v3.23.2
Consolidated Statements of Operations and Comprehensive Loss - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Revenues:      
Total revenues $ 292,484 $ 211,650 $ 294,644
Cost of goods sold:      
Product 49,526 114,629 149,435
Amortization of intangible asset 36,042 36,042 32,617
Impairment of intangible asset 0 0 114,425
Total cost of goods sold 85,568 150,671 296,477
Operating expenses:      
Research and development 129,986 147,852 218,485
Selling, general and administrative 138,601 174,140 154,099
License expense 3,175 3,489 3,409
Restructuring 15,933 0 0
Total operating expenses 287,695 325,481 375,993
Operating loss (80,779) (264,502) (377,826)
Other income (expense):      
Interest income (expense) (15,687) (19,936) (8,871)
Other income (expense) 3,146 2,414 1,856
Loss on extinguishment of debt (906) 0 0
Net loss before income taxes (94,226) (282,024) (384,841)
Benefit from income taxes 0 0 0
Net loss $ (94,226) $ (282,024) $ (384,841)
Net loss per share - basic (in dollars per share) $ (0.52) $ (1.70) $ (2.78)
Net loss per share - diluted (in dollars per share) $ (0.52) $ (1.70) $ (2.78)
Weighted-average number of common shares - basic (in shares) 182,782,680 165,949,695 138,463,152
Weighted-average number of common shares - diluted (in shares) 182,782,680 165,949,695 138,463,152
Comprehensive loss:      
Net loss $ (94,226) $ (282,024) $ (384,841)
Other comprehensive (loss) gain - unrealized (loss) gain on securities 0 (7) 13
Total comprehensive loss (94,226) (282,031) (384,828)
Product revenue, net      
Revenues:      
Total revenues 176,949 140,288 128,238
License, collaboration and other revenue      
Revenues:      
Total revenues $ 115,535 $ 71,362 $ 166,406