The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F COVER PAGE
OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8
Report for the Calendar Year or Quarter Ended: 06-30-2022
Check here if Amendment   Amendment Number:
This Amendment (Check only one.):   is a restatement.
  adds new holdings entries.
Institutional Investment Manager Filing this Report:
Name: RTW INVESTMENTS, LP
Address: 40 10th Avenue
7th Floor
New York , NY10014
Form 13F File Number: 028-16670

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

Person Signing this Report on Behalf of Reporting Manager:
Name: Roderick Wong
Title: Managing Partner
Phone: 646-597-6980
Signature, Place, and Date of Signing:
/s/ Roderick Wong New York , NY 08-15-2022
[Signature] [City, State] [Date]
Report Type (Check only one.):
X 13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager are reported in this report.)
  13F NOTICE. (Check here if no holdings reported are in this report, and all holdings are reported by other reporting manager(s).)
  13F COMBINATION REPORT. (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)
Form 13F Summary Page
Report Summary:
Number of Other Included Managers: 3
Form 13F Information Table Entry Total: 107
Form 13F Information Table Value Total: 3,870,392
(thousands)
List of Other Managers Reporting for this Manager:
[If there are no entries in this list, omit this section.]
Form 13F File Number Name
028-16671 RTW MASTER FUND, LTD.
028-19525 RTW Innovation Master Fund Ltd.
028-19571 RTW Venture Fund Ltd

List of Other Included Managers:
Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.
[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]
No. Form 13F File Number Name
1 028-16671 RTW MASTER FUND, LTD.
2 028-19525 RTW Innovation Master Fund Ltd.
3 028-19571 RTW Venture Fund Ltd
SEC FORM 13F-HR

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109 43,417 959,481 SH SOLE 1,2,3 959,481 0 0
2SEVENTY BIO INC COMMON STOCK 901384107 16,230 1,229,508 SH SOLE 1,2,3 1,229,508 0 0
5 01 ACQUISITION CORP COM CL A 33836P105 3,877 392,000 SH SOLE 1,2,3 392,000 0 0
908 DEVICES INC COM 65443P102 10,562 512,957 SH SOLE 1,2,3 512,957 0 0
AADI BIOSCIENCES INC COM 00032Q104 9,421 764,701 SH SOLE 1,2,3 764,701 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 59,518 4,224,109 SH SOLE 1,2,3 4,224,109 0 0
ADICET BIO INC COM 007002108 57,689 3,951,281 SH SOLE 1,2,3 3,951,281 0 0
AGENUS INC COM NEW 00847G705 3,073 1,583,822 SH SOLE 1,2,3 1,583,822 0 0
AKOYA BIOSCIENCES INC COM 00974H104 3,001 233,557 SH SOLE 1,2,3 233,557 0 0
ALIGN TECHNOLOGY INC COM 016255101 9,940 42,000 SH SOLE 1,2,3 42,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 245,518 1,683,362 SH SOLE 1,2,3 1,683,362 0 0
APOLLO ENDOSURGERY INC COM 03767D108 942 258,064 SH SOLE 1,2,3 258,064 0 0
APYX MEDICAL CORPORATION COM 03837C106 19,914 3,398,279 SH SOLE 1,2,3 3,398,279 0 0
ARGENX SE SPONSORED ADR 04016X101 167,706 442,635 SH SOLE 1,2,3 442,635 0 0
ARYA SCIENCES ACQU CORP IV CL A G31659108 4,905 500,000 SH SOLE 1,2,3 500,000 0 0
ARYA SCIENCES ACQUISITN CORP CLASS A ORD SHS G31658100 4,860 500,000 SH SOLE 1,2,3 500,000 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 1,609 3,250,000 SH SOLE 1,2,3 3,250,000 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 14,010 5,741,939 SH SOLE 1,2,3 5,741,939 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 69,671 4,795,000 SH SOLE 1,2,3 4,795,000 0 0
AVITA MEDICAL INC COM 05380C102 507 106,667 SH SOLE 1,2,3 106,667 0 0
