EXHIBIT 4.1
Consent of Independent Registered Public Accounting Firm
We consent to the reference to our firm under the caption “Experts-Independent Registered Public Accounting Firm” and to the use of our report dated December 8, 2022 in the Amendment No. 1 to the Registration Statement (File No. 333-268208) and related Prospectus of Guggenheim Defined Portfolios, Series 2278.
/s/ Grant Thornton LLP
GRANT THORNTON LLP
Chicago, Illinois
December 8, 2022