EX-99.1

Exhibit 99.1

Burning Rock Reports First Quarter 2025 Financial Results

GUANGZHOU, China, June 6, 2025—Burning Rock Biotech Limited (NASDAQ: BNR, the “Company” or “Burning Rock”), a company focused on the application of next generation sequencing (NGS) technology in the field of precision oncology, today reported financial results for the three months ended March 31, 2025.

Recent Business Updates

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Therapy Selection and MRD

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Personalized Minimal Residual Disease (MRD) product, CanCatch^® Custom supports advancement in oesophageal squamous cell carcinoma (OSCC) treatment, with results published in the Molecular Cancer in May 2025. The study is a two-arm, multicenter, randomized, double-blind phase 2 study, comparing the efficacy of systemic treatment combining nCT with immunotherapy against nCT alone for OSCC patients. The study demonstrates that Perioperative Nivolumab plus chemotherapy is a viable and safe option for systemically treating locally advanced resectable OSCC, and monitoring minimal residual disease through ctDNA could be potentially valuable for assessing the effectiveness of adjuvant therapy and for prognostic evaluation in a systemic manner.

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Presented study results on non-small cell lung cancer and gastrointestinal stromal tumor (GIST) at the ASCO in June 2025. “Personalized tumor-informed ctDNA has the potential to inform recurrence in high-risk locally advanced stage GIST patients, especially for patients with irregular adjuvant therapy” and “MUSETALK-Lung01 (MUltiomics SEquencing Technique AppLication Kick-start) is a prospective, longitudinal, observational study designed to evaluate the clinical utility of a tumor-naïve ctDNA assay in patients with early-stage non-small cell lung cancer (NSCLC).”

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Presented multiple study results at the 2025 AACR in April, showcasing the clinical utility of the tumor-informed personalized MRD assay (CanCatch^® Custom) and the tumor-naïve methylation-based MRD assay.

First Quarter 2025 Financial Results

Revenues were RMB133.1 million (US$18.3 million) for the three months ended March 31, 2025, representing a 5.9% increase from RMB125.6 million for the same period in 2024.

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Revenue generated from central laboratory business was RMB38.3 million (US$5.3 million) for the three months ended March 31, 2025, representing a 19.6% decrease from RMB47.6 million for the same period in 2024, primarily attributable to a decrease in the number of tests, as we continued to focus on our in-hospital business.

•

Revenue generated from in-hospital business was RMB57.7 million (US$7.9 million) for the three months ended March 31, 2025, representing a 0.5% increase from RMB57.4 million for the same period in 2024, driven by a continuous growth in sales volume.

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Revenue generated from pharma research and development services was RMB37.1 million (US$5.1 million) for the three months ended March 31, 2025, representing a 79.9% increase from RMB20.6 million for the same period in 2024, primarily attributable to increased development and testing services performed for our pharma customers, and several milestones of our pharma programs were achieved.

Cost of revenues was RMB35.7 million (US$4.9 million) for the three months ended March 31, 2025, representing a 10.6% decrease from RMB39.9 million for the same period in 2024, primarily due to a decrease in cost of central laboratory business, which was in line with the decrease in revenue generated from this business.

Gross profit was RMB97.4 million (US$13.4 million) for the three months ended March 31, 2025, representing a 13.7% increase from RMB85.7 million for the same period in 2024. Gross margin was 73.2% for the three months ended March 31, 2025, compared to 68.2% for the same period in 2024. By channel, gross margin of central laboratory business was 84.1% for the three months ended March 31, 2025, compared to 77.7% during the same period in 2024, primarily due to a reduction in material and labor costs resulted from cost optimization and control measures and a decreased depreciation and rental cost in relation to our laboratory of Guangzhou headquarter; gross margin of in-hospital business was 76.1% for the three months ended March 31, 2025, compared to 68.3% during the same period in 2024, primarily due to the same reason; gross margin of pharma research and development services was 57.5% for the three months ended March 31, 2025, compared to 46.1% during the same period of 2024, primarily due to the cost optimization measures and an increase in test volume of higher margin projects.

