Basis of preparation and accounting policies (Details) - USD ($) $ in Millions |
3 Months Ended | 6 Months Ended | |||
|---|---|---|---|---|---|
Jun. 30, 2025 |
Jun. 30, 2024 |
Jun. 30, 2025 |
Jun. 30, 2024 |
Dec. 31, 2024 |
|
| Disclosure of detailed information about borrowings [line items] | |||||
| Product revenue | $ 14,449 | $ 12,934 | $ 27,963 | $ 25,568 | |
| Alliance revenue | 654 | 482 | 1,293 | 939 | |
| Borrowings | 32,839 | 32,839 | $ 30,295 | ||
| Going concern | |||||
| Financial resources | 11,900 | 11,900 | |||
| Cash and cash equivalents | 7,058 | $ 6,916 | 7,058 | $ 6,916 | $ 5,488 |
| Undrawn committed bank facilities | 4,900 | 4,900 | |||
| Due within one year | |||||
| Disclosure of detailed information about borrowings [line items] | |||||
| Borrowings | $ 6,900 | $ 6,900 | |||