The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F COVER PAGE

OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8

Report for the Calendar Year or Quarter Ended: 06-30-2022
Check here if Amendment   Amendment Number:
This Amendment (Check only one.):   is a restatement.
  adds new holdings entries.
Institutional Investment Manager Filing this Report:
Name: Plaisance Capital LLC
Address: 250 FILLMORE, SUITE 525
DENVER , CO80206
Form 13F File Number: 028-20262

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

Person Signing this Report on Behalf of Reporting Manager:
Name: Daniel R. Kozlowski
Title: Managing Member
Phone: 720-774-6201
Signature, Place, and Date of Signing:
Daniel R. Kozlowski Denver , CO 08-15-2022
[Signature] [City, State] [Date]
Report Type (Check only one.):
X 13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager are reported in this report.)
  13F NOTICE. (Check here if no holdings reported are in this report, and all holdings are reported by other reporting manager(s).)
  13F COMBINATION REPORT. (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)
Form 13F Summary Page
Report Summary:
Number of Other Included Managers: 0
Form 13F Information Table Entry Total: 25
Form 13F Information Table Value Total: 172,045
(thousands)
List of Other Managers Reporting for this Manager:
[If there are no entries in this list, omit this section.]
Form 13F File Number Name

List of Other Included Managers:
Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.
[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]
No. Form 13F File Number Name


SEC FORM 13F-HR

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8

COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ALASKA AIR GROUP INC COM 011659109 6,989 174,500 SH Call SOLE 174,500 0 0
CLARUS CORP NEW COM 18270P109 4,187 220,482 SH SOLE 220,482 0 0
CROCS INC COM 227046109 3,007 61,775 SH SOLE 61,775 0 0
CROCS INC COM 227046109 1,095 22,500 SH Call SOLE 22,500 0 0
DELTA AIR LINES INC DEL COM NEW 247361702 4,896 169,000 SH Call SOLE 169,000 0 0
INVESCO QQQ TR UNIT SER 1 46090E103 16,537 59,000 SH Put SOLE 59,000 0 0
ISHARES TR 20 YR TR BD ETF 464287432 7,053 61,400 SH SOLE 61,400 0 0
ISHARES TR RUSSELL 2000 ETF 464287655 15,242 90,000 SH Put SOLE 90,000 0 0
ISHARES TR IBOXX HI YD ETF 464288513 16,562 225,000 SH Put SOLE 225,000 0 0
KOHLS CORP COM 500255104 767 21,500 SH SOLE 21,500 0 0
KOHLS CORP COM 500255104 2,677 75,000 SH Call SOLE 75,000 0 0
NOODLES & CO COM CL A 65540B105 8,229 1,750,780 SH SOLE 1,750,780 0 0
NOODLES & CO COM CL A 65540B105 5,271 1,121,500 SH Call SOLE 1,121,500 0 0
PROSHARES TR SHORT BITCOIN 74347G291 1,549 35,300 SH SOLE 35,300 0 0
PURE CYCLE CORP COM NEW 746228303 41,620 3,948,787 SH SOLE 3,948,787 0 0
SKECHERS U S A INC CL A 830566105 2,264 63,645 SH SOLE 63,645 0 0
SKECHERS U S A INC CL A 830566105 3,302 92,800 SH Call SOLE 92,800 0 0
SMART SAND INC COM 83191H107 380 190,000 SH SOLE 190,000 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 3,018 8,000 SH Put SOLE 8,000 0 0
TESLA INC COM 88160R101 9,765 14,500 SH Put SOLE 14,500 0 0
TRIMBLE INC COM 896239100 524 9,000 SH SOLE 9,000 0 0
UNITED AIRLS HLDGS INC COM 910047109 4,144 117,000 SH Call SOLE 117,000 0 0
VANECK ETF TRUST GOLD MINERS ETF 92189F106 8,488 310,000 SH Call SOLE 310,000 0 0
WAYFAIR INC CL A 94419L101 2,570 59,000 SH Put SOLE 59,000 0 0
WINGSTOP INC COM 974155103 1,909 25,530 SH SOLE 25,530 0 0