v3.25.1
CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended
Mar. 31, 2025
Mar. 31, 2024
Revenues:    
Total revenues $ 594,189 $ 494,333
Operating costs and expenses:    
Cost of goods sold 70,183 54,613
Cost of collaborations and royalties 858 11,363
Research and development 265,122 260,995
Selling, general and administrative 239,949 210,797
Total operating costs and expenses 576,112 537,768
Income (loss) from operations 18,077 (43,435)
Other (expense) income:    
Interest expense (38,646) (35,253)
Interest income 28,673 29,645
Other expense, net (49,700) (14,544)
Total other expense, net (59,673) (20,152)
Loss before income taxes (41,596) (63,587)
Provision for income taxes (15,883) (2,348)
Net loss $ (57,479) $ (65,935)
Net loss per common share - basic (in dollars per share) $ (0.44) $ (0.52)
Net loss per common share - diluted (in dollars per share) $ (0.44) $ (0.52)
Weighted-average common shares used to compute - basic (in shares) 129,676 126,138
Weighted-average common shares used to compute - diluted (in shares) 129,676 126,138
Statements of Comprehensive Loss    
Net loss $ (57,479) $ (65,935)
Other comprehensive loss:    
Unrealized gain (loss) on marketable securities 1,030 (3,568)
Foreign currency translation loss (4,084) (78)
Defined benefit pension plans, net of tax 55 33
Total other comprehensive loss (2,999) (3,613)
Comprehensive loss (60,478) (69,548)
Net product revenues    
Revenues:    
Total revenues 468,538 365,163
Net revenues from collaborations    
Revenues:    
Total revenues 99,185 118,548
Royalty revenue    
Revenues:    
Total revenues $ 26,466 $ 10,622