2)	$	(3.2)	$	—	$	3.4	$	3.4
Research and development	—		6.4		6.4		—		7.1		7.1
Restructuring charges	34.2		—		34.2		15.6		—		15.6
Total charges	$	34.2	$	3.2	$	37.4	$	15.6	$	10.5	$	26.1

Other Costs: Includes costs associated with items such as asset abandonment and write-offs, facility closure costs, pre-tax gains and losses resulting from the termination of certain leases, employee non-severance expense, consulting fees and other costs.

Following the close of our Reata acquisition in September 2023, we implemented an integration plan designed to realize operating synergies through cost savings and avoidance. Under this initiative, we estimate we will incur total integration charges of approximately $35.0 million related to severance and employment costs. These severance and employment costs were substantially incurred during 2023.


	For the Three Months Ended June 30,
	2025						2024
(In millions)	Severance Costs		Accelerated Depreciation and Other Costs		Total		Severance Costs		Accumulated Depreciation and Other Costs		Total
Selling, general and administrative	$	—	$	1.8	$	1.8	$	—	$	1.5	$	1.5
Research and development	—		4.0		4.0		—		3.3		3.3
Restructuring charges	—		—		—		0.3		—		0.3
Total charges	$	—	$	5.8	$	5.8	$	0.3	$	4.8	$	5.1

	For the Six Months Ended June 30,
	2025						2024
(In millions)	Severance Costs		Accelerated Depreciation and Other Costs		Total		Severance Costs		Accumulated Depreciation and Other Costs		Total
Selling, general and administrative	$	—	$	3.6	$	3.6	$	—	$	3.3	$	3.3
Research and development	—		6.3		6.3		—		6.0		6.0
Restructuring charges	(0.2)		—		(0.2)		2.5		—		2.5
Total charges	$	(0.2)	$	9.9	$	9.7	$	2.5	$	9.3	$	11.8

In connection with our acquisition of Reata we assumed responsibility for a single-tenant, build-to-suit building of approximately 327,400 square feet of office and laboratory space located in Plano, Texas, with an initial lease term of 16 years. We do not intend to occupy this building and are evaluating opportunities to sublease the property. For additional information on our acquisition of Reata, please read Note 2, Acquisitions, to our consolidated financial statements included in our 2024 Form 10-K.


	Workforce Reductions
(In millions)	2025		2024

Restructuring reserve as of January 1	$	31.9		$	75.4
Expense	35.3			11.5
Payment	(25.8)			(42.2)
Foreign currency and other adjustments	(1.0)			0.8
Restructuring reserve as of March 31	40.4			45.5
Expense	(0.7)			6.6
Payment	(9.5)			(11.9)
Foreign currency and other adjustments	(1.0)			—
Restructuring reserve as of June 30	$	29.2		$	40.2