NPORT-P
false
0001329377
XXXXXXXX
S000012478
C000033929
First Trust Exchange-Traded Fund
811-21774
0001329377
549300MZB4XDLRWOC672
120 East Liberty Drive
Suite 400
Wheaton
60187
630-765-8000
First Trust NYSE Arca Biotechnology Index Fund
S000012478
5493003ZQM0TVLDIBC50
2022-12-31
2022-06-30
N
1275660140.64
925458.05
1274734682.59
0.00000000
0.00000000
0.00000000
0.00000000
0.00000000
0.00000000
0.00000000
0.00000000
0.00000000
0.00000000
0.00000000
0.00000000
0.00000000
1473860.23000000
N
ACADIA Pharmaceuticals Inc
529900O3044NO0PEA039
ACADIA Pharmaceuticals Inc
004225108
2044434.00000000
NS
USD
28806075.06000000
2.259770245010
Long
EC
CORP
US
N
1
N
N
N
Exelixis Inc
254900PJQB59O2O95R37
Exelixis Inc
30161Q104
2077918.00000000
NS
USD
43262252.76000000
3.393824091465
Long
EC
CORP
US
N
1
N
N
N
Grifols SA
959800HSSNXWRKBK4N60
Grifols SA
398438408
4459115.00000000
NS
USD
52974286.20000000
4.155710746989
Long
EC
CORP
ES
N
1
N
N
N
Vertex Pharmaceuticals Inc
54930015RAQRRZ5ZGJ91
Vertex Pharmaceuticals Inc
92532F100
166650.00000000
NS
USD
46960303.50000000
3.683927655014
Long
EC
CORP
US
N
1
N
N
N
Seagen Inc
N/A
Seagen Inc
81181C104
320598.00000000
NS
USD
56726610.12000000
4.450071916513
Long
EC
CORP
US
N
1
N
N
N
Bio-Techne Corp
54930073RLKQ51TILZ35
Bio-Techne Corp
09073M104
114692.00000000
NS
USD
39756834.88000000
3.118832132128
Long
EC
CORP
US
N
1
N
N
N
Exact Sciences Corp
549300VM3X1FYD4N9Z14
Exact Sciences Corp
30063P105
689303.00000000
NS
USD
27151645.17000000
2.129984030467
Long
EC
CORP
US
N
1
N
N
N
BioNTech SE
894500UZJ5LG1F8J1U58
BioNTech SE
09075V102
277267.00000000
NS
USD
41340509.70000000
3.243067774386
Long
EC
CORP
DE
N
1
N
N
N
BioMarin Pharmaceutical Inc
NSLL8ITTRR0J5HEMR848
BioMarin Pharmaceutical Inc
09061G101
578461.00000000
NS
USD
47937063.07000000
3.760552193700
Long
EC
CORP
US
N
1
N
N
N
Illumina Inc
SQ95QG8SR5Q56LSNF682
Illumina Inc
452327109
142404.00000000
NS
USD
26253601.44000000
2.059534568139
Long
EC
CORP
US
N
1
N
N
N
Amgen Inc
62QBXGPJ34PQ72Z12S66
Amgen Inc
031162100
188972.00000000
NS
USD
45976887.60000000
3.606780942571
Long
EC
CORP
US
N
1
N
N
N
Neurocrine Biosciences Inc
549300FECER0XBN49756
Neurocrine Biosciences Inc
64125C109
483399.00000000
NS
USD
47121734.52000000
3.696591546741
Long
EC
CORP
US
N
1
N
N
N
Incyte Corp
549300Z4WN6JVZ3T4680
Incyte Corp
45337C102
586928.00000000
NS
USD
44588920.16000000
3.497898093539
Long
EC
CORP
US
N
1
N
N
N
Gilead Sciences Inc
549300WTZWR07K8MNV44
Gilead Sciences Inc
375558103
776285.00000000
NS
USD
47982175.85000000
3.764091187392
Long
EC
CORP
US
N
1
N
N
N
Agios Pharmaceuticals Inc
529900ONJHY8EOGYT555