AXONICS INC COM 05465P101 66,869 1,179,965 SH SOLE 1,2,3 1,179,965 0 0
AXSOME THERAPEUTICS INC COM 05464T104 62,001 1,618,819 SH SOLE 1,2,3 1,618,819 0 0
BCLS ACQUISITION CORP COM CL A G0904B105 6,064 612,500 SH SOLE 1,2,3 612,500 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108 21,416 1,276,276 SH SOLE 1,2,3 1,276,276 0 0
BRAINSWAY LTD SPONSORED ADS 10501L106 7,740 1,602,381 SH SOLE 1,2,3 1,602,381 0 0
C4 THERAPEUTICS INC COM STK 12529R107 23,335 3,094,825 SH SOLE 1,2,3 3,094,825 0 0
CASTLE BIOSCIENCES INC COM 14843C105 20,058 913,789 SH SOLE 1,2,3 913,789 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 83,150 3,084,215 SH SOLE 1,2,3 3,084,215 0 0
CINCOR PHARMA INC COM 17240Y109 26,182 1,389,705 SH SOLE 1,2,3 1,389,705 0 0
CODEX DNA INC COM 192003101 180 100,000 SH SOLE 1,2,3 100,000 0 0
CODEXIS INC COM 192005106 9,628 920,448 SH SOLE 1,2,3 920,448 0 0
CRYOPORT INC COM PAR $0.001 229050307 10,388 335,299 SH SOLE 1,2,3 335,299 0 0
CTI BIOPHARMA CORP COM 12648L601 2,816 471,630 SH SOLE 1,2,3 471,630 0 0
CUTERA INC COM 232109108 66,390 1,770,400 SH SOLE 1,2,3 1,770,400 0 0
CYTEK BIOSCIENCES INC COM 23285D109 9,838 916,838 SH SOLE 1,2,3 916,838 0 0
CYTOKINETICS INC COM NEW 23282W605 100,629 2,561,182 SH SOLE 1,2,3 2,561,182 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 5,215 2,849,707 SH SOLE 1,2,3 2,849,707 0 0
DERMTECH INC COM 24984K105 17,277 3,118,666 SH SOLE 1,2,3 3,118,666 0 0
ESSA PHARMA INC COM NEW 29668H708 8,307 2,637,192 SH SOLE 1,2,3 2,637,192 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108 128,834 2,369,138 SH SOLE 1,2,3 2,369,138 0 0
EXAGEN INC COM 30068X103 5,884 1,025,002 SH SOLE 1,2,3 1,025,002 0 0
FULCRUM THERAPEUTICS INC COM 359616109 19,410 3,961,194 SH SOLE 1,2,3 3,961,194 0 0
GENETRON HLDGS LTD ADS 37186H100 2,038 1,198,961 SH SOLE 1,2,3 1,198,961 0 0
GH RESEARCH PLC ORDINARY SHARES G3855L106 21,646 2,168,957 SH SOLE 1,2,3 2,168,957 0 0
GLOBUS MED INC CL A 379577208 62,963 1,121,527 SH SOLE 1,2,3 1,121,527 0 0
GUARDANT HEALTH INC COM 40131M109 37,310 924,887 SH SOLE 1,2,3 924,887 0 0
ILLUMINA INC COM 452327109 104,048 564,375 SH SOLE 1,2,3 564,375 0 0
IMMATICS N.V SHS N44445109 3,049 350,000 SH SOLE 1,2,3 350,000 0 0
IMMUNIC INC COM 4525EP101 9,584 2,761,968 SH SOLE 1,2,3 2,761,968 0 0
IMMUNOCORE HLDGS PLC ADS 45258D105 149,097 3,996,154 SH SOLE 1,2,3 3,996,154 0 0
ISOPLEXIS CORP COM 465005106 788 365,000 SH SOLE 1,2,3 365,000 0 0
JOHNSON & JOHNSON COM 478160104 3,218 18,127 SH SOLE 1,2,3 18,127 0 0
JOUNCE THERAPEUTICS INC COM 481116101 13,206 4,358,433 SH SOLE 1,2,3 4,358,433 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 7,424 2,327,403 SH SOLE 1,2,3 2,327,403 0 0
LANDOS BIOPHARMA INC COM 515069102 3,112 4,275,722 SH SOLE 1,2,3 4,275,722 0 0
MACROGENICS INC COM 556099109 11,728 3,975,554 SH SOLE 1,2,3 3,975,554 0 0
MASIMO CORP COM 574795100 176,534 1,350,993 SH SOLE 1,2,3 1,350,993 0 0
MAXCYTE INC COM 57777K106 3,655 772,735 SH SOLE 1,2,3 772,735 0 0
MEDICUS SCIENCES ACQUISITION *W EXP 02/12/202 G5960S124 6 33,331 SH SOLE 1,2,3 33,331 0 0
MEDICUS SCIENCES ACQUISITION CL A SHS G5960S108 2,934 300,000 SH SOLE 1,2,3 300,000 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 26,538 4,315,102 SH SOLE 1,2,3 4,315,102 0 0
MINERVA SURGICAL INC COM 60343F106 390 166,000 SH SOLE 1,2,3 166,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 126,383 1,882,663 SH SOLE 1,2,3 1,882,663 0 0
MIROMATRIX MED INC COM 60471P108 1,117 280,000 SH SOLE 1,2,3 280,000 0 0
