The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103 2,572,722 353,882 SH SOLE 353,882 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 363,047 189,087 SH SOLE 189,087 0 0
AKERO THERAPEUTICS INC COM 00973Y108 3,091,822 76,379 SH SOLE 76,379 0 0
ALDEYRA THERAPEUTICS INC PUT 01438T956 190,000 100,000 SH Put SOLE 100,000 0 0
ALVOTECH ORDINARY SHARES L01800108 871,267 90,100 SH SOLE 90,100 0 0
ANAPTYSBIO INC COM 032724106 2,168,022 116,623 SH SOLE 116,623 0 0
APREA THERAPEUTICS INC COM NEW 03836J201 59,103 28,972 SH SOLE 28,972 0 0
ARVINAS INC COM 04335A105 1,370,971 195,295 SH SOLE 195,295 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 4,725,921 32,534 SH SOLE 32,534 0 0
BEIGENE LTD SPONSORED ADS 07725L102 1,769,105 6,500 SH SOLE 6,500 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 454,500 60,600 SH SOLE 60,600 0 0
BIOHAVEN LTD COM G1110E107 959,196 39,900 SH SOLE 39,900 0 0
BRIDGEBIO PHARMA INC COM 10806X102 5,721,197 165,496 SH SOLE 165,496 0 0
CENTESSA PHARMACEUTICALS PLC SPONSORED ADS 152309100 2,052,659 142,744 SH SOLE 142,744 0 0
COGENT BIOSCIENCES INC COM 19240Q201 3,723,852 621,678 SH SOLE 621,678 0 0
CORBUS PHARMACEUTICALS HLDGS COM NEW 21833P301 1,538,255 289,690 SH SOLE 289,690 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 1,720,435 51,295 SH SOLE 51,295 0 0
CYTOKINETICS INC COM NEW 23282W605 4,158,982 103,483 SH SOLE 103,483 0 0
CYTOKINETICS INC PUT 23282W955 141,450 23,000 SH Put SOLE 23,000 0 0
DISC MEDICINE INC COM 254604101 3,060,604 61,656 SH SOLE 61,656 0 0
DR REDDYS LABS LTD ADR 256135203 1,549,825 117,500 SH SOLE 117,500 0 0
DYNE THERAPEUTICS INC COM 26818M108 2,702,770 258,391 SH SOLE 258,391 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105 1,571,636 71,438 SH SOLE 71,438 0 0
ELEDON PHARMACEUTICALS INC COM 28617K101 386,952 114,145 SH SOLE 114,145 0 0
ELI LILLY & CO COM 532457108 3,859,477 4,673 SH SOLE 4,673 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108 534,546 13,100 SH SOLE 13,100 0 0
FULCRUM THERAPEUTICS INC COM 359616109 1,984,715 689,137 SH SOLE 689,137 0 0
GE HEALTHCARE TECHNOLOGIES I COMMON STOCK 36266G107 2,050,034 25,400 SH SOLE 25,400 0 0
GERON CORP COM 374163103 5,112,577 3,215,457 SH SOLE 3,215,457 0 0
GOSSAMER BIO INC COM 38341P102 1,207,799 1,097,999 SH SOLE 1,097,999 0 0
GOSSAMER BIO INC CALL 38341P902 47,500 100,000 SH Call SOLE 100,000 0 0
GUARDANT HEALTH INC COM 40131M109 5,417,953 127,182 SH SOLE 127,182 0 0
IMMUNOME INC COM 45257U108 1,775,650 263,841 SH SOLE 263,841 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 3,148,927 6,358 SH SOLE 6,358 0 0
IONIS PHARMACEUTICALS INC COM 462222100 4,091,535 135,616 SH SOLE 135,616 0 0
KARYOPHARM THERAPEUTICS INC NOTE 3.000%10/1 48576UAA4 1,522,785 2,000,000 SH SOLE 2,000,000 0 0
MBX BIOSCIENCES INC COM 55287L101 982,374 133,113 SH SOLE 133,113 0 0
NATERA INC COM 632307104 2,637,297 18,650 SH SOLE 18,650 0 0
NEKTAR THERAPEUTICS CALL 640268908 22,500 75,000 SH Call SOLE 75,000 0 0
NEKTAR THERAPEUTICS COM 640268108 1,518,068 2,232,453 SH SOLE 2,232,453 0 0
NUVATION BIO INC COM CL A 67080N101 169,507 96,311 SH SOLE 96,311 0 0
PENUMBRA INC COM 70975L107 2,406,690 9,000 SH SOLE 9,000 0 0
REGENXBIO INC COM 75901B107 2,897,759 405,281 SH SOLE 405,281 0 0
REPLIMUNE GROUP INC COM 76029N106 2,874,749 294,846 SH SOLE 294,846 0 0
RHYTHM PHARMACEUTICALS INC PUT 76243J955 70,000 40,000 SH Put SOLE 40,000 0 0
ROIVANT SCIENCES LTD PUT G76279951 15,060 75,300 SH Put SOLE 75,300 0 0
SAVARA INC COM 805111101 2,316,819 836,397 SH SOLE 836,397 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 2,711,499 84,339 SH SOLE 84,339 0 0
SOLENO THERAPEUTICS INC PUT 834203959 275 11,000 SH Put SOLE 11,000 0 0
SOLENO THERAPEUTICS INC COM 834203309 3,103,859 43,441 SH SOLE 43,441 0 0
SPRINGWORKS THERAPEUTICS INC CALL 85205L907 129,375 37,500 SH Call SOLE 37,500 0 0
STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106 1,781,961 102,944 SH SOLE 102,944 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 4,142,478 337,198 SH SOLE 337,198 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 2,114,865 118,017 SH SOLE 118,017 0 0
TRAVERE THERAPEUTICS INC CALL 89422G907 231,000 110,000 SH Call SOLE 110,000 0 0
TREVI THERAPEUTICS INC COM 89532M101 1,029,912 163,738 SH SOLE 163,738 0 0
VERU INC CALL 92536C903 900 60,000 SH Call SOLE 60,000 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104 2,929,123 217,294 SH SOLE 217,294 0 0
VYNE THERAPEUTICS INC COM 92941V308 731,225 462,801 SH SOLE 462,801 0 0