v3.25.2
UNAUDITED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2025
Jun. 30, 2024
Cash flows from operating activities    
Net loss $ (81,356) $ (121,917)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 8,157 5,299
Amortization of discount on investment securities (4,163) (6,672)
Share-based compensation expense 9,494 14,071
Royalty financing agreement interest expense, net of interest paid 20,626 22,172
Deferred tax expense 921 1,604
Changes in fair value of contingent consideration 3,470 (1,621)
Unrealized foreign exchange (gains) / losses, net (25,163) 2,940
Provision for inventory write-downs   5,839
Other items, net (3,651) 1,681
Changes in operating assets and liabilities:    
Accounts receivable, prepaid expenses, and other current assets and receivables (6,761) (7,227)
Inventories   (2,606)
Accounts payable (2,297) (1,619)
Accrued expenses, other liabilities, and operating leases (3,272) (5,230)
Net cash used in operating activities (83,995) (93,286)
Cash flows from investing activities    
Proceeds on maturity of debt securities 213,763 297,806
Investment in debt securities (120,205) (152,936)
Purchases of property, plant, and equipment (386) (2,948)
Net cash generated from investing activities 93,172 141,922
Cash flows from financing activities    
Proceeds from public offering of shares in connection with follow on, net of issuance costs 80,511  
Proceeds from issuance of ordinary shares related to employee stock option and purchase plans 203 50
Net cash generated from financing activities 80,714 50
Currency effect on cash, cash equivalents and restricted cash 5,052 (2,191)
Net increase in cash, cash equivalents and restricted cash 94,943 46,495
Cash, cash equivalents and restricted cash at beginning of period 160,329 244,544
Cash, cash equivalents and restricted cash at the end of period 255,272 291,039
Cash and cash equivalents 253,778 287,877
Restricted cash related to leasehold and other deposits 1,494 3,162
Total cash, cash equivalents and restricted cash 255,272 291,039
Supplemental cash flow disclosures:    
Cash paid for interest (9,652) (9,261)
Non-cash decrease in accounts payables and accrued expenses and other current liabilities related to purchases of property, plant, and equipment $ (95) $ (458)