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Note 5 - Significant Agreements and Contracts (Details Textual) $ in Millions	1 Months Ended		3 Months Ended		12 Months Ended
	Mar. 31, 2025 USD ($)	Aug. 31, 2014 USD ($)	Mar. 31, 2025 USD ($)	Mar. 31, 2024 USD ($)	Dec. 31, 2025 USD ($)	Dec. 31, 2024 USD ($)	Dec. 31, 2023 USD ($)	Aug. 31, 2024 USD ($)	Jan. 01, 2024 USN ($)	Jan. 31, 2023 USD ($)
Research and Development Expense			$ 4,837,798	$ 2,814,258
Revenues			1,917,491	2,347,250
Vertex Option and License Agreement [Member]
Research and Development Expense		$ 100,000
Contractual Obligation		$ 117,000,000
Agreement, Milestone, Period for Net Sales		12 months
Agreement, Maximum Deduction Percentage of Fees and Payments		50.00%
Payments for License Agreement		$ 100,000	0	0
National Institute of Aging Grant [Member]
Government Assistance, Asset								$ 300,000	$ 21.3	$ 21,000,000
Government Assistance, Income, Increase (Decrease)	$ 5,600,000					$ 8,400,000	$ 6,700,000
Revenues			1,900,000	$ 2,300,000
Proceeds From Grants			17,200,000
Grant Funding Remaining	4,000,000		4,000,000
Deferred Revenue, Current	$ 1,600,000		$ 1,600,000			$ 2,300,000
Grant Amount, Received, Percentage	90.00%
Grant Amount Remaining, Percentage	10.00%
National Institute of Aging Grant [Member] \| Forecast [Member]
Government Assistance, Income, Increase (Decrease)					$ 6,200,000