v3.22.2.2
Cover - shares
 9 Months Ended
Sep. 30, 2022
Nov. 04, 2022
Cover [Abstract]    
Document Type 10-Q  
Document Quarterly Report true  
Document Period End Date Sep. 30, 2022  
Document Transition Report false  
Entity File Number 001-35670  
Entity Registrant Name Regulus Therapeutics Inc.  
Entity Incorporation, State or Country Code DE  
Entity Tax Identification Number 26-4738379  
Entity Address, Address Line One 4224 Campus Point Court, Suite 210  
Entity Address, City or Town San Diego  
Entity Address, State or Province CA  
Entity Address, Postal Zip Code 92121  
City Area Code 858  
Local Phone Number 202-6300  
Title of 12(b) Security Common Stock, par value $0.001 per share  
Trading Symbol RGLS  
Security Exchange Name NASDAQ  
Entity Current Reporting Status Yes  
Entity Interactive Data Current Yes  
Entity Filer Category Non-accelerated Filer  
Entity Small Business true  
Entity Emerging Growth Company false  
Entity Shell Company false  
Entity Common Stock, Shares Outstanding   16,840,261
Amendment Flag false  
Document Fiscal Year Focus 2022  
Document Fiscal Period Focus Q3  
Entity Central Index Key 0001505512  
Current Fiscal Year End Date --12-31