Commitments and Contingencies - CFTR Activators and Inhibitors - Additional Information (Detail) - CFTR Activators and Inhibitors - USD ($) $ in Thousands |
12 Months Ended | 70 Months Ended |
|---|---|---|
Dec. 31, 2022 |
Dec. 31, 2022 |
|
| CFTR activators and inhibitors | ||
| Tiered royalties payable on future net sales | single-digit | |
| Development and milestone payments to third party | $ 1,600 | |
| Development Milestone | ||
| CFTR activators and inhibitors | ||
| Possible future milestone payments | $ 11,900 | |
| Future Regulatory Approval And Sales Milestones | ||
| CFTR activators and inhibitors | ||
| Possible future milestone payments | 33,000 | |
| Development And Milestone Payment | ||
| CFTR activators and inhibitors | ||
| Possible future milestone payments | 1,100 | |
| Development And Milestone Payment | Maximum | ||
| CFTR activators and inhibitors | ||
| Possible future milestone payments | $ 3,200 |