Pay vs Performance Disclosure - USD ($)

12 Months Ended

Dec. 31, 2024

Dec. 31, 2023

Dec. 31, 2022

As required by Section 953(a) of the Dodd-Frank Wall Street Reform and Consumer Protection Act, and Item 402(v) of Regulation S-K, we are providing the following information about the relationship between executive “compensation actually paid” and certain financial performance of our Company.


					Average				Value of Initial
					Summary		Average		Fixed $100
	Summary				Compensation		Compensation		Investment Based
	Compensation		Compensation		Table Total for		Actually Paid to		On Total
	Table Total for		Actually paid to		Non-CEO NEOs		Non-CEO NEOs		Stockholder
Year	Mr. Bashan (1)		Mr. Bashan (2)		(3)		(4)		Return (5)		Net Income (6)
2024	$	1,527,792	$	524,655	$	749,713	$	488,529	$	105.62	$	2,932,000
2023	$	2,684,941	$	3,186,324	$	902,702	$	1,094,613		129.93	$	8,312,000
2022	$	1,468,296	$	1,899,221	$	795,773	$	1,056,338		37.74	$	(14,927,000)

(1)The dollar amounts reported are the amounts reported in the “Total” column of the Summary Compensation Table for Mr. Bashan, our President and Chief Executive Officer.

(2)The dollar amounts reported represent the amount of “compensation actually paid” to Mr. Bashan, as computed in accordance with SEC regulations. The dollar amounts do not reflect the actual amount of compensation earned by or paid to Mr. Bashan during the applicable year. In accordance with SEC regulations, the following adjustments were made to Mr. Bashan’s total compensation to determine the compensation actually paid:


			Less: Summary
	Summary		Compensation				Equals:
	Compensation		Table Reported				Compensation
	Table Total for		Value of Equity		Plus: Equity Award		Actually paid to
Year	Mr. Bashan		Awards (a)		Adjustments (b)		Mr. Bashan
2024	$	1,527,792	$	1,037,121	$	33,984	$	524,655
2023	$	2,684,941	$	1,308,118	$	1,809,501	$	3,186,324
2022	$	1,468,296	$	995,140	$	1,426,065	$	1,899,221

(a)Represents the aggregate grant-date fair value of equity awards as reported in the “Stock Awards” and “Option Awards” columns in the Summary Compensation Table for the applicable year.

(b)The equity award adjustments for each applicable year were as set forth in the table below. The valuation assumptions used to calculate fair values did not materially differ from those disclosed at the time of grant. The amounts deducted or added in calculating the equity award adjustments are as follows:


									Fair Value
									at the End		Value of
									of the Prior		Dividend
			Year over Year		Year End				Year of		Equivalents
			Change in fair		Fair Value		Year over Year		Equity		Accrued or
			Value of		of Vested		Change in Fair		Awards that		other Earnings
	Year End Fair		Outstanding		Equity		Value of Equity		Failed to		Paid on Stock
	Value of Unvested		and Unvested		Awards		Awards Granted		meet		Awards not
	Equity Awards		Equity Awards		Granted in		in Prior Years		Vesting		Otherwise		Total Equity
	Granted in the		Granted in		the Covered		that Vested in the		Conditions		Reflected in		Award
Year	Covered Year		prior Years		Year		Year		in the Year		Fair Value		Adjustments
2024	$	—	$	5,049	$	329,950	$	(301,015)	$	—	$	—	$	33,984
2023	$	934,501	$	210,735	$	505,750	$	158,515	$	—	$	—	$	1,809,501
2022	$	717,652	$	110,664	$	566,768	$	30,981	$	—	$	—	$	1,426,065

(3)The dollar amounts reported represent the average of the amounts reported for our Named Executive Officers as a group (excluding our CEO) in the “Total” column of the Summary Compensation Table in each applicable year. The Named Executive Officers included for purposes of calculating the average amounts are Mr. Rubin and Mr. Naos.

(4)The dollar amounts reported represent the average amount of “compensation actually paid” to the Named Executive Officers identified in footnote 3, as computed in accordance with SEC regulations. The dollar amounts do not reflect the actual amount of compensation earned by or paid to the Named Executive Officers during the applicable year. In accordance with the SEC regulations, the following adjustments were made to average total compensation for the Named Executive Officers for each year to determine the compensation actually paid:


	Average Reported
	Summary		Less: Summary				Equals: Average
	Compensation		Compensation Table Average		Plus: Average		Compensation
	Table Total for		Reported Value of		Equity Award		Actually Paid to
Year	Other NEOs		Equity Awards		Adjustments (a)			Other NEOs
2024	$	749,713	$	293,799	$	32,616	$	488,529
2023	$	902,702	$	302,403	$	494,314	$	1,094,613
2022	$	795,773	$	183,933	$	444,498	$	1,056,338

(a)	The amounts deducted or added in calculating the total average equity award adjustments are as follows:


