v3.25.1
COMMITMENTS, CONTINGENCIES AND DEBT (Details Narrative) - USD ($)
 1 Months Ended 5 Months Ended 12 Months Ended 29 Months Ended
Dec. 16, 2024
Jun. 26, 2023
Mar. 20, 2023
Dec. 03, 2020
Apr. 15, 2016
Mar. 22, 2016
Aug. 31, 2022
Dec. 31, 2022
Dec. 31, 2025
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2024
Jan. 31, 2023
Product Liability Contingency [Line Items]                          
Forgiveness of DECD loan                   $ 1,000,000    
other income                   2,000,000      
Insurance reimbursment received                     250,000    
Royalty expense                   293,000 324,000    
Research and development expense                   $ 3,266,000 $ 4,035,000    
Research Collaboration Agreement With Johns Hopkins University School Of Medicine [Member]                          
Product Liability Contingency [Line Items]                          
Percentage of royalty paid                   4.00%      
Annual minimum royalties                   $ 57,500      
Sponsored Research Agreement [Member]                          
Product Liability Contingency [Line Items]                          
Sponsored research agreement, amount             $ 1,252,000            
Sponsored research agreement, paid percentage               68.00%     15.00%    
Research and development expense                     $ 215,000 $ 1,083,000  
Payments of research agreements                   1,040,000      
Additional payments                   212,000      
License Agreement With Multiple Entities [Member]                          
Product Liability Contingency [Line Items]                          
Initial license fee     $ 75,000                    
Annual license fee     $ 50,000                    
License Agreement With Multiple Entities [Member] | Maximum [Member]                          
Product Liability Contingency [Line Items]                          
Royalty expense                   1,350,000      
New Sub Lease Agreement [Member]                          
Product Liability Contingency [Line Items]                          
Security deposit                         $ 10,000,000
Severance Agreements [Member] | Chief Executive Officer [Member]                          
Product Liability Contingency [Line Items]                          
Severance expense $ 393,000                        
Accrual for severance expense relates to salary 375,000                        
Accrual for severance expense relates to benefits $ 18,000                        
Accrued for severance                   356,000      
Accrued for health and dental insurance                   $ 18,000      
Austin Texas Facility [Member]                          
Product Liability Contingency [Line Items]                          
Operating lease, renewal term                   54 months   54 months  
Lease expires date                   Aug. 31, 2031      
Lease extended description                   option to extend the lease for an additional three years      
Short term lease expenses                   $ 58,000 114,000    
Variable rent expense                   58,000 114,000    
Amended Loan Agreement [Member]                          
Product Liability Contingency [Line Items]                          
Unamortized debt issuance costs                   4,000,000   $ 4,000,000  
Long-term debt, gross                   $ 614,000   $ 614,000  
Forecast [Member] | Sponsored Research Agreement [Member]                          
Product Liability Contingency [Line Items]                          
Sponsored research agreement, paid percentage                 17.00%        
DECD Loan [Member]                          
Product Liability Contingency [Line Items]                          
Line of credit, maximum borrowing capacity           $ 4,000,000              
Debt instrument fixed interest rate           2.00%              
Maturity date           Apr. 15, 2026              
Proceeds from loan       $ 2,000,000 $ 2,000,000                
Maximum loan forgiveness amount under loan agreement           $ 1,500,000              
Forgiveness of DECD loan   $ 1,000,000                      
other income                     $ 1,000,000    
Percentage of penalty included in loan agreement           5.00%              
DECD Loan [Member] | Loan Agreement Target Employment Milestone [Member]                          
Product Liability Contingency [Line Items]                          
Proceeds from loan       $ 1,000,000                  
Insurance Notes [Member]                          
Product Liability Contingency [Line Items]                          
Debt instrument fixed interest rate                   7.52% 7.79% 7.52%  
Maturity date                   Aug. 01, 2025      
Aggregate principal outstanding amount                   $ 614,000 $ 670,000 $ 614,000