American Funds Insurance Series® - Portfolio
Series
American Funds® Global Growth Portfolio
Investment portfolio
September 30, 2022
unaudited
Growth funds 80.07%   Shares Value
(000)
American Funds Insurance Series - Global Growth Fund, Class 1 636,218 $17,203
American Funds Insurance Series - Growth Fund, Class 1 153,772 11,495
American Funds Insurance Series - Global Small Capitalization Fund, Class 11 584,753 8,619
American Funds Insurance Series - International Fund, Class 1 419,794 5,797
American Funds Insurance Series - New World Fund, Class 1 141,491 2,901
Total growth funds (cost: $60,581,000)     46,015
Growth-and-income funds 20.02%      
American Funds Insurance Series - Capital World Growth and Income Fund, Class 1 1,093,652 11,505
Total growth-and-income funds (cost: $14,623,000)     11,505
Total investment securities 100.09% (cost: $75,204,000)     57,520
Other assets less liabilities (0.09)%     (52)
Net assets 100.00%     $57,468
Investments in affiliates2

  Value of
affiliates at
1/1/2022
(000)
Additions
(000)
Reductions
(000)
Net
realized
loss
(000)
  Net
unrealized
depreciation
(000)
  Value of
affiliates at
9/30/2022
(000)
  Dividend
income
(000)
  Capital gain
distributions
received
(000)
Growth funds 80.07%
American Funds Insurance Series -
Global Growth Fund, Class 1
$25,184 $3,712 $929 $(154)   $(10,610)   $17,203   $48   $2,268
American Funds Insurance Series -
Growth Fund, Class 1
16,742 3,399 1,446 (388)   (6,812)   11,495   20   1,931
American Funds Insurance Series -
Global Small Capitalization Fund, Class 11
12,680 4,344 418 (142)   (7,845)   8,619     3,329
American Funds Insurance Series -
International Fund, Class 1
8,437 1,377 665 (142)   (3,210)   5,797   32   900
American Funds Insurance Series -
New World Fund, Class 1
4,217 458 250 (56)   (1,468)   2,901   17   300
                46,015        
Growth-and-income funds 20.02%
American Funds Insurance Series -
Capital World Growth and Income Fund, Class 1
16,853 3,777 1,839 (71)   (7,215)   11,505   78   2,897
Total 100.09%       $(953)   $(37,160)   $57,520   $195   $11,625
1 Fund did not produce income during the last 12 months.
2 Part of the same “group of investment companies“ as the fund as defined under the Investment Company Act of 1940, as amended.
American Funds Insurance Series — Portfolio Series — Page 1 of 13

American Funds® Growth and Income Portfolio
Investment portfolio
September 30, 2022
unaudited
Growth funds 9.74%   Shares Value
(000)
American Funds Insurance Series - Growth Fund, Class 1 391,557 $29,269
Total growth funds (cost: $30,345,000)     29,269
Growth-and-income funds 39.57%      
American Funds Insurance Series - Capital World Growth and Income Fund, Class 1 5,659,164 59,534
American Funds Insurance Series - Growth-Income Fund, Class 1 1,289,099 59,350
Total growth-and-income funds (cost: $147,351,000)     118,884
Asset allocation funds 9.93%      
American Funds Insurance Series - Asset Allocation Fund, Class 1 1,440,889 29,841
Total asset allocation funds (cost: $40,800,000)     29,841
Equity-income funds 9.96%      
American Funds Insurance Series - Capital Income Builder, Series 1 2,991,256 29,912
Total equity-income funds (cost: $29,024,000)     29,912
Fixed income funds 30.89%      
American Funds Insurance Series - The Bond Fund of America, Class 1 9,799,007 92,797
Total fixed income funds (cost: $110,099,000)     92,797
Total investment securities 100.09% (cost: $357,619,000)     300,703
Other assets less liabilities (0.09)%     (267)
Net assets 100.00%     $300,436
American Funds Insurance Series — Portfolio Series — Page 2 of 13

