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Item 8.01 Other Events
Telomir Pharmaceuticals Announces Telomir-1 Resets the Body’s Epigenetic Clock, Reverses DNA Methylation, and Restores Youthful Gene Regulation in an Ultra-Rare Accelerated Aging Animal Model of Werner Syndrome
Treatment restored gene control, extended telomere length beyond healthy levels, reversed muscle and weight loss, reduced oxidative stress, and resulted in 100% survival—highlighting Telomir-1’s potential to reverse key hallmarks of aging
On June 5, 2025, Telomir Pharmaceuticals, Inc. (NASDAQ: TELO), an emerging leader in age-reversal science, announced new data from a preclinical study of its lead compound, Telomir-1, in a validated animal model of Werner Syndrome (WS), an ultra-rare genetic disorder characterized by premature aging and shortened lifespan.
The data showed that oral administration of Telomir-1 reset key biological aging markers by restoring healthy DNA methylation, a process essential for proper gene regulation. The animal model used in the study carried a mutation in the WRN gene, which in humans is responsible for DNA repair and telomere maintenance. Dysfunction of this gene leads to genomic instability, epigenetic disruption, accelerated aging, and reduced lifespan.
Telomir-1 reversed this dysfunction by restoring methylation at two CpG island regions associated with the epigenetic clock, effectively resetting the gene regulation system. The study also demonstrated:
| ● | A significant increase in telomere length, exceeding levels observed in healthy controls | |
| ● | Full reversal of muscle and body weight loss in the disease model | |
| ● | Up to 50% reduction in oxidative stress markers | |
| ● | 100% survival in all Telomir-1 treated animals, compared to 15% mortality in untreated controls |
These findings confirm and build upon Telomir Pharmaceuticals’ previously reported results in a C. elegans model with WRN mutation, which showed restoration of lifespan and normalization of age-related physiological decline following Telomir-1 treatment.
The Company believes these data support the continued development of Telomir-1 as a novel therapeutic candidate targeting the fundamental mechanisms of aging-related diseases, including those driven by telomere dysfunction and epigenetic instability.
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
| TELOMIR PHARMACEUTICALS, INC. | ||
| Dated: June 5, 2025 | By: | /s/ Erez Aminov |
| Name: | Erez Aminov | |
| Title: | Chief Executive Officer | |