v3.25.2
Segment Information (Details)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2025
USD ($)
Mar. 31, 2025
USD ($)
Jun. 30, 2024
USD ($)
Mar. 31, 2024
USD ($)
Jun. 30, 2025
USD ($)
segment
Jun. 30, 2024
USD ($)
Segment Reporting [Abstract]            
Number of operating segments | segment         1  
Segment Reporting Information [Line Items]            
Product revenue, net $ 12,455   $ 8,615   $ 21,181 $ 16,804
PK activator (PYRUKYND®) direct expenses - research and development (91,940)   (77,401)   (164,683) (146,021)
Total selling, general and administrative expenses (45,869)   (35,536)   (87,396) (66,550)
Net loss (112,020) $ (89,289) (96,118) $ (81,549) (201,309) (177,667)
Reportable Segment            
Segment Reporting Information [Line Items]            
PK activator (PYRUKYND®) direct expenses - research and development (29,809)   (27,968)   (51,130) (54,004)
Compensation and related expenses - research and development (27,594)   (27,476)   (60,584) (55,110)
Total selling, general and administrative expenses (45,869)   (35,536)   (87,396) (66,550)
Other segment expenses (21,203)   (13,753)   (23,380) (18,807)
Net loss (112,020)   (96,118)   (201,309) (177,667)
Product revenue, net            
Segment Reporting Information [Line Items]            
Product revenue, net 12,455   8,615   21,181 16,804
Product revenue, net | Reportable Segment            
Segment Reporting Information [Line Items]            
Product revenue, net $ 12,455   $ 8,615   $ 21,181 $ 16,804