							Year over		Fair Value at		Average Value
					Average Year		Year Average		the End of		of Dividend
			Year over Year		End Fair		Change in		the Prior		Equivalents
			Average		Value of		Fair Value of		Year of		Accrued or
	Average Year End		Change in fair		Vested		Equity		Equity		other Earnings
	Fair Value of		Value of		Equity		Awards		Awards that		Paid on Stock
	Unvested Equity		Outstanding and		Awards		Granted in		Failed to		Awards not
	Awards Granted		Unvested Equity Awards		Granted in		Prior Years		meet Vesting		Otherwise		Total Average
	in the Covered		Granted in prior		the Covered		that Vested in		Conditions in		Reflected in		Equity Award
Year	Year		Years		Year		the Year		the Year		Fair Value		Adjustments
2024	$	66,865	$	3,326	$	55,513	$	(93,089)	$	—	$	—	$	32,616
2023	$	317,561	$	89,197	$	22,868	$	64,688	$	—	$	—	$	494,314
2022	$	330,120	$	36,648	$	67,913	$	9,817	$	—	$	—	$	444,498

(5)Cumulative TSR is the value of a $100 investment in our common stock calculated by dividing the difference between the per share price of our common stock at the end of each year shown and the beginning of the measurement period by the per share price of our common stock at the beginning of the measurement period.

(6)The dollar amounts reported represent the amount of net income reflected in our Consolidated Statements of Income included in our Annual Report on Form 10-K for the applicable fiscal year.

Named Executive Officers, Footnote

(1)The dollar amounts reported are the amounts reported in the “Total” column of the Summary Compensation Table for Mr. Bashan, our President and Chief Executive Officer.

PEO Total Compensation Amount

$ 1,527,792

$ 2,684,941

$ 1,468,296

PEO Actually Paid Compensation Amount

$ 524,655

3,186,324

1,899,221

Adjustment To PEO Compensation, Footnote


			Less: Summary
	Summary		Compensation				Equals:
	Compensation		Table Reported				Compensation
	Table Total for		Value of Equity		Plus: Equity Award		Actually paid to
Year	Mr. Bashan		Awards (a)		Adjustments (b)		Mr. Bashan
2024	$	1,527,792	$	1,037,121	$	33,984	$	524,655
2023	$	2,684,941	$	1,308,118	$	1,809,501	$	3,186,324
2022	$	1,468,296	$	995,140	$	1,426,065	$	1,899,221

(a)Represents the aggregate grant-date fair value of equity awards as reported in the “Stock Awards” and “Option Awards” columns in the Summary Compensation Table for the applicable year.


									Fair Value
									at the End		Value of
									of the Prior		Dividend
			Year over Year		Year End				Year of		Equivalents
			Change in fair		Fair Value		Year over Year		Equity		Accrued or
			Value of		of Vested		Change in Fair		Awards that		other Earnings
	Year End Fair		Outstanding		Equity		Value of Equity		Failed to		Paid on Stock
	Value of Unvested		and Unvested		Awards		Awards Granted		meet		Awards not
	Equity Awards		Equity Awards		Granted in		in Prior Years		Vesting		Otherwise		Total Equity
	Granted in the		Granted in		the Covered		that Vested in the		Conditions		Reflected in		Award
Year	Covered Year		prior Years		Year		Year		in the Year		Fair Value		Adjustments
2024	$	—	$	5,049	$	329,950	$	(301,015)	$	—	$	—	$	33,984
2023	$	934,501	$	210,735	$	505,750	$	158,515	$	—	$	—	$	1,809,501
2022	$	717,652	$	110,664	$	566,768	$	30,981	$	—	$	—	$	1,426,065

Non-PEO NEO Average Total Compensation Amount

$ 749,713

902,702

795,773

Non-PEO NEO Average Compensation Actually Paid Amount

$ 488,529

1,094,613

1,056,338

Adjustment to Non-PEO NEO Compensation Footnote


	Average Reported
	Summary		Less: Summary				Equals: Average
	Compensation		Compensation Table Average		Plus: Average		Compensation
	Table Total for		Reported Value of		Equity Award		Actually Paid to
Year	Other NEOs		Equity Awards		Adjustments (a)			Other NEOs
2024	$	749,713	$	293,799	$	32,616	$	488,529
2023	$	902,702	$	302,403	$	494,314	$	1,094,613
2022	$	795,773	$	183,933	$	444,498	$	1,056,338

(a)	The amounts deducted or added in calculating the total average equity award adjustments are as follows:


							Year over		Fair Value at		Average Value
					Average Year		Year Average		the End of		of Dividend
			Year over Year		End Fair		Change in		the Prior		Equivalents
			Average		Value of		Fair Value of		Year of		Accrued or
	Average Year End		Change in fair		Vested		Equity		Equity		other Earnings
	Fair Value of		Value of		Equity		Awards		Awards that		Paid on Stock
	Unvested Equity		Outstanding and		Awards		Granted in		Failed to		Awards not
	Awards Granted		Unvested Equity Awards		Granted in		Prior Years		meet Vesting		Otherwise		Total Average
	in the Covered		Granted in prior		the Covered		that Vested in		Conditions in		Reflected in		Equity Award
Year	Year		Years		Year		the Year		the Year		Fair Value		Adjustments
2024	$	66,865	$	3,326	$	55,513	$	(93,089)	$	—	$	—	$	32,616
2023	$	317,561	$	89,197	$	22,868	$	64,688	$	—	$	—	$	494,314
2022	$	330,120	$	36,648	$	67,913	$	9,817	$	—	$	—	$	444,498