unaudited
Investments in affiliates1

  Value of
affiliates at
1/1/2022
(000)
Additions
(000)
Reductions
(000)
Net
realized
loss
(000)
  Net
unrealized
depreciation
(000)
  Value of
affiliates at
9/30/2022
(000)
  Dividend
income
(000)
  Capital gain
distributions
received
(000)
Growth funds 9.74%
American Funds Insurance Series -
Growth Fund, Class 1
$37,645 $10,671 $1,769 $(467)   $(16,811)   $29,269   $49   $4,750
Growth-and-income funds 39.57%
American Funds Insurance Series -
Capital World Growth and Income Fund, Class 1
75,361 21,433 1,435 (539)   (35,286)   59,534   396   14,711
American Funds Insurance Series -
Growth-Income Fund, Class 1
75,346 11,363 2,296 (353)   (24,710)   59,350   206   6,454
                118,884        
Asset allocation funds 9.93%
American Funds Insurance Series -
Asset Allocation Fund, Class 1
37,647 3,591 141 (38)   (11,218)   29,841   147   3,432
Equity-income funds 9.96%
American Funds Insurance Series -
Capital Income Builder, Series 1
37,800 764 2,169 (9)   (6,474)   29,912   601  
Fixed income funds 30.89%
American Funds Insurance Series -
The Bond Fund of America, Class 1
113,219 8,865 11,916 (1,114)   (16,257)   92,797   582   1,144
Total 100.09%       $(2,520)   $(110,756)   $300,703   $1,981   $30,491
1 Part of the same “group of investment companies“ as the fund as defined under the Investment Company Act of 1940, as amended.
American Funds Insurance Series — Portfolio Series — Page 3 of 13

American Funds® Managed Risk Growth Portfolio
Investment portfolio
September 30, 2022
unaudited
Growth funds 54.39%   Shares Value
(000)
American Funds Insurance Series – Growth Fund, Class 1 6,228,135 $465,553
American Funds Insurance Series – Global Growth Fund, Class 1 8,608,601 232,777
American Funds Insurance Series – Global Small Capitalization Fund, Class 11 10,534,676 155,281
Total growth funds (cost: $1,160,346,000)     853,611
Growth-and-income funds 19.78%      
American Funds Insurance Series – Growth-Income Fund, Class 1 5,055,964 232,776
American Funds Insurance Series – Washington Mutual Investors Fund, Class 1 6,739,632 77,641
Total growth-and-income funds (cost: $361,644,000)     310,417
Fixed income funds 18.30%      
American Funds Insurance Series – The Bond Fund of America, Class 1 30,327,087 287,197
Total fixed income funds (cost: $323,676,000)     287,197
Short-term securities 3.40%      
State Street Institutional U.S. Government Money Market Fund, Premier Class 2.94%2 53,311,789 53,312
Total short-term securities (cost: $53,312,000)     53,312
Options purchased 0.61%      
Options purchased*     9,530
Total options purchased (cost: $5,517,000)     9,530
Total investment securities 96.48% (cost: $1,904,495,000)     1,514,067
Other assets less liabilities 3.52%     55,292
Net assets 100.00%     $1,569,359
*Options purchased

Put
Description Number of
contracts
Notional
amount
(000)
Exercise
price
Expiration
date
Value at
9/30/2022
(000)
S&P 500 Index 40 USD14,343 USD2,650.00 12/16/2022 $70
S&P 500 Index 230 82,470 2,675.00 12/16/2022 421
S&P 500 Index 50 17,928 2,725.00 12/16/2022 100
S&P 500 Index 260 93,226 2,700.00 3/17/2023 1,217
S&P 500 Index 520 186,452 2,800.00 3/17/2023 2,922
American Funds Insurance Series — Portfolio Series — Page 4 of 13

unaudited
*Options purchased  (continued)

Put  (continued)
Description Number of
contracts
Notional
amount
(000)
Exercise
price
Expiration
date
Value at
9/30/2022
(000)
S&P 500 Index 390 USD139,839 USD2,850.00 3/17/2023 $2,387
S&P 500 Index 365 130,875 2,900.00 3/17/2023 2,413
          $9,530
Futures contracts

