Certain Balance Sheet Items (Tables)

3 Months Ended

Mar. 31, 2025

Property, plant and equipment consisted of the following (in thousands):


	March 31, 2025		December 31, 2024
Manufacturing equipment and machinery	$	90,767	$	87,451
Land and buildings	72,502		71,902
Leasehold improvements	70,489		70,201
Computer software	44,914		42,635
Construction-in-progress	43,078		34,493
Computer equipment	20,113		20,137
Furniture and fixtures	8,570		8,551

Subtotal	350,433		335,370
Less accumulated depreciation and amortization	(171,564)		(161,957)
Property, plant and equipment, net	$	178,869	$	173,413

Accrued liabilities consisted of the following (in thousands):


	March 31, 2025		December 31, 2024
Rebates and other sales deductions	$	442,765	$	342,717
Accrued litigation settlement expenses	172,000		—
Employee compensation and benefits	139,388		153,133
Clinical trial accruals	32,700		49,962
Consulting and professional services	32,279		26,221
Accrued royalties	29,270		36,802
Sales return reserve	28,132		26,428
Inventory-related accruals	27,396		25,509
Accrued development expenses	26,295		23,099
Selling and marketing accruals	22,532		26,981
Accrued interest	21,485		41,626

Current portion of lease liabilities	13,444		14,779
Accrued construction-in-progress	9,377		10,061
Accrued collaboration expenses	6,485		18,005

Accrued milestones	—		27,500
Derivative instrument liabilities	—		10,198
Other	60,370		77,926
Total accrued liabilities	$	1,063,918	$	910,947