v3.25.2
Pay vs Performance Disclosure - USD ($)
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Pay vs Performance Disclosure        
Pay vs Performance Disclosure, Table
In accordance with rules adopted by the Securities and Exchange Commission pursuant to the Dodd-Frank Wall Street Reform and Consumer Protection Act of 2010, we provide the following disclosure regarding executive compensation for our principal executive officer (“PEO”) and
Non-PEO
NEOs and Company performance for the fiscal years listed below. For the most recently completed fiscal year, we did not use any financial performance measure to link Compensation Actually Paid to our NEOs to the Company’s performance; accordingly, this disclosure does not present a company-selected measure in the table below nor a tabular list of our most important performance measures, as permitted under the rules promulgated by the Securities and Exchange Commission.
 
Year
    Summary
Compensation
Table Total for
PEO
1

($)		      Compensation
Actually Paid to
PEO
1, 2, 3

($)		      Average
Summary
Compensation
Table Total for
Non-PEO

NEOs
1

($)		      Average
Compensation
Actually Paid to
Non-PEO

NEOs
1,2,3

($)		      Value of Initial Fixed
$100 Investment
based on
4
      Net Income
($ Millions)		  
   TSR
($)		      Peer Group
TSR
($)		  
2024
      4,272,299        17,389,937        1,790,789        6,201,653        157.18        34.94        (97.0 ) 
2023
      3,874,300        2,219,787        1,740,206        1,235,658        64.17        41.97        (57.5 ) 
2022
      2,667,997        6,079,613        1,190,292        2,247,169        88.95        46.36        (161.8 ) 
2021
      3,892,610        1,265,141        1,530,003        519,760        39.90        76.00        (122.2 ) 
 
1.
Paul Bolno, M.D., MBA was our PEO for each year presented. The individuals comprising the
Non-PEO
NEOs for each year presented are listed below.
 
2021
  
2022
  
2023
  
2024
Michael Panzara, M.D., MPH
   Kyle Moran, CFA   Kyle Moran, CFA   Christopher Francis, Ph.D.
Chandra Vargeese, Ph.D.
   Chandra Vargeese, Ph.D.   Chandra Vargeese, Ph.D.   Kyle Moran, CFA
      Chandra Vargeese, Ph.D.
 
2.
The amounts shown for Compensation Actually Paid have been calculated in accordance with Item 402(v) of Regulation
S-K
and do not reflect compensation actually earned, realized, or received by the Company’s NEOs. These amounts reflect the Summary Compensation Table Total with certain adjustments as described in footnote 3 below.
 
3.
Compensation Actually Paid reflects the exclusions and inclusions of certain amounts for the PEO and the
Non-PEO
NEOs as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718. Amounts in the Exclusion of Stock and Option Awards column are the totals from the Option Awards column set forth in the Summary Compensation Table.
 
Year
    Summary Compensation
Table Total for PEO
($)		    Exclusion of Stock and
Option Awards for PEO
($)		    Inclusion of Equity
Values for PEO
($)		    Compensation Actually
Paid to PEO
($)
2024
        4,272,299        (3,064,934 )        16,182,572        17,389,937
 
Year
    Average Summary
Compensation Table
Total for
Non-PEO

NEOs
($)		    Average Exclusion of
Stock and Option
Awards for Non-PEO

NEOs
($)		    Average Inclusion of
Equity Values for Non-

PEO NEOs
($)		    Average Compensation
Actually Paid to Non-

PEO NEOs
($)
2024
        1,790,789        (1,032,787 )        5,443,651        6,201,653
The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables:
 
Year
   
Year-End Fair

Value of Equity
Awards Granted
During Year
That Remained
Unvested as of
Last Day of Year
for PEO
($)		      Change in Fair
Value from Last
Day of Prior
Year to Last Day
of Year of
Unvested Equity
Awards for PEO
($)		     
Vesting-Date

