Exhibit 107

Calculation of Filing Fee Tables

Form F-3

NuCana plc

(Exact Name of Registrant as Specified in its Charter)

Table 1: Newly Registered and Carry Forward Securities

 

		Security Type		Security Class Title		Fee Calculation  or Carry Forward Rule		Amount Registered		Proposed Maximum  Offering Price Per Unit		Maximum Aggregate Offering Price		Fee Rate		Amount of Registration  Fee		Carry Forward  Form Type		Carry Forward File Number		Carry Forward Initial Effective Date		Filing Fee Paid In Connection with Unsold Securities to be Carried Forward
Newly Registered Securities
Fees to Be Paid		Equity		Ordinary shares, nominal value £0.0004 per share (1)		—		—				—		—		—
Fees to Be Paid		Debt		Debt Securities		—		—		(3)		—		—		—
Fees to Be Paid		Equity		Warrants		—		—		(3)		—		—		—
Fees to Be Paid		Equity		Rights		—		—		(3)		—		—		—
Fees to Be Paid		Equity		Units		—		—		(3)		—		—		—
Fees to Be Paid		Unallocated (Universal) Shelf		Unallocated (Universal) Shelf		Rule 457(o)		(2)		N/A		$0.00(4)		0.00015310		$0.00(5)
Carry Forward Securities
Carry Forward Securities		Unallocated (Universal) Shelf		Unallocated (Universal) Shelf		Rule 415 (a)		(5)		(5)		$150,000,000.00		0.00010910				Form F-3		333-258941		August 27, 2021		$16,365.00
		Total Offering Amounts										$150,000,000.00				$0.00
		Total Fees Previously Paid
		Total Fee Offsets														—
		Net Fee due														$0.00

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(1) These ordinary shares are represented by American Depositary Shares (“ADSs”), each of which represents twenty-five ordinary shares of the registrant. ADSs issuable on deposit of the ordinary shares registered hereby have been registered pursuant to a separate registration statement on Form F-6 (File No.: 333-286737).

(2) There are being registered hereunder such indeterminate number of the securities of each identified class being registered as may be sold by the registrant from time to time at indeterminate prices, with the maximum aggregate offering price not to exceed $150,000,000. If any debt securities are issued at an original issue discount, then the offering price of such debt securities shall be in such greater principal amount as shall result in an aggregate offering price not to exceed $150,000,000, less the aggregate dollar amount of all securities previously issued hereunder. Any securities registered hereunder may be sold separately or as units with other securities registered hereunder. The proposed maximum initial offering price per unit will be determined, from time to time, by the registrant in connection with the issuance by the registrant of the securities registered hereunder. The securities registered also include such indeterminate number of ordinary shares represented by ADSs and the amount of debt securities as may be issued upon conversion of or exchange for debt securities that provide for conversion or exchange, upon exercise of warrants or rights or pursuant to the anti-dilution provisions of any such securities. In addition, pursuant to Rule 416 under the Securities Act of 1933, as amended (“Securities Act”), the ordinary shares represented by ADSs being registered hereunder include such indeterminate number of ordinary shares as may be issuable with respect to the ordinary shares being registered hereunder as a result of stock splits, stock dividends or similar transactions.

(3) The proposed maximum aggregate offering price per unit of class of security will be determined from time to time by the registrant in connection with the issuance by the registrant of the securities registered hereunder and is not specified as to each class of security pursuant to Instructions to the Calculation of Filing Fee Tables and Related Disclosure (2)(A)(iii)(b) of Form F-3 under the Securities Act.

(4) Estimated solely for the purpose of calculating the registration fee pursuant to Rule 457(o) under the Securities Act. In no event will the aggregate offering price of all securities sold by the registrant from time to time pursuant to this registration statement exceed $150,000,000.

(5) The registrant is carrying forward to this registration statement $150,000,000 in aggregate offering price of securities that were previously registered under the Registration Statement on Form F-3 (Commission File No. 333-258941) (the “Prior Registration Statement”) of which $16,365 was paid in connection with the registration of the primary offering of securities that remain unsold as of the date hereof (the “Carried Unsold Securities”). Pursuant to Rule 415(a)(6), the offering of the unsold securities registered under the Prior Registration Statement will be deemed terminated as of the date of effectiveness of this registration statement. To the extent that, after the filing date hereof and prior to the effectiveness of this registration statement, the registrant sells any Carried Unsold Securities pursuant to the Prior Registration Statement, the Registrant will identify in a pre-effective amendment to this registration statement the updated amount of Carried Unsold Securities from the Prior Registration Statement to be included in this registration statement pursuant to Rule 415(a)(6) and the updated amount of new securities to be registered on this registration statement.