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Corporate Presentation

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Developing the Next Generation of Targeted Therapies

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Higher Potency Payloads with Cancer-Specific Targeting

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Radiopharmaceutical Therapy Poised to Revolutionize Oncology Treatment Perspective’s pipeline and platform has the potential to significantly expand the breadth of tumors addressed by RPT

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Perspective’s Innovative Platform

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Perspective’s Radiopharmaceutical Platform Optimized for a Broader Therapeutic Window

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Perspective’s Proprietary Chelator Has Been Optimized for Lead-Based RPTs

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Proposed Mechanism of Action for 212Pb

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Rationale for Synergy with Immune Checkpoint Inhibitors

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Supply Chain and Manufacturing Infrastructure

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On-Demand Order Fulfillment at Regional Sites to Deliver Finished Products

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Neuroendocrine Tumors: VMT-⍺-NET

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Trial Design: [212Pb]VMT-⍺-NET Phase 1/2a For Neuroendocrine Tumors

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Anti-Tumor Activity

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Signal of Sustained Anti-Tumor Activity

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[212Pb]VMT-α-NET Was Well Tolerated

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Mild and Generally Transient Blood Creatinine Increase

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Patient (103-105) with Confirmed PR After [212Pb]VMT-α-NET

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Melanoma Program: VMT01/02

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Trial Design: [212Pb]VMT01 Phase 1/2a For Metastatic Melanoma

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Treatment Emergent Adverse Events (all grades, occurring in ≥ 2 patients)

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PSV359 is Active Against FAP-α Expression on Tumor and on Stroma

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Trial Design: [212Pb]PSV359 Phase 1/2a Trial

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General Corporate Information

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Abbreviations

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APPENDIX

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NETs Trials

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Refractory Metastatic Melanoma Trials

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Perspective’s Pre-Targeting Platform