Income Taxes - Additional Information (Detail) - USD ($) $ in Thousands |
12 Months Ended | |
|---|---|---|
Dec. 31, 2022 |
Dec. 31, 2021 |
|
| Income Taxes [Line Items] | ||
| Net operating loss carryforwards | $ 13,746 | $ 35,509 |
| Deferred tax assets related to U.S. federal research and development credits | $ 17,900 | |
| Net operating loss carryforwards beginning expiration year | 2035 | |
| U.S. research and development credit beginning expiration year | 2024 | |
| Orphan drug credit beginning expiration year | 2030 | |
| Deferred tax assets relating to U.S. state NOL carryforwards | $ 7,700 | |
| Unrecognized tax benefits that would impact effective tax rate | 15,500 | |
| U.S. Federal | ||
| Income Taxes [Line Items] | ||
| Net operating loss carryforwards | 6,100 | |
| Orphan Drug | ||
| Income Taxes [Line Items] | ||
| Net deferred tax assets | $ 24,500 | |
| District of Columbia | ||
| Income Taxes [Line Items] | ||
| Net operating loss carryforwards beginning expiration year | 2032 | |
| Other States | ||
| Income Taxes [Line Items] | ||
| Net operating loss carryforwards beginning expiration year | 2029 |