Non-GAAP gross profit, which excludes depreciation and amortization expenses, RMB100.7 million (US$13.9 million) for the three months ended March 31, 2025, representing an 8.3% increase from RMB93.0 million for the same period in 2024. Non-GAAP gross margin was 75.6% for the three months ended March 31, 2025, compared to 74.0% for the same period in 2024.

Operating expenses were RMB112.6 million (US$15.5 million) for the three months ended March 31, 2025, representing a 46.8% decrease from RMB211.5 million for the same period in 2024. The decrease was primarily driven by budget control measures and headcount reduction to improve the Company’s operating efficiency.

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Research and development expenses were RMB40.4 million (US$5.6 million) for the three months ended March 31, 2025, representing a 38.8% decrease from RMB66.0 million for the same period in 2024, primarily due to (i) a decrease in amortized expense on share-based compensation; (ii) a decrease in the expenditure for detection research and (iii) a decrease in depreciation and amortization.

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Selling and marketing expenses were RMB40.9 million (US$5.6 million) for the three months ended March 31, 2025, representing a 12.7% decrease from RMB46.9 million for the same period in 2024, primarily due to (i) a decrease in staff cost resulted from the reorganization of our sales department to improve operating efficiency and (ii) a decrease in depreciation and amortization.

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General and administrative expenses were RMB31.3 million (US$4.3 million) for the three months ended March 31, 2025, representing a 68.3% decrease from RMB98.7 million for the same period in 2024, primarily due to (i) a decrease in amortized expense on share-based compensation; (ii) a decrease in depreciation and amortization; (iii) a decrease in staff cost resulted from the reorganization; and (iv) a decrease in operating lease expense for office building.

Net loss was RMB13.5 million (US$1.9 million) for the three months ended March 31, 2025, compared to RMB121.5 million for the same period in 2024.

Cash, cash equivalents and restricted cash were RMB497.4 million (US$68.5 million) as of March 31, 2025.

Exchange Rate Information

This press release contains translations of certain Renminbi amounts into U.S. dollars at a specified rate solely for the convenience of the reader. Unless otherwise noted, all translations from Renminbi to U.S. dollars and from U.S. dollars to Renminbi are made at a rate of RMB7.2567 to US$1.00, the exchange rate on March 31, 2025, set forth in the H.10 statistical release of the Federal Reserve Board. The Company makes no representation that the Renminbi or U.S. dollars amounts referred could be converted into U.S. dollars or Renminbi, as the case may be, at any particular rate or at all.

About Burning Rock

Burning Rock Biotech Limited (NASDAQ: BNR), whose mission is to guard life via science, focuses on the application of next generation sequencing (NGS) technology in the field of precision oncology. Its business consists of i) NGS-based therapy selection testing for late-stage cancer patients, and ii) cancer early detection, which has moved beyond proof-of-concept R&D into the clinical validation stage.

For more information about Burning Rock, please visit: ir.brbiotech.com.

Safe Harbor Statement

This press release contains forward-looking statements. These statements constitute “forward-looking” statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and as defined in the U.S. Private Securities Litigation Reform Act of 1995. These forward-looking statements can be identified by terminology such as “will,” “expects,” “anticipates,” “future,” “intends,” “plans,” “believes,” “estimates,” “target,” “confident” and similar statements. Burning Rock may also make written or oral forward-looking statements in its periodic reports to the SEC, in its annual report to shareholders, in press releases and other written materials and in oral statements made by its officers, directors or employees to third parties. Statements that are not historical facts, including statements about Burning Rock’s beliefs and expectations, are forward-looking statements. Such statements are based upon management’s current expectations and current market and operating conditions, and relate to events that involve known or unknown risks, uncertainties and other factors, all of which are difficult to predict and many of which are beyond Burning Rock’s control. Forward-looking statements involve risks, uncertainties and other factors that could cause actual results to differ materially from those contained in any such statements. All information provided in this press release is as of the date of this press release, and Burning Rock does not undertake any obligation to update any forward-looking statement as a result of new information, future events or otherwise, except as required under applicable law.

