v3.23.2
License, Collaboration and Other Significant Agreements - U.S. Collaboration and License Agreement with Otsuka Pharmaceutical Co. Ltd. Narrative (Details)
$ in Thousands
1 Months Ended 12 Months Ended
Dec. 31, 2016
USD ($)
Jul. 31, 2022
USD ($)
Dec. 31, 2022
USD ($)
performance_obligation
Dec. 31, 2021
USD ($)
Dec. 31, 2020
USD ($)
Apr. 01, 2019
Mar. 31, 2019
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]              
Total revenues     $ 292,484 $ 211,650 $ 294,644    
Revenue recognized     29,574 23,364 36,032    
Non-cash collaboration revenue     9,550 0 0    
License, collaboration and other revenue              
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]              
Total revenues     $ 115,535 71,362 166,406    
Otsuka Pharmaceutical Co. Ltd. | Otsuka U.S. Agreement              
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]              
Number of performance obligations | performance_obligation     3        
Percentage of costs funded by customer           80.00% 52.50%
Reimbursement for counterparty share of costs previously incurred $ 33,800            
Collaborative arrangements cost sharing payments     $ 319,200        
Cumulative catch-up adjustment to revenue, modification of contract   $ 55,000          
Revenue recognized     15,500        
Non-cash collaboration revenue     9,600        
Cost share costs incurred     7,600 17,500 5,100    
Reimbursable by Otsuka     3,800 8,600 2,200    
Cost share costs by partner for license agreement     0 900 2,100    
Reimbursable to Otsuka       400 1,100    
Otsuka Pharmaceutical Co. Ltd. | Otsuka U.S. Agreement | License, collaboration and other revenue              
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]              
Total revenues     86,773 $ 36,588 $ 93,446    
Otsuka Pharmaceutical Co. Ltd. | Development and Commercialize United States and International Collaboration and License Agreement | License, collaboration and other revenue              
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]              
Total revenues     92,300        
Otsuka Pharmaceutical Co. Ltd. | Up-front, Non-refundable and Non-creditable | Otsuka U.S. Agreement              
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]              
Upfront cash payment received     $ 125,000