Note 5 - Composition of Certain Financial Statement Captions - Schedule of Goodwill (Details) $ in Thousands	6 Months Ended
Jun. 30, 2025 USD ($)
Goodwill, gross	$ 567,275
Goodwill, impairment	(38,023)
Goodwill, acquired (disposed of)	(56,265)
Goodwill, foreign exchange effect	11,198
Goodwill	484,185
Pharmaceutical [Member] \| CURNA [Member]
Goodwill, gross	4,827
Goodwill, impairment	(4,827)
Goodwill, acquired (disposed of)	0
Goodwill, foreign exchange effect	0
Goodwill	0
Pharmaceutical [Member] \| Rayaldee [Member]
Goodwill, gross	79,433
Goodwill, impairment	0
Goodwill, acquired (disposed of)	0
Goodwill, foreign exchange effect	10,099
Goodwill	89,532
Pharmaceutical [Member] \| FineTech [Member]
Goodwill, gross	11,698
Goodwill, impairment	(11,698)
Goodwill, acquired (disposed of)	0
Goodwill, foreign exchange effect	0
Goodwill	0
Pharmaceutical [Member] \| ModeX Therapeutics, Inc [Member]
Goodwill, gross	80,260
Goodwill, impairment	0
Goodwill, acquired (disposed of)	0
Goodwill, foreign exchange effect	0
Goodwill	80,260
Pharmaceutical [Member] \| OPKO Biologics [Member]
Goodwill, gross	139,784
Goodwill, impairment	0
Goodwill, acquired (disposed of)	0
Goodwill, foreign exchange effect	(0)
Goodwill	139,784
Pharmaceutical [Member] \| OPKO Chile [Member]
Goodwill, gross	3,220
Goodwill, impairment	0
Goodwill, acquired (disposed of)	0
Goodwill, foreign exchange effect	205
Goodwill	3,425
Pharmaceutical [Member] \| OPKO Health Europe [Member]
Goodwill, gross	6,848
Goodwill, impairment	0
Goodwill, acquired (disposed of)	0
Goodwill, foreign exchange effect	894
Goodwill	7,742
Pharmaceutical [Member] \| OPKO Mexico [Member]
Goodwill, gross	100
Goodwill, impairment	(100)
Goodwill, acquired (disposed of)	0
Goodwill, foreign exchange effect	0
Goodwill	0
Pharmaceutical [Member] \| Transition Therapeutics [Member]
Goodwill, gross	3,421
Goodwill, impairment	(3,421)
Goodwill, acquired (disposed of)	0
Goodwill, foreign exchange effect	0
Goodwill	0
Diagnostics [Member]
Goodwill	163,400
Diagnostics [Member] \| BioReference [Member]
Goodwill, gross	219,707
Goodwill, impairment	0
Goodwill, acquired (disposed of)	(56,265)
Goodwill, foreign exchange effect	0
Goodwill	163,442
Diagnostics [Member] \| OPKO Diagnostics [Member]
Goodwill, gross	17,977
Goodwill, impairment	(17,977)
Goodwill, acquired (disposed of)	0
Goodwill, foreign exchange effect	0
Goodwill	$ 0

Represents the amount of goodwill acquired (disposed of) during the period.

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