Non-GAAP Measures

In evaluating the business, the Company considers and uses non-GAAP measures, such as non-GAAP gross profit and non-GAAP gross margin, as supplemental measures to review and assess operating performance. The presentation of these non-GAAP financial measures is not intended to be considered in isolation or as a substitute for the financial information prepared and presented in accordance with accounting principles generally accepted in the United States of America (“U.S. GAAP”). The company defines non-GAAP gross profit as gross profit excluding depreciation and amortization. The company defines non-GAAP gross margin as gross margin excluding depreciation and amortization.

The company presents these non-GAAP financial measures because they are used by management to evaluate operating performance and formulate business plans. The company believe non-GAAP gross profit and non-GAAP gross margin excluding non-cash impact of depreciation and amortization reflect the company’s ongoing business operations in a manner that allows more meaningful period-to-period comparisons.

Contact: IR@brbiotech.com

Selected Operating Data


	As of
	March 31, 2024		June 30, 2024		September 30, 2024		December 31, 2024		March 31, 2025
In-hospital Channel:
Pipeline partner hospitals⁽¹⁾		28		29		30		29		30
Contracted partner hospitals⁽²⁾		59		59		61		63		63
Total number of partner hospitals		87		88		91		92		93

⁽¹⁾	Refers to hospitals that are in the process of establishing in-hospital laboratories, laboratory equipment procurement or installation, staff training or pilot testing using the Company’s products.

⁽²⁾	Refers to hospitals that have entered into contracts to purchase the Company’s products for use on a recurring basis in their respective in-hospital laboratories the Company helped them establish. Kit revenue is generated from contracted hospitals.

Selected Financial Data


	For the three months ended
Revenues	March 31, 2024		June 30, 2024		September 30, 2024		December 31, 2024		March 31, 2025
	(RMB in thousands)
Central laboratory channel		47,614		48,773		39,984		39,278		38,296
In-hospital channel		57,387		59,872		63,769		43,464		57,687
Pharma research and development channel		20,622		26,888		24,891		43,280		37,099
Total revenues		125,623		135,533		128,644		126,022		133,082


	For the three months ended
Gross profit	March 31, 2024		June 30, 2024		September 30, 2024		December 31, 2024		March 31, 2025
	(RMB in thousands)
Central laboratory channel		37,002		38,424		33,262		33,153		32,191
In-hospital channel		39,192		44,058		46,580		29,563		43,895
Pharma research and development channel		9,500		12,956		12,004		26,706		21,315
Total gross profit		85,694		95,438		91,846		89,422		97,401


	For the three months ended
Share-based compensation expenses	March 31, 2024		June 30, 2024		September 30, 2024		December 31, 2024		March 31, 2025
	(RMB in thousands)
Cost of revenues		596		464		289		520		308
Research and development expenses		12,287		12,008		3,180		3,202		1,800
Selling and marketing expenses		508		1,232		1,917		1,353		1,025
General and administrative expenses		55,990		54,407		4,732		2,937		1,413
Total share-based compensation expenses		69,381		68,111		10,118		8,012		4,546

Burning Rock Biotech Limited

Unaudited Condensed Statements of Comprehensive Loss

(in thousands, except for number of shares and per share data)


	For the three months ended
	March 31, 2024			June 30, 2024			September 30, 2024			December 31, 2024			March 31, 2025			March 31, 2025
	RMB			RMB			RMB			RMB			RMB			US$
Revenues		125,623			135,533			128,644			126,022			133,082			18,340
Cost of revenues		(39,929	)		(40,095	)		(36,798	)		(36,600	)		(35,681	)		(4,918	)