Agios Pharmaceuticals Inc
00847X104
1719603.00000000
NS
USD
38123598.51000000
2.990708500418
Long
EC
CORP
US
N
1
N
N
N
Regeneron Pharmaceuticals Inc
549300RCBFWIRX3HYQ56
Regeneron Pharmaceuticals Inc
75886F107
65428.00000000
NS
USD
38676453.64000000
3.034078712082
Long
EC
CORP
US
N
1
N
N
N
IQVIA Holdings Inc
549300W3R20NM4KQPH86
IQVIA Holdings Inc
46266C105
201287.00000000
NS
USD
43677266.13000000
3.426380934521
Long
EC
CORP
US
N
1
N
N
N
Alnylam Pharmaceuticals Inc
529900S3ZI14OWRJII50
Alnylam Pharmaceuticals Inc
02043Q107
286729.00000000
NS
USD
41819424.65000000
3.280637549221
Long
EC
CORP
US
N
1
N
N
N
Nektar Therapeutics
5299005I24806IOIYE03
Nektar Therapeutics
640268108
7789020.00000000
NS
USD
29598276.00000000
2.321916584230
Long
EC
CORP
US
N
1
N
N
N
Biogen Inc
W8J5WZB5IY3K0NDQT671
Biogen Inc
09062X103
225918.00000000
NS
USD
46073716.92000000
3.614376979716
Long
EC
CORP
US
N
1
N
N
N
FibroGen Inc
549300Q914ULWWY95822
FibroGen Inc
31572Q808
4059234.00000000
NS
USD
42865511.04000000
3.362700617269
Long
EC
CORP
US
N
1
N
N
N
Mettler-Toledo International I
5493000BD5GJNUDIUG10
Mettler-Toledo International Inc
592688105
36564.00000000
NS
USD
42003626.28000000
3.295087742859
Long
EC
CORP
US
N
1
N
N
N
QIAGEN NV
54930036WK3GMCN17Z57
QIAGEN NV
000000000
1022988.00000000
NS
USD
48285033.60000000
3.787849680366
Long
EC
CORP
NL
N
1
N
N
N
Sarepta Therapeutics Inc
549300IKDPIED8J8IG21
Sarepta Therapeutics Inc
803607100
589238.00000000
NS
USD
44169280.48000000
3.464978327118
Long
EC
CORP
US
N
1
N
N
N
Ultragenyx Pharmaceutical Inc
529900EV44GVDN1DCX77
Ultragenyx Pharmaceutical Inc
90400D108
561911.00000000
NS
USD
33523610.26000000
2.629850016466
Long
EC
CORP
US
N
1
N
N
N
United Therapeutics Corp
5299005C4HZL4UWROC14
United Therapeutics Corp
91307C102
250165.00000000
NS
USD
58948880.60000000
4.624403917545
Long
EC
CORP
US
N
1
N
N
N
Ionis Pharmaceuticals Inc
549300SI4ZGLG0BLUZ92
Ionis Pharmaceuticals Inc
462222100
1171161.00000000
NS
USD
43356380.22000000
3.401208173916
Long
EC
CORP
US
N
1
N
N
N
Charles River Laboratories Int
549300BSQ0R4UZ5KX287
Charles River Laboratories International Inc
159864107
168573.00000000
NS
USD
36069564.81000000
2.829574287310
Long
EC
CORP
US
N
1
N
N
N
Moderna Inc
549300EI6OKH5K5Q2G38
Moderna Inc
60770K107
289806.00000000
NS
USD
41398787.10000000
3.247639502197
Long
EC
CORP
US
N
1
N
N
N
Alkermes PLC
N/A
Alkermes PLC
000000000
1634163.00000000
NS
USD
48681715.77000000
3.818968483001
Long
EC
CORP
IE
N
1
N
N
N
2022-08-18
First Trust Exchange-Traded Fund
Donald P. Swade
Donald P. Swade
Treasurer, Chief Financial Officer and Chief Accounting Officer