v3.22.2.2
Intangible assets and goodwill - Narrative (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 9 Months Ended 49 Months Ended
Apr. 20, 2017
Jul. 31, 2022
Aug. 31, 2021
Dec. 31, 2019
May 31, 2019
Sep. 30, 2022
Sep. 30, 2021
Sep. 30, 2022
Sep. 30, 2021
Sep. 30, 2022
Dec. 31, 2021
Aug. 23, 2018
Finite-Lived Intangible Assets                        
Milestone payable           $ 50,000   $ 50,000   $ 50,000    
Amortization of intangible assets           31,023 $ 14,383 80,790 $ 38,411      
Accrued royalties           41,897   41,897   41,897 $ 35,679  
Goodwill           82,341   82,341   82,341 $ 82,341  
Changes in goodwill                   0    
Tegsedi                        
Finite-Lived Intangible Assets                        
Royalty payments           500 0 $ 2,500 0      
Weighted Average                        
Finite-Lived Intangible Assets                        
Remaining amortization period               5 years 1 month 6 days        
Accounts payable and accrued expenses | Tegsedi                        
Finite-Lived Intangible Assets                        
Accrued royalties           500   $ 500   500    
Akcea                        
Finite-Lived Intangible Assets                        
Milestone payments     $ 4,000                  
Marathon                        
Finite-Lived Intangible Assets                        
Milestone payments received           50,000   50,000   50,000    
Agilis                        
Finite-Lived Intangible Assets                        
Finite-lived intangibles   $ 89,500                    
Useful life   12 years                    
Indefinite-lived intangible assets acquired                       $ 576,500
Reclassification out of indefinite-lived intangible assets on successful completion of R&D efforts   $ 89,500                    
Indefinite-lived intangible assets           487,000   487,000   487,000    
Goodwill                       $ 82,300
Agilis | Accounts payable and accrued expenses                        
Finite-Lived Intangible Assets                        
Milestone payable           50,000   50,000   50,000    
Agilis Merger Agreement | Akcea                        
Finite-Lived Intangible Assets                        
Milestone payments       $ 4,000 $ 6,000              
Useful life       10 years                
Agilis Merger Agreement | Marathon                        
Finite-Lived Intangible Assets                        
Milestone obligation payments made               50,000        
Emflaza asset acquisition                        
Finite-Lived Intangible Assets                        
Finite-lived intangibles $ 148,400                      
Milestone obligation payments recorded           21,300 $ 16,800 105,100 $ 42,800      
Useful life 7 years                      
Emflaza asset acquisition | Accounts payable and accrued expenses                        
Finite-Lived Intangible Assets                        
Milestone payable           $ 27,400   $ 27,400   $ 27,400