Compensation Actually Paid vs. Total Shareholder Return

Compensation actually paid to Mr. Bashan during the year ended December 31, 2024 was approximately $0.5 million, a decrease of approximately $2.7 million from approximately $3.2 million for the year ended December 31, 2023. Average compensation actually paid to our Non-CEO Named Executive Officers for the years ended December 31, 2024 was approximately $0.5 million, a decrease of approximately $0.6 million from approximately $1.1 million for the year ended December 31, 2023. For the year ended December 31, 2024, our TSR was $105.62, a decrease of 18.7%, compared to TSR of $129.93 for the year ended December 31, 2023. Our net income for the year ended December 31, 2024 was $2.9 million compared to net income of $8.3 million over the same period in 2023.

Compensation actually paid to Mr. Bashan and to our Non-CEO Named Executive Officers as a group is not directly correlated with our TSR or our net income (loss) over the three years presented in the above tables. Over the course of fiscal year 2022 and the first half of fiscal year 2023, we focused primarily on the clinical and regulatory development and approval of pegunigalsidase alfa. During the second half of fiscal year 2023 through fiscal year 2024, we shifted our focus to the support of our commercial partner’s launch efforts post approval, and redirecting our R&D and clinical resources towards the strengthening of our pipeline of product candidates, including but not limited to, our leading drug candidate, PRX-115 (pegylated Uricase for the potential treatment of uncontrolled Gout). Accordingly, TSR and net income (loss), as performance measures, are not directly correlated to our executive compensation determinations. As increases in the market price of our common stock correspond to increases in the fair market value of our equity grants, the calculation of compensation actually paid with respect to equity grants held by Mr. Bashan and to

our Non-CEO Named Executive Officers increases in a like manner. In the year ended December 31, 2023, given the approval of pegunigalsidase alfa for adult patients with Fabry disease by both the FDA and the EMA, the advancement in the clinical development of our PRX-115 drug candidate and strengthening of our Company’s liquidity and cash position, the Compensation Committee of our Board of Directors elected to award to Mr. Bashan and to our Non-CEO Named Executive Officers, as well as other officers and employees of our Company, an annual cash bonus and a one-time special cash bonus for such positive achievements.

Compensation Actually Paid vs. Net Income

Total Shareholder Return Amount

$ 105.62

129.93

37.74

Net Income (Loss)

$ 2,932,000

8,312,000

(14,927,000)

PEO Name

Mr. Bashan

Equity Awards Adjustments, Footnote


									Fair Value
									at the End		Value of
									of the Prior		Dividend
			Year over Year		Year End				Year of		Equivalents
			Change in fair		Fair Value		Year over Year		Equity		Accrued or
			Value of		of Vested		Change in Fair		Awards that		other Earnings
	Year End Fair		Outstanding		Equity		Value of Equity		Failed to		Paid on Stock
	Value of Unvested		and Unvested		Awards		Awards Granted		meet		Awards not
	Equity Awards		Equity Awards		Granted in		in Prior Years		Vesting		Otherwise		Total Equity
	Granted in the		Granted in		the Covered		that Vested in the		Conditions		Reflected in		Award
Year	Covered Year		prior Years		Year		Year		in the Year		Fair Value		Adjustments
2024	$	—	$	5,049	$	329,950	$	(301,015)	$	—	$	—	$	33,984
2023	$	934,501	$	210,735	$	505,750	$	158,515	$	—	$	—	$	1,809,501
2022	$	717,652	$	110,664	$	566,768	$	30,981	$	—	$	—	$	1,426,065

(a)	The amounts deducted or added in calculating the total average equity award adjustments are as follows:


							Year over		Fair Value at		Average Value
					Average Year		Year Average		the End of		of Dividend
			Year over Year		End Fair		Change in		the Prior		Equivalents
			Average		Value of		Fair Value of		Year of		Accrued or
	Average Year End		Change in fair		Vested		Equity		Equity		other Earnings
	Fair Value of		Value of		Equity		Awards		Awards that		Paid on Stock
	Unvested Equity		Outstanding and		Awards		Granted in		Failed to		Awards not
	Awards Granted		Unvested Equity Awards		Granted in		Prior Years		meet Vesting		Otherwise		Total Average
	in the Covered		Granted in prior		the Covered		that Vested in		Conditions in		Reflected in		Equity Award
Year	Year		Years		Year		the Year		the Year		Fair Value		Adjustments
2024	$	66,865	$	3,326	$	55,513	$	(93,089)	$	—	$	—	$	32,616
2023	$	317,561	$	89,197	$	22,868	$	64,688	$	—	$	—	$	494,314
2022	$	330,120	$	36,648	$	67,913	$	9,817	$	—	$	—	$	444,498