Gross profit		85,694			95,438			91,846			89,422			97,401			13,422
Operating expenses:
Research and development expenses		(65,985	)		(64,952	)		(49,150	)		(52,203	)		(40,389	)		(5,566	)
Selling and marketing expenses		(46,856	)		(48,907	)		(48,411	)		(46,730	)		(40,888	)		(5,635	)
General and administrative expenses		(98,681	)		(92,794	)		(32,874	)		(37,289	)		(31,303	)		(4,314	)
Impairment loss on long-lived assets											(35,127	)

Total operating expenses		(211,522	)		(206,653	)		(130,435	)		(171,349	)		(112,580	)		(15,515	)

Loss from operations		(125,828	)		(111,215	)		(38,589	)		(81,927	)		(15,179	)		(2,093	)
Interest income		4,038			3,187			3,173			1,814			2,581			356
Other income (expense), net		434			(82	)		1			4,353			(652	)		(90	)
Foreign exchange (loss) gain, net		(13	)		262			(129	)		(220	)		(26	)		(4	)

Loss before income tax		(121,369	)		(107,848	)		(35,544	)		(75,980	)		(13,276	)		(1,831	)
Income tax expenses		(180	)		(190	)		(201	)		(5,314	)		(224	)		(31	)

Net loss		(121,549	)		(108,038	)		(35,745	)		(81,294	)		(13,500	)		(1,862	)

Net loss attributable to Burning Rock Biotech Limited’s shareholders		(121,549	)		(108,038	)		(35,745	)		(81,294	)		(13,500	)		(1,862	)
Net loss attributable to ordinary shareholders		(121,549	)		(108,038	)		(35,745	)		(81,294	)		(13,500	)		(1,862	)
Loss per share for class A and class B ordinary shares:
Class A ordinary shares - basic and diluted		(1.19	)		(1.05	)		(0.35	)		(0.79	)		(0.13	)		(0.02	)
Class B ordinary shares - basic and diluted		(1.19	)		(1.05	)		(0.35	)		(0.79	)		(0.13	)		(0.02	)
Weighted average shares outstanding used in loss per share computation:
Class A ordinary shares - basic and diluted		85,219,188			85,271,858			85,902,670			86,036,286			90,291,658			90,291,658
Class B ordinary shares - basic and diluted		17,324,848			17,324,848			17,324,848			17,324,848			17,324,848			17,324,848
Other comprehensive income (loss), net of tax of nil:
Foreign currency translation adjustments		590			940			(4,054	)		6,009			(72	)		(10	)
Total comprehensive loss		(120,959	)		(107,098	)		(39,799	)		(75,285	)		(13,572	)		(1,872	)
Total comprehensive loss attributable to Burning Rock Biotech Limited’s shareholders		(120,959	)		(107,098	)		(39,799	)		(75,285	)		(13,572	)		(1,872	)

Burning Rock Biotech Limited

Unaudited Condensed Consolidated Balance Sheets

(In thousands)


	As of
	December 31, 2024		March 31, 2025		March 31, 2025
	RMB		RMB		US$
ASSETS
Current assets:
Cash and cash equivalents		519,849		495,145		68,233
Restricted cash		2,313		2,261		312
Accounts receivable, net		152,013		159,463		21,974
Contract assets, net		13,855		17,178		2,367
Inventories, net		62,625		65,424		9,016
Prepayments and other current assets, net		25,963		22,072		3,042

Total current assets		776,618		761,543		104,944

Non-current assets:
Property and equipment, net		47,152		41,162		5,672
Operating right-of-use assets		53,188		43,804		6,036
Intangible assets, net		421		386		53
Other non-current assets		7,926		7,822		1,078

Total non-current assets		108,687		93,174		12,839

TOTAL ASSETS		885,305		854,717		117,783

Burning Rock Biotech Limited

Unaudited Condensed Consolidated Balance Sheets (Continued)