Contracts Type Number of
contracts
Expiration Notional
amount
(000)
Value and
unrealized
(depreciation)
appreciation
at 9/30/2022
(000)
5 Year U.S. Treasury Note Futures Long 1,009 December 2022 USD108,475 $(3,656)
Nikkei 225 Index Contracts Short 64 December 2022 (11,451) 536
Japanese Yen Currency Contracts Short 138 December 2022 (12,012) 55
FTSE 100 Index Contracts Short 235 December 2022 (17,952) 1,458
British Pound Currency Contracts Short 282 December 2022 (19,707) 447
Russell 2000 Mini Index Contracts Short 390 December 2022 (32,561) 3,077
S&P Mid 400 E-mini Index Contracts Short 262 December 2022 (57,855) 5,856
Mini MSCI Emerging Market Index Contracts Short 1,333 December 2022 (58,085) 6,122
Euro Stoxx 50 Index Contracts Short 1,924 December 2022 (61,896) 5,387
Euro Currency Contracts Short 554 December 2022 (68,291) 993
S&P 500 E-mini Index Contracts Short 2,775 December 2022 (499,708) 52,202
          $72,477
American Funds Insurance Series — Portfolio Series — Page 5 of 13

unaudited
Investments in affiliates3

  Value of
affiliates at
1/1/2022
(000)
Additions
(000)
Reductions
(000)
Net
realized
(loss) gain
(000)
  Net
unrealized
depreciation
(000)
  Value of
affiliates at
9/30/2022
(000)
  Dividend
income
(000)
  Capital gain
distributions
received
(000)
Growth funds 54.39%
American Funds Insurance Series –
Growth Fund, Class 1
$594,971 $483,127 $351,642 $(11,564)   $(249,339)   $465,553   $753   $73,126
American Funds Insurance Series –
Global Growth Fund, Class 1
298,430 160,738 94,969 (31,040)   (100,382)   232,777   608   28,510
American Funds Insurance Series –
Global Small Capitalization Fund, Class 11
198,324 165,680 78,459 (3,912)   (126,352)   155,281     55,512
                853,611        
Growth-and-income funds 19.78%
American Funds Insurance Series –
Growth-Income Fund, Class 1
298,430 132,110 103,116 25,252   (119,900)   232,776   779   24,366
American Funds Insurance Series –
Washington Mutual Investors Fund, Class 1
100,106 48,177 35,450 6,899   (42,091)   77,641   389   18,483
                310,417        
Fixed income funds 18.30%
American Funds Insurance Series –
The Bond Fund of America, Class 1
398,536 190,112 242,698 (38,370)   (20,383)   287,197   1,849   3,634
Total 92.47%       $(52,735)   $(658,447)   $1,451,225   $4,378   $203,631
1 Fund did not produce income during the last 12 months.
2 Rate represents the seven-day yield at 9/30/2022.
3 Part of the same “group of investment companies“ as the fund as defined under the Investment Company Act of 1940, as amended.
Key to abbreviation
USD = U.S. dollars
American Funds Insurance Series — Portfolio Series — Page 6 of 13

American Funds® Managed Risk Growth and Income Portfolio
Investment portfolio
September 30, 2022
unaudited
Growth funds 9.96%   Shares Value
(000)
American Funds Insurance Series – Growth Fund, Class 1 1,656,909 $123,854
Total growth funds (cost: $155,213,000)     123,854
Growth-and-income funds 49.74%      
American Funds Insurance Series – Capital World Growth and Income Fund, Class 1 29,410,962 309,403
American Funds Insurance Series – Growth-Income Fund, Class 1 6,720,315 309,403
Total growth-and-income funds (cost: $799,720,000)     618,806
Asset allocation funds 4.98%      
American Funds Insurance Series – Asset Allocation Fund, Class 1 2,990,196 61,927
Total asset allocation funds (cost: $80,720,000)     61,927
Equity-income funds 14.92%      
American Funds Insurance Series – Capital Income Builder Fund, Class 1 18,566,514 185,665
Total equity-income funds (cost: $197,032,000)     185,665
Fixed income funds 13.44%      
American Funds Insurance Series – The Bond Fund of America, Class 1 17,649,939 167,145
Total fixed income funds (cost: $187,305,000)     167,145
Short-term securities 3.07%      
State Street Institutional U.S. Government Money Market Fund, Premier Class 2.94%1 38,120,726 38,121
Total short-term securities (cost: $38,121,000)     38,121
Options purchased 0.59%      
Options purchased*     7,369
Total options purchased (cost: $4,810,000)     7,369
Total investment securities 96.70% (cost: $1,462,921,000)     1,202,887
Other assets less liabilities 3.30%     41,103
Net assets 100.00%     $1,243,990
American Funds Insurance Series — Portfolio Series — Page 7 of 13

