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Collaboration Agreements - Additional Information (Detail) - USD ($)			3 Months Ended		6 Months Ended		12 Months Ended	30 Months Ended
	Jan. 27, 2023	Dec. 13, 2022	Jun. 30, 2025	Jun. 30, 2024	Jun. 30, 2025	Jun. 30, 2024	Dec. 31, 2023	Jun. 30, 2025	Dec. 31, 2024
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Collaboration and license agreement, deferred revenue noncurrent			$ 4,232,000		$ 4,232,000			$ 4,232,000	$ 6,099,000
Shares issued under equity agreement		10,683,761
Investment, Type [Extensible Enumeration]		G S K Equity Investment [Member]
Purchase price per share		$ 4.68
Net proceeds from sale of ordinary shares						$ 14,038,000
Collaboration revenue recognized			8,699,000	$ 19,692,000	17,874,000	32,230,000
Collaboration and license agreement, deferred revenue current			51,582,000		51,582,000			51,582,000	65,972,000
GSK Collaboration Agreement [Member]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Upfront payment under collaboration agreement	$ 120,000,000	$ 120,000,000
Collaboration Agreement in Premium		15,400,000
Collaboration and license agreement, deferred revenue noncurrent			4,200,000		4,200,000			4,200,000	6,100,000
Aggregate initiation payment		$ 12,000,000
Milestone payment							$ 20,000,000
Collaboration revenue recognized			8,700,000	19,100,000	17,900,000	31,400,000		121,100,000
Collaboration and license agreement, deferred revenue			55,800,000		55,800,000			55,800,000	72,100,000
Collaboration and license agreement, deferred revenue current			51,600,000		51,600,000			$ 51,600,000	$ 66,000,000
Collaboration And License Agreement [Member] \| Takeda [Member]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Collaboration revenue recognized			$ 0	$ 600,000	$ 0	$ 800,000