v3.22.2.2
Consolidated Statements of Cash Flows
$ in Thousands
9 Months Ended
Sep. 30, 2022
USD ($)
Sep. 30, 2021
USD ($)
Cash flows from operating activities    
Net loss $ (388,128) $ (380,636)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 89,971 45,323
Non-cash operating lease expense 7,505 5,516
Non-cash royalty revenue related to sale of future royalties (31,617) (14,317)
Non-cash interest expense on liability related to sale of future royalties 55,778 57,755
Change in valuation of deferred and contingent consideration (32,200) 11,600
Unrealized loss (gain) on ClearPoint Equity Investments 1,113 (2,376)
Unrealized loss (gain) on ClearPoint convertible debt security 2,392 (2,054)
Unrealized loss (gain) on marketable securities - equity investments 11,319 (1,350)
Loss on disposal of asset 81  
Amortization of premiums on investments, net 1,792 4,052
Amortization of debt issuance costs 1,316 1,377
Share-based compensation expense 82,989 77,277
Unrealized foreign currency transaction losses, net 71,246 33,280
Changes in operating assets and liabilities:    
Inventory, net (768) 2,476
Prepaid expenses and other current assets (35,615) 8,161
Trade and royalty receivables, net (24,773) (28,625)
Deposits and other assets (3,752) (444)
Accounts payable and accrued expenses 1,568 8,888
Other liabilities (908) (4,340)
Deferred revenue   (4,055)
Net cash used in operating activities (190,691) (182,492)
Cash flows from investing activities    
Purchases of fixed assets (23,394) (19,487)
Purchases of marketable securities - available for sale (40,429) (276,376)
Purchases of marketable securities - equity investments (22,787) (205,382)
Sale and redemption of marketable securities- available for sale 341,990 693,319
Sale and redemption of marketable securities - equity investments 104,431 740
Acquisition of product rights and licenses (102,069) (41,806)
Purchase of equity investment in ClearPoint   (100)
Net cash provided by investing activities 257,742 150,908
Cash flows from financing activities    
Proceeds from exercise of options 13,203 16,120
Repayment of Convertible Notes (150,000)  
Proceeds from employee stock purchase plan 3,107 2,627
Payment of finance lease principal (1,276) (2,224)
Net cash provided by financing activities (134,966) 16,523
Effect of exchange rate changes on cash (8,792) (3,933)
Net decrease in cash and cash equivalents (76,707) (18,994)
Cash and cash equivalents, and restricted cash beginning of period 197,218 216,312
Cash and cash equivalents, and restricted cash end of period 120,511 197,318
Supplemental disclosure of cash information    
Cash paid for interest 12,679 9,589
Cash paid for income taxes 4,029 5,527
Supplemental disclosure of non-cash investing and financing activity    
Unrealized loss on marketable securities, net of tax (2,333) (1,505)
Right-of-use assets obtained in exchange for operating lease obligations 35,294  
Acquisition of product rights and licenses 27,828 $ 19,154
Milestone payable $ 50,000