Fair value of financial instruments and investments - Summary of changes in the fair value of the Company's Level 3 valuation (Details) - Significant unobservable inputs (Level 3) - Agilis - Commitments - USD ($) $ in Thousands |
9 Months Ended | |
|---|---|---|
Sep. 30, 2022 |
Sep. 30, 2021 |
|
| Development and Regulatory Milestones | ||
| Changes in the fair value of warrant liability and SARs liability | ||
| Beginning Balance | $ 139,300 | $ 139,200 |
| Additions | 0 | 0 |
| Change in fair value | (10,800) | 1,000 |
| Reclass to accounts payable and accrued expenses | (50,000) | |
| Rights Exchange settlement | 0 | 0 |
| Ending Balance | 78,500 | 140,200 |
| Net Sales Milestones and Royalties | ||
| Changes in the fair value of warrant liability and SARs liability | ||
| Beginning Balance | 100,600 | 101,200 |
| Additions | 0 | 0 |
| Change in fair value | (21,400) | 10,600 |
| Reclass to accounts payable and accrued expenses | 0 | |
| Rights Exchange settlement | 0 | 0 |
| Ending Balance | $ 79,200 | $ 111,800 |