Share-Based Compensation (Details) - USD ($) $ in Thousands |
3 Months Ended | |
|---|---|---|
Mar. 31, 2025 |
Mar. 31, 2024 |
|
| Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] | ||
| Total share-based compensation expense, pre-tax | $ 67,653 | $ 61,441 |
| Income tax benefit from share-based compensation expense | (9,534) | (3,399) |
| Total share-based compensation expense, net of tax | 58,119 | 58,042 |
| Selling, general and administrative | ||
| Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] | ||
| Total share-based compensation expense, pre-tax | 41,674 | 40,213 |
| Research and development | ||
| Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] | ||
| Total share-based compensation expense, pre-tax | 20,930 | 18,831 |
| Cost of product sales | ||
| Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] | ||
| Total share-based compensation expense, pre-tax | $ 5,049 | $ 2,397 |