| Certain Balance Sheet Items |
Certain Balance Sheet Items Property, plant and equipment consisted of the following (in thousands): | | | | | | | | | | | | | March 31,
2025 | | December 31,
2024 | | Manufacturing equipment and machinery | $ | 90,767 | | | $ | 87,451 | | | Land and buildings | 72,502 | | | 71,902 | | | Leasehold improvements | 70,489 | | | 70,201 | | | Computer software | 44,914 | | | 42,635 | | | Construction-in-progress | 43,078 | | | 34,493 | | | Computer equipment | 20,113 | | | 20,137 | | | Furniture and fixtures | 8,570 | | | 8,551 | | | | | | | Subtotal | 350,433 | | | 335,370 | | | Less accumulated depreciation and amortization | (171,564) | | | (161,957) | | | Property, plant and equipment, net | $ | 178,869 | | | $ | 173,413 | |
Accrued liabilities consisted of the following (in thousands): | | | | | | | | | | | | | March 31,
2025 | | December 31,
2024 | | Rebates and other sales deductions | $ | 442,765 | | | $ | 342,717 | | | Accrued litigation settlement expenses | 172,000 | | | — | | | Employee compensation and benefits | 139,388 | | | 153,133 | | | Clinical trial accruals | 32,700 | | | 49,962 | | | Consulting and professional services | 32,279 | | | 26,221 | | | Accrued royalties | 29,270 | | | 36,802 | | | Sales return reserve | 28,132 | | | 26,428 | | | Inventory-related accruals | 27,396 | | | 25,509 | | | Accrued development expenses | 26,295 | | | 23,099 | | | Selling and marketing accruals | 22,532 | | | 26,981 | | | Accrued interest | 21,485 | | | 41,626 | | | | | | | Current portion of lease liabilities | 13,444 | | | 14,779 | | | Accrued construction-in-progress | 9,377 | | | 10,061 | | | Accrued collaboration expenses | 6,485 | | | 18,005 | | | | | | | Accrued milestones | — | | | 27,500 | | | Derivative instrument liabilities | — | | | 10,198 | | | Other | 60,370 | | | 77,926 | | | Total accrued liabilities | $ | 1,063,918 | | | $ | 910,947 | |
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