Fair Value of
Equity Awards
Granted During
Year that Vested
During Year for
PEO
($)		      Change in Fair
Value from Last
Day of Prior
Year to Vesting
Date of
Unvested Equity
Awards that
Vested During
Year for PEO
($)		      Fair Value at
Last Day of
Prior Year of
Equity Awards
Forfeited During
Year for PEO
($)		     
Total - Inclusion

of
Equity Values
for PEO
($)		  
2024
      11,130,588        4,675,997        —         375,987        —         16,182,572  
 
Year
   
Average Year-

End Fair Value
of Equity
Awards Granted
During Year
That Remained
Unvested as of
Last Day of Year
for
Non-PEO

NEOs
($)		      Average Change
in Fair Value
from Last Day of
Prior Year to
Last Day of Year
of Unvested
Equity Awards
for
Non-PEO

NEOs
($)		      Average
Vesting-Date

Fair Value of
Equity Awards
Granted During
Year that Vested
During Year for
Non-PEO
NEOs
($)		      Average Change
in Fair Value
from Last Day of
Prior Year to
Vesting Date of
Unvested Equity
Awards that
Vested During
Year for Non-

PEO NEOs
($)		      Average Fair
Value at Last
Day of Prior
Year of Equity
Awards
Forfeited During
Year for Non-

PEO NEOs
($)		     
Total - Average

Inclusion of
Equity Values
for
Non-PEO

NEOs
($)		  
2024
      3,750,660        1,570,299        —         122,692        —         5,443,651  
 
4.
The Peer Group total shareholder return (“TSR”) set forth in this table utilizes the peer companies used for compensation benchmarking purposes, which are summarized in our Compensation Discussion & Analysis section of the proxy statement weighted according to the respective issuer’s stock market capitalization at the beginning of the period, for the years reflected in the table above. The comparison assumes $100 was invested for the period starting December 31, 2020, through the end of the listed year in the Company and in the compensation benchmarking peers, respectively. Historical stock performance is not necessarily indicative of future stock performance.
 
2024
Alector, Inc.    Denali Therapeutics Inc.    Prime Medicine, Inc
Arcturus Therapeutics Holdings Inc.    Dyne Therapeutics, Inc.    PTC Therapeutics, Inc.
Arrowhead Pharmaceuticals Inc    Editas Medicine, Inc.    Sangamo Therapeutics, Inc.
Avidity Biosciences Inc.    Intellia Therapeutics, Inc.    Stoke Therapeutics, Inc.
Beam Therapeutics, Inc.    Ionis Pharmaceuticals, Inc.    Verve Therapeutics, Inc.
      
Named Executive Officers, Footnote
2021
  
2022
  
2023
  
2024
Michael Panzara, M.D., MPH
   Kyle Moran, CFA   Kyle Moran, CFA   Christopher Francis, Ph.D.
Chandra Vargeese, Ph.D.
   Chandra Vargeese, Ph.D.   Chandra Vargeese, Ph.D.   Kyle Moran, CFA
      Chandra Vargeese, Ph.D.
      
Peer Group Issuers, Footnote The Peer Group total shareholder return (“TSR”) set forth in this table utilizes the peer companies used for compensation benchmarking purposes, which are summarized in our Compensation Discussion & Analysis section of the proxy statement weighted according to the respective issuer’s stock market capitalization at the beginning of the period, for the years reflected in the table above. The comparison assumes $100 was invested for the period starting December 31, 2020, through the end of the listed year in the Company and in the compensation benchmarking peers, respectively. Historical stock performance is not necessarily indicative of future stock performance.      
PEO Total Compensation Amount $ 4,272,299 $ 3,874,300 $ 2,667,997 $ 3,892,610
PEO Actually Paid Compensation Amount $ 17,389,937 2,219,787 6,079,613 1,265,141
Adjustment To PEO Compensation, Footnote
Year
    Summary Compensation
Table Total for PEO
($)		    Exclusion of Stock and
Option Awards for PEO
($)		    Inclusion of Equity
Values for PEO
($)		    Compensation Actually
Paid to PEO
($)
2024
        4,272,299        (3,064,934 )        16,182,572        17,389,937
 
