License, Collaboration and Other Significant Agreements - Revenues Recognized From License, Collaboration and Other Significant Agreements (Details) - USD ($) $ in Thousands	12 Months Ended				36 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2022
License, Collaboration and Other Revenue:
Total revenues	$ 292,484	$ 211,650	$ 294,644
Mitsubishi Tanabe Pharma Corporation
License, Collaboration and Other Revenue:
Total revenues	1,800	800	400		$ 3,000
License, collaboration and other revenue
License, Collaboration and Other Revenue:
Total revenues	115,535	71,362	166,406
License, collaboration and other revenue \| Mitsubishi Tanabe Pharma Corporation
License, Collaboration and Other Revenue:
Total revenues	17,968	12,438	15,405	$ 10,000
License, collaboration and other revenue \| Otsuka Pharmaceutical Co. Ltd. \| Otsuka U.S. Agreement
License, Collaboration and Other Revenue:
Total revenues	86,773	36,588	93,446
License, collaboration and other revenue \| Otsuka Pharmaceutical Co. Ltd. \| Otsuka International Agreement
License, Collaboration and Other Revenue:
Total revenues	5,503	16,449	45,451
License, collaboration and other revenue \| Total Proportional Performance Revenue
License, Collaboration and Other Revenue:
Total revenues	110,244	65,475	154,302
License, collaboration and other revenue \| JT and Torii
License, Collaboration and Other Revenue:
Total revenues	5,291	5,814	5,681
License, collaboration and other revenue \| Other Revenue \| Mitsubishi Tanabe Pharma Corporation
License, Collaboration and Other Revenue:
Total revenues	$ 0	$ 73	$ 6,423