unaudited
*Options purchased

Put
Description Number of
contracts
Notional
amount
(000)
Exercise
price
Expiration
date
Value at
9/30/2022
(000)
S&P 500 Index 90 USD32,271 USD2,375.00 12/16/2022 $90
S&P 500 Index 20 7,171 2,500.00 12/16/2022 26
S&P 500 Index 90 32,271 2,575.00 12/16/2022 134
S&P 500 Index 105 37,649 2,650.00 12/16/2022 183
S&P 500 Index 170 60,955 2,675.00 12/16/2022 311
S&P 500 Index 70 25,099 2,725.00 12/16/2022 141
S&P 500 Index 100 35,856 2,700.00 3/17/2023 468
S&P 500 Index 300 107,569 2,800.00 3/17/2023 1,686
S&P 500 Index 405 145,218 2,850.00 3/17/2023 2,479
S&P 500 Index 280 100,397 2,900.00 3/17/2023 1,851
          $7,369
Futures contracts

Contracts Type Number of
contracts
Expiration Notional
amount
(000)
Value and
unrealized
(depreciation)
appreciation
at 9/30/2022
(000)
5 Year U.S. Treasury Note Futures Long 924 December 2022 USD99,337 $(2,121)
Russell 2000 Mini Index Contracts Short 56 December 2022 (4,675) 452
Nikkei 225 Index Contracts Short 70 December 2022 (12,525) 595
Japanese Yen Currency Contracts Short 153 December 2022 (13,318) 61
FTSE 100 Index Contracts Short 316 December 2022 (24,140) 1,939
British Pound Currency Contracts Short 380 December 2022 (26,555) 599
S&P Mid 400 E-mini Index Contracts Short 159 December 2022 (35,110) 3,640
Mini MSCI Emerging Market Index Contracts Short 982 December 2022 (42,791) 4,247
Euro Stoxx 50 Index Contracts Short 1,709 December 2022 (54,979) 4,796
Euro Currency Contracts Short 513 December 2022 (63,237) 871
S&P 500 E-mini Index Contracts Short 2,068 December 2022 (372,395) 39,530
          $54,609
American Funds Insurance Series — Portfolio Series — Page 8 of 13

unaudited
Investments in affiliates2

  Value of
affiliates at
1/1/2022
(000)
Additions
(000)
Reductions
(000)
Net
realized
(loss) gain
(000)
  Net
unrealized
depreciation
(000)
  Value of
affiliates at
9/30/2022
(000)
  Dividend
income
(000)
  Capital gain
distributions
received
(000)
Growth funds 9.96%
American Funds Insurance Series –
Growth Fund, Class 1
$152,822 $147,485 $107,840 $(12,880)   $(55,733)   $123,854   $202   $19,581
Growth-and-income funds 49.74%
American Funds Insurance Series –
Capital World Growth and Income Fund, Class 1
382,784 251,662 147,740 16,294   (193,597)   309,403   1,963   72,892
American Funds Insurance Series –
Growth-Income Fund, Class 1
382,784 218,530 168,136 37,797   (161,572)   309,403   1,033   32,314
                618,806        
Asset allocation funds 4.98%
American Funds Insurance Series –
Asset Allocation Fund, Class 1
77,139 25,195 18,056 (3,006)   (19,345)   61,927   293   6,848
Equity-income funds 14.92%
American Funds Insurance Series –
Capital Income Builder Fund, Class 1
229,961 61,166 67,237 13,928   (52,153)   185,665   3,588  
Fixed income funds 13.44%
American Funds Insurance Series –
The Bond Fund of America, Class 1
229,961 119,393 147,337 (23,792)   (11,080)   167,145   1,126   2,213
Total 93.04%       $28,341   $(493,480)   $1,157,397   $8,205   $133,848
1 Rate represents the seven-day yield at 9/30/2022.
2 Part of the same “group of investment companies“ as the fund as defined under the Investment Company Act of 1940, as amended.
Key to abbreviation
USD = U.S. dollars
American Funds Insurance Series — Portfolio Series — Page 9 of 13