Year
    Average Summary
Compensation Table
Total for
Non-PEO

NEOs
($)		    Average Exclusion of
Stock and Option
Awards for Non-PEO

NEOs
($)		    Average Inclusion of
Equity Values for Non-

PEO NEOs
($)		    Average Compensation
Actually Paid to Non-

PEO NEOs
($)
2024
        1,790,789        (1,032,787 )        5,443,651        6,201,653
The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables:
 
Year
   
Year-End Fair

Value of Equity
Awards Granted
During Year
That Remained
Unvested as of
Last Day of Year
for PEO
($)		      Change in Fair
Value from Last
Day of Prior
Year to Last Day
of Year of
Unvested Equity
Awards for PEO
($)		     
Vesting-Date

Fair Value of
Equity Awards
Granted During
Year that Vested
During Year for
PEO
($)		      Change in Fair
Value from Last
Day of Prior
Year to Vesting
Date of
Unvested Equity
Awards that
Vested During
Year for PEO
($)		      Fair Value at
Last Day of
Prior Year of
Equity Awards
Forfeited During
Year for PEO
($)		     
Total - Inclusion

of
Equity Values
for PEO
($)		  
2024
      11,130,588        4,675,997        —         375,987        —         16,182,572  
 
Year
   
Average Year-

End Fair Value
of Equity
Awards Granted
During Year
That Remained
Unvested as of
Last Day of Year
for
Non-PEO

NEOs
($)		      Average Change
in Fair Value
from Last Day of
Prior Year to
Last Day of Year
of Unvested
Equity Awards
for
Non-PEO

NEOs
($)		      Average
Vesting-Date

Fair Value of
Equity Awards
Granted During
Year that Vested
During Year for
Non-PEO
NEOs
($)		      Average Change
in Fair Value
from Last Day of
Prior Year to
Vesting Date of
Unvested Equity
Awards that
Vested During
Year for Non-

PEO NEOs
($)		      Average Fair
Value at Last
Day of Prior
Year of Equity
Awards
Forfeited During
Year for Non-

PEO NEOs
($)		     
Total - Average

Inclusion of
Equity Values
for
Non-PEO

NEOs
($)		  
2024
      3,750,660        1,570,299        —         122,692        —         5,443,651  
      
Non-PEO NEO Average Total Compensation Amount $ 1,790,789 1,740,206 1,190,292 1,530,003
Non-PEO NEO Average Compensation Actually Paid Amount $ 6,201,653 1,235,658 2,247,169 519,760
Adjustment to Non-PEO NEO Compensation Footnote
Year
    Summary Compensation
Table Total for PEO
($)		    Exclusion of Stock and
Option Awards for PEO
($)		    Inclusion of Equity
Values for PEO
($)		    Compensation Actually
Paid to PEO
($)
2024
        4,272,299        (3,064,934 )        16,182,572        17,389,937
 
Year
    Average Summary
Compensation Table
Total for
Non-PEO

NEOs
($)		    Average Exclusion of
Stock and Option
Awards for Non-PEO

NEOs
($)		    Average Inclusion of
Equity Values for Non-

PEO NEOs
($)		    Average Compensation
Actually Paid to Non-

PEO NEOs
($)
2024
        1,790,789        (1,032,787 )        5,443,651        6,201,653
The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables:
 
Year
   
Year-End Fair

Value of Equity
Awards Granted
During Year
That Remained
Unvested as of
Last Day of Year
for PEO
($)		      Change in Fair
Value from Last
Day of Prior
Year to Last Day
of Year of
Unvested Equity
Awards for PEO
($)		     
Vesting-Date

