Stock award plan - Share-based compensation expense (Details) - USD ($) $ in Thousands |
3 Months Ended | 9 Months Ended | ||
|---|---|---|---|---|
Sep. 30, 2022 |
Sep. 30, 2021 |
Sep. 30, 2022 |
Sep. 30, 2021 |
|
| Stock option plan | ||||
| Share-based compensation expense | $ 28,670 | $ 25,871 | $ 82,989 | $ 77,277 |
| Unrecognized compensation cost | 200,600 | $ 200,600 | ||
| Weighted average remaining service period for recognition of unrecognized compensation cost | 2 years 3 months 25 days | |||
| Research and development | ||||
| Stock option plan | ||||
| Share-based compensation expense | 15,063 | 13,048 | $ 41,896 | 40,216 |
| Selling, general and administrative | ||||
| Stock option plan | ||||
| Share-based compensation expense | $ 13,607 | $ 12,823 | $ 41,093 | $ 37,061 |