CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We consent to the use in this Registration Statement No. 333-268547 on Form S-6 of our report dated December 8, 2022, relating to the financial statement of FT 10481, comprising Corporate Investment Grade Laddered Portfolio, Series 21, one of the series constituting the FT Series, appearing in the Prospectus, which is a part of such Registration Statement, and to the reference to us under the heading "Experts" in such Prospectus.

/s/ DELOITTE & TOUCHE LLP

Chicago, Illinois

December 8, 2022