Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise.

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Summary of significant accounting policies - Collaboration and Royalty Revenue (Details) - USD ($) $ in Thousands	1 Months Ended	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021	Aug. 31, 2021	Mar. 31, 2021
Collaboration and royalty revenue
Revenue		$ 217,127	$ 138,743	$ 531,389	$ 373,364
Collaboration and grant revenue
Collaboration and royalty revenue
Revenue		50,017	10,011	50,024	30,018
Royalty revenue
Collaboration and royalty revenue
Revenue		32,924	13,127	73,645	33,348
SMA License Agreement \| Collaboration and grant revenue
Collaboration and royalty revenue
Revenue		50,000	10,000	50,000	30,000
SMA License Agreement \| Royalty revenue
Collaboration and royalty revenue
Revenue		$ 32,900	13,100	$ 73,600	33,300
SMA License Agreement \| Sales Milestones
Collaboration and royalty revenue
Milestone payments received			$ 20,000		$ 20,000	$ 10,000	$ 20,000
Net sales milestone threshold achieved	$ 750,000
SMA License Agreement \| Sales Milestones \| Prepaids and other current assets
Collaboration and royalty revenue
Milestone payments due	$ 50,000