(in thousands)


	As of
	December 31, 2024			March 31, 2025			March 31, 2025
	RMB			RMB			US$
LIABILITIES AND SHAREHOLDERS’ EQUITY
Current liabilities:
Accounts payable		33,747			35,938			4,952
Deferred revenue		117,895			117,200			16,151
Accrued liabilities and other current liabilities		89,498			76,198			10,501
Customer deposits		592			592			82
Current portion of operating lease liabilities		24,567			22,524			3,104

Total current liabilities		266,299			252,452			34,790

Non-current liabilities:
Non-current portion of operating lease liabilities		27,754			19,814			2,730
Other non-current liabilities		10,425			10,649			1,467

Total non-current liabilities		38,179			30,463			4,197

TOTAL LIABILITIES		304,478			282,915			38,987

Shareholders’ equity:
Class A ordinary shares		124			124			17
Class B ordinary shares		21			21			3
Additional paid-in capital		5,002,255			5,005,991			689,844
Treasury stock		(63,264	)		(62,453	)		(8,606	)
Accumulated deficits		(4,200,261	)		(4,213,761	)		(580,672	)
Accumulated other comprehensive loss		(158,048	)		(158,120	)		(21,790	)

Total shareholders’ equity		580,827			571,802			78,796

TOTAL LIABILITIES AND SHAREHOLDERS’ EQUITY		885,305			854,717			117,783

Burning Rock Biotech Limited

Unaudited Condensed Statements of Cash Flows

(in thousands)


	For the three months ended
	March 31, 2024			March 31, 2025			March 31, 2025
	RMB			RMB			US$
Net cash generated from (used in) operating activities		19,062			(23,527	)		(3,242	)
Net cash used in investing activities		(812	)		(1,531	)		(211	)
Net cash used in financing activities		(74	)		—			—
Effect of exchange rate on cash, cash equivalents and restricted cash		5,739			302			43
Net increase in (decrease) cash, cash equivalents and restricted cash		23,915			(24,756	)		(3,410	)
Cash, cash equivalents and restricted cash at the beginning of period		498,247			522,162			71,955
Cash, cash equivalents and restricted cash at the end of period		522,162			497,406			68,545

Burning Rock Biotech Limited

Reconciliations of GAAP and Non-GAAP Results


	For the three months ended
	March 31, 2024			June 30, 2024			September 30, 2024			December 31, 2024			March 31, 2025
				(RMB in thousands)
Gross profit:
Central laboratory channel		37,002			38,424			33,262			33,153			32,191
In-hospital channel		39,192			44,058			46,580			29,563			43,895
Pharma research and development channel		9,500			12,956			12,004			26,706			21,315
Total gross profit		85,694			95,438			91,846			89,422			97,401
Add: depreciation and amortization:
Central laboratory channel		1,919			1,226			1,277			1,010			562
In-hospital channel		1,524			824			798			623			290
Pharma research and development channel		3,856			4,417			3,846			2,534			2,412
Total depreciation and amortization included in cost of revenues		7,299			6,467			5,921			4,167			3,264
Non-GAAP gross profit:
Central laboratory channel		38,921			39,650			34,539			34,163			32,753
In-hospital channel		40,716			44,882			47,378			30,186			44,185
Pharma research and development channel		13,356			17,373			15,850			29,240			23,727
Total non-GAAP gross profit		92,993			101,905			97,767			93,589			100,665
Non-GAAP gross margin:
Central laboratory channel		81.7	%		81.3	%		86.4	%		87.0	%		85.5	%
In-hospital channel		70.9	%		75.0	%		74.3	%		69.5	%		76.6	%
Pharma research and development channel		64.8	%		64.6	%		63.7	%		67.6	%		64.0	%
Total non-GAAP gross margin		74.0	%		75.2	%		76.0	%		74.3	%		75.6	%