v3.25.1
CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2025
Mar. 31, 2024
Cash flows from operating activities:    
Net loss $ (57,479) $ (65,935)
Non-cash adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 14,405 13,517
Non-cash interest expense on liability related to the sale of future royalties 34,962 31,565
Stock-based compensation 56,712 45,347
Unrealized loss (gain) on marketable equity securities 956 (78)
Change in fair value of development derivative liability 58,891 8,586
Deferred income taxes 9,639 454
Other (19,354) (6,513)
Changes in operating assets and liabilities:    
Accounts receivable, net (7,434) 410
Inventory 6,215 22
Prepaid expenses and other assets (32,769) (75,462)
Accounts payable, accrued expenses and other liabilities (155,737) (4,865)
Deferred revenue (27,321) (28,563)
Net cash used in operating activities (118,314) (81,515)
Cash flows from investing activities:    
Purchases of property, plant and equipment (8,970) (12,973)
Purchases of marketable securities (401,642) (420,115)
Sales and maturities of marketable securities 524,381 365,468
Proceeds from maturity of restricted investments 48,825 39,975
Purchases of restricted investments (48,825) (39,975)
Net cash provided by (used in) investing activities 113,769 (67,620)
Cash flows from financing activities:    
Proceeds from exercise of stock options and other types of equity, net 49,365 25,859
(Repayment of) proceeds from development derivative, net (5,281) 3,052
Net cash provided by financing activities 44,084 28,911
Effect of exchange rate changes on cash, cash equivalents and restricted cash 14,058 (9,941)
Net increase (decrease) in cash, cash equivalents and restricted cash 53,597 (130,165)
Cash, cash equivalents and restricted cash, beginning of period 968,652 814,884
Cash, cash equivalents and restricted cash, end of period 1,022,249 684,719
Supplemental disclosure of cash flows:    
Cash paid for interest 66,933 30,945
Cash paid for taxes 2,969 1,987
Operating lease right-of-use assets obtained in exchange for new operating lease liabilities 9,826 774
Supplemental disclosure of noncash investing activities:    
Capital expenditures included in accounts payable and accrued expenses $ 3,650 $ 2,242