American Funds® Managed Risk Global Allocation Portfolio
Investment portfolio
September 30, 2022
unaudited
Growth funds 24.77%   Shares Value
(000)
American Funds Insurance Series – Global Growth Fund, Class 1 3,411,780 $92,255
Total growth funds (cost: $122,730,000)     92,255
Growth-and-income funds 19.83%      
American Funds Insurance Series – Capital World Growth and Income Fund, Class 1 7,018,193 73,831
Total growth-and-income funds (cost: $96,508,000)     73,831
Asset allocation funds 9.91%      
American Funds Insurance Series – Asset Allocation Fund, Class 1 1,782,506 36,916
Total asset allocation funds (cost: $42,245,000)     36,916
Balanced funds 24.77%      
American Funds Insurance Series – American Funds Global Balanced Fund, Class 1 8,078,331 92,255
Total balanced funds (cost: $105,379,000)     92,255
Fixed income funds 13.87%      
American Funds Insurance Series – Capital World Bond Fund, Class 1 5,733,757 51,661
Total fixed income funds (cost: $63,416,000)     51,661
Short-term securities 3.07%      
State Street Institutional U.S. Government Money Market Fund, Premier Class 2.94%1 11,443,465 11,443
Total short-term securities (cost: $11,443,000)     11,443
Options purchased 0.63%      
Options purchased*     2,340
Total options purchased (cost: $1,361,000)     2,340
Total investment securities 96.85% (cost: $443,082,000)     360,701
Other assets less liabilities 3.15%     11,750
Net assets 100.00%     $372,451
American Funds Insurance Series — Portfolio Series — Page 10 of 13

unaudited
*Options purchased

Put
Description Number of
contracts
Notional
amount
(000)
Exercise
price
Expiration
date
Value at
9/30/2022
(000)
S&P 500 Index 30 USD10,757 USD2,650.00 12/16/2022 $52
S&P 500 Index 55 19,721 2,675.00 12/16/2022 101
S&P 500 Index 20 7,171 2,725.00 12/16/2022 40
S&P 500 Index 35 12,550 2,700.00 3/17/2023 164
S&P 500 Index 95 34,063 2,800.00 3/17/2023 534
S&P 500 Index 145 51,991 2,850.00 3/17/2023 887
S&P 500 Index 85 30,478 2,900.00 3/17/2023 562
          $2,340
Futures contracts

Contracts Type Number of
contracts
Expiration Notional
amount
(000)
Value and
unrealized
(depreciation)
appreciation
at 9/30/2022
(000)
5 Year U.S. Treasury Note Futures Long 215 December 2022 USD23,114 $(786)
Russell 2000 Mini Index Contracts Short 21 December 2022 (1,753) 167
Nikkei 225 Index Contracts Short 27 December 2022 (4,831) 231
Japanese Yen Currency Contracts Short 59 December 2022 (5,136) 32
S&P Mid 400 E-mini Index Contracts Short 32 December 2022 (7,066) 697
FTSE 100 Index Contracts Short 117 December 2022 (8,938) 708
British Pound Currency Contracts Short 140 December 2022 (9,783) 208
Mini MSCI Emerging Market Index Contracts Short 514 December 2022 (22,398) 2,242
Euro Stoxx 50 Index Contracts Short 932 December 2022 (29,983) 2,485
Euro Currency Contracts Short 278 December 2022 (34,269) 439
S&P 500 E-mini Index Contracts Short 442 December 2022 (79,593) 8,376
          $14,799
American Funds Insurance Series — Portfolio Series — Page 11 of 13

unaudited
Investments in affiliates2

  Value of
affiliates at
1/1/2022
(000)
Additions
(000)
Reductions
(000)
Net
realized
(loss) gain
(000)
  Net
unrealized
depreciation
(000)
  Value of
affiliates at
9/30/2022
(000)
  Dividend
income
(000)
  Capital gain
distributions
received
(000)
Growth funds 24.77%
American Funds Insurance Series –
Global Growth Fund, Class 1
$120,215 $85,094 $60,518 $(4,383)   $(48,153)   $92,255   $247   $11,561
Growth-and-income funds 19.83%
American Funds Insurance Series –
Capital World Growth and Income Fund, Class 1
96,446 57,489 36,691 2,900   (46,313)   73,831   479   17,806
Asset allocation funds 9.91%
American Funds Insurance Series –
Asset Allocation Fund, Class 1
47,995 15,204 12,705 583   (14,161)   36,916   178   4,164
Balanced funds 24.77%
American Funds Insurance Series –
American Funds Global Balanced Fund, Class 1
120,215 27,371 29,265 85   (26,151)   92,255     568
Fixed income funds 13.87%
American Funds Insurance Series –
Capital World Bond Fund, Class 1
72,221 33,092 36,795 (7,739)   (9,118)   51,661   181   987
Total 93.15%       $(8,554)   $(143,896)   $346,918   $1,085   $35,086
1 Rate represents the seven-day yield at 9/30/2022.
2 Part of the same “group of investment companies“ as the fund as defined under the Investment Company Act of 1940, as amended.
Key to abbreviation
USD = U.S. dollars
American Funds Insurance Series — Portfolio Series — Page 12 of 13

