Professionally Managed Portfolios

c/o U.S. Bank Global Fund Services

777 East Wisconsin Avenue

Milwaukee, WI 53202

May 2, 2024

VIA EDGAR TRANSMISSION

Division of Investment Management

U.S. Securities and Exchange Commission

100 F Street, N.E.

Washington, D.C. 20549

Re:

Professionally Managed Portfolios (the “Trust”)

File Nos.: 33-12213 and 811-05037

Muzinich Credit Opportunities Fund (S000036430)

Muzinich Flexible U.S. High Yield Income Fund (S000036429)

Muzinich Low Duration Fund (S000054438)

Dear Sir or Madam:

Pursuant to Rule 497(j) under the Securities Act of 1933, as amended, the Investment Company Act of 1940, as amended, and the regulations thereunder, the Trust on behalf of its series, Muzinich Credit Opportunities Fund, Muzinich Flexible U.S. High Yield Income Fund, and Muzinich Low Duration Fund (the “Funds”), hereby certifies that the forms of Prospectus and Statement of Additional Information that would have been filed under Rule 497(b) or (c) would not have differed from that contained in the most recent amendment for the Funds dated April 30, 2024, and filed electronically as Post-Effective Amendment No. 871 to the Trust’s Registration Statement on Form N-1A on April 29, 2024.

If you have any questions regarding the enclosed, please do not hesitate to contact the undersigned at (414) 516-1716 or carl.gee@usbank.com.

Sincerely,

/s/ Carl G. Gee

Carl G. Gee, Esq.

Vice President & Secretary of the Trust