The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103 1,272,250 175,000 SH SOLE 175,000 0 0
ABIVAX SA SPONSORED ADS 00370M103 1,250,000 200,000 SH SOLE 200,000 0 0
ADAGIO MED HLDGS INC COM 00534B100 169,543 213,235 SH SOLE 213,235 0 0
AEROVATE THERAPEUTICS INC COM 008064107 2,008,000 800,000 SH SOLE 800,000 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 2,880,000 1,500,000 SH SOLE 1,500,000 0 0
ALKERMES PLC SHS G01767105 33,020,000 1,000,000 SH SOLE 1,000,000 0 0
ALLAKOS INC COM 01671P100 56,900 250,000 SH SOLE 250,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 14,851,100 55,000 SH Call SOLE 55,000 0 0
AMGEN INC COM 031162100 21,808,500 70,000 SH Call SOLE 70,000 0 0
ANTERIS TECHNOLOGIES GLOBAL COM 03675P102 1,419,600 390,000 SH SOLE 390,000 0 0
APOGEE THERAPEUTICS INC COM 03770N101 43,008,795 1,151,199 SH SOLE 1,151,199 0 0
ARCELLX INC COMMON STOCK 03940C100 34,768,000 530,000 SH SOLE 530,000 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 4,719,750 3,045,000 SH SOLE 3,045,000 0 0
AVALO THERAPEUTICS INC COM NEW 05338F306 5,263,804 657,154 SH SOLE 657,154 0 0
AXSOME THERAPEUTICS INC COM 05464T104 11,663,000 100,000 SH SOLE 100,000 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 387,500 250,000 SH SOLE 250,000 0 0
BRIDGEBIO PHARMA INC COM 10806X102 10,371,000 300,000 SH SOLE 300,000 0 0
CENTESSA PHARMACEUTICALS PLC SPONSORED ADS 152309100 22,241,000 1,546,662 SH SOLE 1,546,662 0 0
CLIMB BIO INC COM 28658R106 1,830,000 1,500,000 SH SOLE 1,500,000 0 0
COMPASS THERAPEUTICS INC COM 20454B104 248,533 130,807 SH SOLE 130,807 0 0
COMPASS THERAPEUTICS INC COM 20454B104 2,528,330 1,330,700 SH Put SOLE 1,330,700 0 0
CONTEXT THERAPEUTICS INC COM 21077P108 404,280 660,589 SH SOLE 660,589 0 0
CORCEPT THERAPEUTICS INC COM 218352102 7,995,400 70,000 SH Call SOLE 70,000 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 5,106,532 152,252 SH SOLE 152,252 0 0
CULLINAN THERAPEUTICS INC COM 230031106 1,997,095 263,817 SH SOLE 263,817 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105 4,400,000 200,000 SH Put SOLE 200,000 0 0
ERASCA INC COM 29479A108 4,577,881 3,341,519 SH SOLE 3,341,519 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108 11,425,400 280,000 SH SOLE 280,000 0 0
EXELIXIS INC COM 30161Q104 4,984,200 135,000 SH Call SOLE 135,000 0 0
GALECTIN THERAPEUTICS INC COM NEW 363225202 2,240,164 1,836,200 SH Put SOLE 1,836,200 0 0
GERON CORP COM 374163103 2,385,000 1,500,000 SH SOLE 1,500,000 0 0
IMMATICS N.V *W EXP 07/01/202 N44445117 2,958 187,204 SH SOLE 187,204 0 0
IMMUNITYBIO INC COM 45256X103 3,085,250 1,025,000 SH Put SOLE 1,025,000 0 0
IMMUNOVANT INC COM 45258J102 7,348,700 430,000 SH SOLE 430,000 0 0
INOZYME PHARMA INC COM 45790W108 3,519,616 3,867,710 SH SOLE 3,867,710 0 0
INSMED INC COM PAR $.01 457669307 10,680,600 140,000 SH SOLE 140,000 0 0
ISHARES TR RUSSELL 2000 ETF 464287655 59,847,000 300,000 SH Put SOLE 300,000 0 0
KARYOPHARM THERAPEUTICS INC NOTE 3.000%10/1 48576UAA4 11,611,232 15,250,000 PRN SOLE 15,250,000 0 0
KYMERA THERAPEUTICS INC COM 501575104 2,737,000 100,000 SH SOLE 100,000 0 0
LEXEO THERAPEUTICS INC COM 52886X107 5,138,657 1,480,881 SH SOLE 1,480,881 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 26,498,400 80,000 SH SOLE 80,000 0 0
MAZE THERAPEUTICS INC COM 578784100 2,752,500 250,000 SH SOLE 250,000 0 0
MBX BIOSCIENCES INC COM 55287L101 1,291,500 175,000 SH SOLE 175,000 0 0
MEIRAGTX HOLDINGS PLC COM G59665102 1,017,000 150,000 SH SOLE 150,000 0 0
MERUS N V COM N5749R100 13,551,381 321,962 SH SOLE 321,962 0 0
MINERALYS THERAPEUTICS INC COM 603170101 17,468,000 1,100,000 SH SOLE 1,100,000 0 0
MINERALYS THERAPEUTICS INC COM 603170101 3,176,000 200,000 SH Put SOLE 200,000 0 0
MIRUM PHARMACEUTICALS INC COM 604749101 2,238,625 49,692 SH SOLE 49,692 0 0
MONOPAR THERAPEUTICS INC COM NEW 61023L207 2,257,420 62,000 SH SOLE 62,000 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 5,530,000 50,000 SH SOLE 50,000 0 0
NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES N62509109 6,652,750 325,000 SH SOLE 325,000 0 0
NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES N62509109 2,042,906 99,800 SH Call SOLE 99,800 0 0
NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES N62509109 1,535,250 75,000 SH Put SOLE 75,000 0 0
NEWAMSTERDAM PHARMA COMPANY *W EXP 99/99/999 N62509117 2,746,212 241,957 SH SOLE 241,957 0 0
NEXTCURE INC COM 65343E108 1,105,938 2,302,598 SH SOLE 2,302,598 0 0
NKARTA INC COM 65487U108 1,472,000 800,000 SH SOLE 800,000 0 0
NURIX THERAPEUTICS INC COM 67080M103 9,630,748 810,669 SH SOLE 810,669 0 0
NUVALENT INC COM 670703107 32,623,200 460,000 SH SOLE 460,000 0 0
OAKTREE ACQUISITION CORP III UNIT 10/04/2029 G6717R120 2,595,000 250,000 SH SOLE 250,000 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106 1,222,000 325,000 SH SOLE 325,000 0 0
OMEROS CORP COM 682143102 81,855 9,958 SH SOLE 9,958 0 0
OMEROS CORP NOTE 5.250% 2/1 682143AG7 14,275,238 15,525,000 PRN SOLE 15,525,000 0 0
ONKURE THERAPEUTICS INC COM CL A 68277Q105 1,694,884 394,159 SH SOLE 394,159 0 0
ORUKA THERAPEUTICS INC COM 687604108 5,595,414 545,362 SH SOLE 545,362 0 0
OVID THERAPEUTICS INC COM 690469101 208,198 667,516 SH SOLE 667,516 0 0
PERCEPTIVE CAP SOLUTIONS COR CL A ORD SHS G70077105 3,619,000 350,000 SH SOLE 350,000 0 0
PERSPECTIVE THERAPEUTICS INC COM NEW 46489V302 4,737,537 2,224,196 SH SOLE 2,224,196 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 4,368,401 3,284,512 SH SOLE 3,284,512 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 19,344,000 400,000 SH SOLE 400,000 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 8,342,100 172,500 SH Call SOLE 172,500 0 0
Q32 BIO INC COM 746964105 45,832 27,777 SH SOLE 27,777 0 0
RADIOPHARM THERANOSTICS LTD SPONSORED ADS 75041J101 310,726 64,600 SH SOLE 64,600 0 0
REPARE THERAPEUTICS INC COM 760273102 197,180 200,000 SH SOLE 200,000 0 0
REZOLUTE INC COM NEW 76200L309 4,930,000 1,700,000 SH SOLE 1,700,000 0 0
ROCKET PHARMACEUTICALS INC *W EXP 09/02/202 77313F114 3,525 75,000 SH SOLE 75,000 0 0
ROIVANT SCIENCES LTD SHS G76279101 1,513,500 150,000 SH SOLE 150,000 0 0
SOLENO THERAPEUTICS INC COM 834203309 3,572,500 50,000 SH SOLE 50,000 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 16,781,700 30,000 SH SOLE 30,000 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 223,756,000 400,000 SH Put SOLE 400,000 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 40,550,000 500,000 SH Put SOLE 500,000 0 0
SPYRE THERAPEUTICS INC COM NEW 00773J202 7,771,875 481,678 SH SOLE 481,678 0 0
SUTRO BIOPHARMA INC COM 869367102 489,721 752,722 SH SOLE 752,722 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 21,518,000 1,400,000 SH SOLE 1,400,000 0 0
THIRD HARMONIC BIO INC COM 88427A107 1,283,900 370,000 SH SOLE 370,000 0 0
TOURMALINE BIO INC COM 89157D105 1,521,000 100,000 SH Call SOLE 100,000 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 19,174,400 1,070,000 SH SOLE 1,070,000 0 0
TRAVERE THERAPEUTICS INC NOTE 2.250% 3/0 89422GAA5 6,993,000 7,000,000 PRN SOLE 7,000,000 0 0
TREVI THERAPEUTICS INC COM 89532M101 7,862,500 1,250,000 SH SOLE 1,250,000 0 0
UNIQURE NV SHS N90064101 4,240,000 400,000 SH SOLE 400,000 0 0
VAXCYTE INC COM 92243G108 944,000 25,000 SH SOLE 25,000 0 0
VERA THERAPEUTICS INC CL A 92337R101 8,530,535 355,143 SH SOLE 355,143 0 0
VERA THERAPEUTICS INC CL A 92337R101 6,365,300 265,000 SH Call SOLE 265,000 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 39,046,350 615,000 SH SOLE 615,000 0 0
VIKING THERAPEUTICS INC COM 92686J106 603,750 25,000 SH SOLE 25,000 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104 5,257,200 390,000 SH SOLE 390,000 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 14,746,000 1,825,000 SH SOLE 1,825,000 0 0
XENON PHARMACEUTICALS INC COM 98420N105 44,560,271 1,328,175 SH SOLE 1,328,175 0 0
ZURA BIO LTD CLASS A ORD SHS G9TY5A101 288,102 223,335 SH SOLE 223,335 0 0