MONTE ROSA THERAPEUTICS INC COM 61225M102 11,745 1,214,572 SH SOLE 1,2,3 1,214,572 0 0
MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD 61559X104 2,625 500,000 SH SOLE 1,2,3 500,000 0 0
NATERA INC COM 632307104 75,214 2,122,283 SH SOLE 1,2,3 2,122,283 0 0
NAUTILUS BIOTECHNOLOGY INC COM 63909J108 2,959 1,100,000 SH SOLE 1,2,3 1,100,000 0 0
NYXOAH S A SHS B6S7WD106 3,173 344,911 SH SOLE 1,2,3 344,911 0 0
OLINK HLDG AB SPONSORED ADS 680710100 23,746 1,562,222 SH SOLE 1,2,3 1,562,222 0 0
OUTSET MED INC COM 690145107 13,517 909,652 SH SOLE 1,2,3 909,652 0 0
OYSTER PT PHARMA INC COM 69242L106 8,913 2,058,504 SH SOLE 1,2,3 2,058,504 0 0
PENUMBRA INC COM 70975L107 86,961 698,371 SH SOLE 1,2,3 698,371 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 62,638 4,395,677 SH SOLE 1,2,3 4,395,677 0 0
POINT BIOPHARMA GLOBAL INC COM 730541109 3,337 490,000 SH SOLE 1,2,3 490,000 0 0
PROCEPT BIOROBOTICS CORP COM 74276L105 5,268 161,138 SH SOLE 1,2,3 161,138 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108 90,043 3,189,605 SH SOLE 1,2,3 3,189,605 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 37,924 4,794,499 SH SOLE 1,2,3 4,794,499 0 0
PTC THERAPEUTICS INC COM 69366J200 202,115 5,045,307 SH SOLE 1,2,3 5,045,307 0 0
PULMONX CORP COM 745848101 10,175 691,255 SH SOLE 1,2,3 691,255 0 0
PYXIS ONCOLOGY INC COMMON STOCK 747324101 1,624 682,220 SH SOLE 1,2,3 682,220 0 0
QUANTERIX CORP COM 74766Q101 29,452 1,819,120 SH SOLE 1,2,3 1,819,120 0 0
REGENXBIO INC COM 75901B107 45,581 1,845,366 SH SOLE 1,2,3 1,845,366 0 0
RELMADA THERAPEUTICS INC COM 75955J402 50,088 2,637,581 SH SOLE 1,2,3 2,637,581 0 0
RENOVACOR INC *W EXP 99/99/999 75989E114 21 350,000 SH SOLE 1,2,3 350,000 0 0
RENOVACOR INC COM 75989E106 6,085 3,000,803 SH SOLE 1,2,3 3,000,803 0 0
RESEARCH ALLIANCE CORP II COM CL A 760873109 6,223 637,000 SH SOLE 1,2,3 637,000 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 217,447 15,802,802 SH SOLE 1,2,3 15,802,802 0 0
ROIVANT SCIENCES LTD SHS G76279101 3,267 802,717 SH SOLE 1,2,3 802,717 0 0
RXSIGHT INC COM 78349D107 2,112 150,000 SH SOLE 1,2,3 150,000 0 0
SCIENCE 37 HOLDINGS INC COM 808644108 8,618 4,287,546 SH SOLE 1,2,3 4,287,546 0 0
SIGHT SCIENCES INC COM 82657M105 8,964 997,099 SH SOLE 1,2,3 997,099 0 0
SINGULAR GENOMICS SYSTEMS IN COM 82933R100 382 100,000 SH SOLE 1,2,3 100,000 0 0
SOMALOGIC INC CLASS A COM 83444K105 9,559 2,114,830 SH SOLE 1,2,3 2,114,830 0 0
STOKE THERAPEUTICS INC COM 86150R107 48,241 3,651,823 SH SOLE 1,2,3 3,651,823 0 0
SUMMIT HEALTHCRE ACQUISTN CO UNIT 06/03/2026 G8566R128 4,875 500,000 SH SOLE 1,2,3 500,000 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 54,610 922,630 SH SOLE 1,2,3 922,630 0 0
TARSUS PHARMACEUTICALS INC COM 87650L103 29,399 2,013,601 SH SOLE 1,2,3 2,013,601 0 0
TELA BIO INC COM 872381108 7,133 1,017,546 SH SOLE 1,2,3 1,017,546 0 0
TENAYA THERAPEUTICS INC COM 87990A106 13,843 2,458,750 SH SOLE 1,2,3 2,458,750 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 236,598 435,500 SH SOLE 1,2,3 435,500 0 0
TWIST BIOSCIENCE CORP COM 90184D100 9,439 270,000 SH SOLE 1,2,3 270,000 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 81,930 1,373,284 SH SOLE 1,2,3 1,373,284 0 0
UROGEN PHARMA LTD COM M96088105 7,023 857,464 SH SOLE 1,2,3 857,464 0 0
VENTYX BIOSCIENCES INC COM 92332V107 18,978 1,551,778 SH SOLE 1,2,3 1,551,778 0 0
VERICEL CORP COM 92346J108 88,707 3,522,904 SH SOLE 1,2,3 3,522,904 0 0
VERU INC COM 92536C103 25,097 2,220,983 SH SOLE 1,2,3 2,220,983 0 0