Exhibit 3.3

CERTIFICATE OF AMENDMENT
TO THE AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF
GLYCOMIMETICS, INC.

GlycoMimetics, Inc., a corporation organized and existing under and by virtue of the General Corporation Law of the State of Delaware (the “Company”), hereby certifies that:

FIRST:  The name of this Company is GlycoMimetics, Inc.

SECOND:  The Company’s Amended and Restated Certificate of Incorporation was filed on January 15, 2014.

THIRD:  The Board of Directors of the Company, acting in accordance with the provisions of Sections 141 and 242 of the General Corporation Law of the State of Delaware, adopted resolutions amending the Amended and Restated Certificate of Incorporation, as currently in effect (the “Certificate of Incorporation”), to amend and restate Article I of the Certificate of Incorporation in its entirety as follows:

“The name of this corporation is Crescent Biopharma, Inc. (the “Company”).”

FOURTH: This Certificate of Amendment shall be effective at 8:50 am (Eastern Daylight Time) as of June 13, 2025.

IN WITNESS WHEREOF, the Company has caused this Certificate of Amendment to be signed by its Principal Executive Officer this  13^th  day of June, 2025.