The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F COVER PAGE

OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8

Report for the Calendar Year or Quarter Ended: 06-30-2022
Check here if Amendment   Amendment Number:
This Amendment (Check only one.):   is a restatement.
  adds new holdings entries.
Institutional Investment Manager Filing this Report:
Name: Paradigm Biocapital Advisors LP
Address: 767 THIRD AVENUE, 17TH FLOOR
NEW YORK , NY10017
Form 13F File Number: 028-21950

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

Person Signing this Report on Behalf of Reporting Manager:
Name: David Kim
Title: Chief Operating Officer and Chief Compliance Officer
Phone: 646-970-2568
Signature, Place, and Date of Signing:
David Kim New York , X1 08-15-2022
[Signature] [City, State] [Date]
Report Type (Check only one.):
X 13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager are reported in this report.)
  13F NOTICE. (Check here if no holdings reported are in this report, and all holdings are reported by other reporting manager(s).)
  13F COMBINATION REPORT. (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)
Form 13F Summary Page
Report Summary:
Number of Other Included Managers: 0
Form 13F Information Table Entry Total: 23
Form 13F Information Table Value Total: 501,529
(thousands)
List of Other Managers Reporting for this Manager:
[If there are no entries in this list, omit this section.]
Form 13F File Number Name

List of Other Included Managers:
Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.
[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]
No. Form 13F File Number Name


SEC FORM 13F-HR

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8

COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ALPINE IMMUNE SCIENCES INC COM 02083G100 7,036 826,779 SH SOLE 826,779 0 0
ARGENX SE SPONSORED ADR 04016X101 33,651 88,816 SH SOLE 88,816 0 0
ARVINAS INC COM 04335A105 21,778 517,406 SH SOLE 517,406 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 40,175 432,170 SH SOLE 432,170 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108 17,594 1,048,516 SH SOLE 1,048,516 0 0
C4 THERAPEUTICS INC COM STK 12529R107 552 73,149 SH SOLE 73,149 0 0
ENANTA PHARMACEUTICALS INC COM 29251M106 7,006 148,216 SH SOLE 148,216 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 8,955 1,408,050 SH SOLE 1,408,050 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 46,186 1,445,566 SH SOLE 1,445,566 0 0
GRACELL BIOTECHNOLOGIES INC SPONSORED ADS 38406L103 4,309 783,445 SH SOLE 783,445 0 0
IMMUNOCORE HLDGS PLC ADS 45258D105 24,901 667,417 SH SOLE 667,417 0 0
INCYTE CORP COM 45337C102 42,243 556,043 SH SOLE 556,043 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 53,823 978,596 SH SOLE 978,596 0 0
LIQUIDIA CORPORATION COM NEW 53635D202 3,710 850,961 SH SOLE 850,961 0 0
MERUS N V COM N5749R100 10,239 452,244 SH SOLE 452,244 0 0
MIRATI THERAPEUTICS INC COM 60468T105 44,304 659,968 SH SOLE 659,968 0 0
OYSTER PT PHARMA INC COM 69242L106 5,773 1,333,330 SH SOLE 1,333,330 0 0
SIERRA ONCOLOGY INC COM NEW 82640U404 44,064 801,314 SH SOLE 801,314 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 16,857 876,156 SH SOLE 876,156 0 0
TG THERAPEUTICS INC COM 88322Q108 8,350 1,964,709 SH SOLE 1,964,709 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 38,425 163,066 SH SOLE 163,066 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104 15,117 1,306,569 SH SOLE 1,306,569 0 0
VOR BIOPHARMA INC COM 929033108 6,482 1,304,300 SH SOLE 1,304,300 0 0