Fair Value of
Equity Awards
Granted During
Year that Vested
During Year for
PEO
($)		      Change in Fair
Value from Last
Day of Prior
Year to Vesting
Date of
Unvested Equity
Awards that
Vested During
Year for PEO
($)		      Fair Value at
Last Day of
Prior Year of
Equity Awards
Forfeited During
Year for PEO
($)		     
Total - Inclusion

of
Equity Values
for PEO
($)		  
2024
      11,130,588        4,675,997        —         375,987        —         16,182,572  
 
Year
   
Average Year-

End Fair Value
of Equity
Awards Granted
During Year
That Remained
Unvested as of
Last Day of Year
for
Non-PEO

NEOs
($)		      Average Change
in Fair Value
from Last Day of
Prior Year to
Last Day of Year
of Unvested
Equity Awards
for
Non-PEO

NEOs
($)		      Average
Vesting-Date

Fair Value of
Equity Awards
Granted During
Year that Vested
During Year for
Non-PEO
NEOs
($)		      Average Change
in Fair Value
from Last Day of
Prior Year to
Vesting Date of
Unvested Equity
Awards that
Vested During
Year for Non-

PEO NEOs
($)		      Average Fair
Value at Last
Day of Prior
Year of Equity
Awards
Forfeited During
Year for Non-

PEO NEOs
($)		     
Total - Average

Inclusion of
Equity Values
for
Non-PEO

NEOs
($)		  
2024
      3,750,660        1,570,299        —         122,692        —         5,443,651  
      
Compensation Actually Paid vs. Total Shareholder Return
Relationship Between PEO and
Non-PEO
NEO C
ompensatio
n Actually Paid and TSR
The following chart sets forth the relationship between Compensation Actually Paid to our PEO, the average of Compensation Actually Paid to our
Non-PEO
NEOs, and the cumulative TSR over the four most recently completed fiscal years for the Company and the Peer Group TSR.
 
 
LOGO
     
Compensation Actually Paid vs. Net Income
Relationship Between PEO and
Non-PEO
NEO Com
pensation
Actually Paid and Net Income
The following chart sets forth the relationship between Compensation Actually Paid to our PEO, the average of Compensation Actually Paid to our
Non-PEO
NEOs, and our net income during the four most recently completed fiscal years.
 
 
LOGO
     
Total Shareholder Return Vs Peer Group
Relationship Between PEO and
Non-PEO
NEO C
ompensatio
n Actually Paid and TSR
The following chart sets forth the relationship between Compensation Actually Paid to our PEO, the average of Compensation Actually Paid to our
Non-PEO
NEOs, and the cumulative TSR over the four most recently completed fiscal years for the Company and the Peer Group TSR.
 
 
LOGO
     
Total Shareholder Return Amount $ 157.18 64.17 88.95 39.9
Peer Group Total Shareholder Return Amount 34.94 41.97 46.36 76
Net Income (Loss) $ (97,000,000) $ (57,500,000) $ (161,800,000) $ (122,200,000)
PEO Name Paul Bolno      
PEO | Equity Awards Adjustments, Excluding Value Reported in Compensation Table        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount $ 16,182,572      
PEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount 11,130,588      
PEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount 4,675,997      
PEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount 0      
PEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount 375,987      
PEO | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount 0      
PEO | Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount 16,182,572      
PEO | Stock and Option Awards [Member]        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount (3,064,934)      
Non-PEO NEO | Equity Awards Adjustments, Excluding Value Reported in Compensation Table        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount 5,443,651      
Non-PEO NEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount 3,750,660      
Non-PEO NEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount 1,570,299      
Non-PEO NEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount 0      
Non-PEO NEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount 122,692      
Non-PEO NEO | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount 0      
Non-PEO NEO | Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount 5,443,651      
Non-PEO NEO | Stock and Option Awards [Member]        
Pay vs Performance Disclosure        
Adjustment to Compensation, Amount $ (1,032,787)