unaudited
Valuation disclosures

Security valuation — The net asset value of each share class of each fund is calculated based on the reported net asset values of the underlying funds in which each fund invests. The net asset value of each underlying fund is calculated based on the policies and procedures of the underlying fund contained in each underlying fund’s statement of additional information. The net asset value per share of each fund and each underlying fund is calculated once daily as of the close of regular trading on the New York Stock Exchange, normally 4 p.m. New York time, each day the New York Stock Exchange is open. The State Street Institutional U.S. Government Money Market Fund held by the managed risk funds is managed to maintain a $1.00 net asset value per share. Exchange-traded options and futures are generally valued at the official closing price for options and official settlement price for futures of the exchange or market on which such instruments are traded, as of the close of business on the day such instruments are being valued. The average month-end notional amount of option contracts while held by Managed Risk Growth Portfolio, Managed Risk Growth and Income Portfolio and Managed Risk Global Allocation Portfolio was $1,117,937,000, $992,434,000 and $264,311,000, respectively. The average month-end notional amount of futures contracts while held by Managed Risk Growth Portfolio, Managed Risk Growth and Income Portfolio and Managed Risk Global Allocation Portfolio was $992,851,000, $1,175,587,000 and $406,999,000, respectively.
Processes and structure — The series’ board of trustees has designated the series’ investment adviser to make fair value determinations, subject to board oversight. The investment adviser has established a Joint Fair Valuation Committee (the “Fair Valuation Committee”) to administer, implement and oversee the fair valuation process, and to make fair value decisions. The Fair Valuation Committee regularly reviews its own fair value decisions, as well as decisions made under its standing instructions to the investment adviser’s valuation team. The Fair Valuation Committee reviews changes in fair value measurements from period to period and may, as deemed appropriate, update the fair valuation guidelines to better reflect the results of back testing and address new or evolving issues. The Fair Valuation Committee reports any changes to the fair valuation guidelines to the board of trustees. The series’ board and audit committee also regularly review reports that describe fair value determinations and methods. Pricing decisions, processes and controls over security valuation are also subject to additional internal reviews facilitated by the investment adviser’s global risk management group.
Classifications — The series’ investment adviser classifies each fund’s assets and liabilities into three levels based on the method used to value the assets or liabilities. Level 1 values are based on quoted prices in active markets for identical securities. Level 2 values are based on significant observable market inputs, such as quoted prices for similar securities and quoted prices in inactive markets. Level 3 values are based on significant unobservable inputs that reflect the investment adviser’s determination of assumptions that market participants might reasonably use in valuing the securities. The valuation levels are not necessarily an indication of the risk or liquidity associated with the underlying investment.
At September 30, 2022, all of the investments held by each fund were classified as Level 1.
Investments are not FDIC-insured, nor are they deposits of or guaranteed by a bank or any other entity, so they may lose value.
Investors should carefully consider investment objectives, risks, charges and expenses. This and other important information is contained in the series prospectus and summary prospectuses, which can be obtained from your financial professional and should be read carefully before investing. You may also call American Funds Service Company (AFS) at (800) 421-4225 or visit the American Funds website at capitalgroup.com. Fund shares offered through American Funds Distributors, Inc.
All Capital Group trademarks mentioned are owned by The Capital Group Companies, Inc., an affiliated company or fund. All other company and product names mentioned are the property of their respective companies.
American Funds Distributors, Inc., member FINRA.
© 2022 Capital Group. All rights reserved.
INGEFP3-875-1122O-S89753 American Funds Insurance Series — Portfolio Series — Page 13 of 13