v3.22.2.2
Fair value of financial instruments and investments - Fair Value Liabilities Measured (Details) - Agilis - Commitments
$ in Thousands
Sep. 30, 2022
USD ($)
Dec. 31, 2021
USD ($)
Sep. 30, 2021
USD ($)
Dec. 31, 2020
USD ($)
Development and Regulatory Milestones | Valuation Technique, Discounted Cash Flow | Development and Regulatory Milestone | Minimum        
Fair Value Valuation Inputs        
Potential milestones $ 0 $ 0    
Development and Regulatory Milestones | Valuation Technique, Discounted Cash Flow | Development and Regulatory Milestone | Maximum        
Fair Value Valuation Inputs        
Potential milestones $ 331,000 $ 381,000    
Development and Regulatory Milestones | Valuation Technique, Discounted Cash Flow | Probability of Success | Minimum        
Fair Value Valuation Inputs        
Rights Exchange Settlement measurement 0.25 0.25    
Development and Regulatory Milestones | Valuation Technique, Discounted Cash Flow | Probability of Success | Maximum        
Fair Value Valuation Inputs        
Rights Exchange Settlement measurement 0.87 0.94    
Development and Regulatory Milestones | Valuation Technique, Discounted Cash Flow | Probability of Success | Weighted Average        
Fair Value Valuation Inputs        
Rights Exchange Settlement measurement 0.34      
Development and Regulatory Milestones | Valuation Technique, Discounted Cash Flow | Measurement Input, Discount Rate | Minimum        
Fair Value Valuation Inputs        
Rights Exchange Settlement measurement 0.068 0.017    
Development and Regulatory Milestones | Valuation Technique, Discounted Cash Flow | Measurement Input, Discount Rate | Maximum        
Fair Value Valuation Inputs        
Rights Exchange Settlement measurement 0.091 0.047    
Development and Regulatory Milestones | Valuation Technique, Discounted Cash Flow | Measurement Input, Discount Rate | Weighted Average        
Fair Value Valuation Inputs        
Rights Exchange Settlement measurement 0.086      
Development and Regulatory Milestones | Significant unobservable inputs (Level 3)        
Fair Value Valuation Inputs        
Fair value $ 78,500 $ 139,300 $ 140,200 $ 139,200
Net Sales Milestones and Royalties | Valuation Technique, Option Pricing Model | Sales Milestones | Minimum        
Fair Value Valuation Inputs        
Potential milestones 0 0    
Net Sales Milestones and Royalties | Valuation Technique, Option Pricing Model | Sales Milestones | Maximum        
Fair Value Valuation Inputs        
Potential milestones $ 150,000 $ 150,000    
Net Sales Milestones and Royalties | Valuation Technique, Option Pricing Model | Probability of Success | Minimum        
Fair Value Valuation Inputs        
Rights Exchange Settlement measurement 0.25 0.25    
Net Sales Milestones and Royalties | Valuation Technique, Option Pricing Model | Probability of Success | Maximum        
Fair Value Valuation Inputs        
Rights Exchange Settlement measurement 1 0.94    
Net Sales Milestones and Royalties | Valuation Technique, Option Pricing Model | Probability of Success | Weighted Average        
Fair Value Valuation Inputs        
Rights Exchange Settlement measurement 0.49      
Net Sales Milestones and Royalties | Valuation Technique, Option Pricing Model | Percentage of Sales for Royalties | Minimum        
Fair Value Valuation Inputs        
Rights Exchange Settlement measurement 0.02 0.02    
Net Sales Milestones and Royalties | Valuation Technique, Option Pricing Model | Percentage of Sales for Royalties | Maximum        
Fair Value Valuation Inputs        
Rights Exchange Settlement measurement 0.06 0.06    
Net Sales Milestones and Royalties | Valuation Technique, Option Pricing Model | Measurement Input, Discount Rate        
Fair Value Valuation Inputs        
Rights Exchange Settlement measurement 0.125 0.110    
Net Sales Milestones and Royalties | Valuation Technique, Option Pricing Model | Measurement Input, Discount Rate | Weighted Average        
Fair Value Valuation Inputs        
Rights Exchange Settlement measurement 0.125      
Net Sales Milestones and Royalties | Significant unobservable inputs (Level 3)        
Fair Value Valuation Inputs        
Fair value $ 79,200 $ 100,600 $ 111,800 $ 101,200