The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F COVER PAGE

OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8

Report for the Calendar Year or Quarter Ended: 06-30-2022
Check here if Amendment   Amendment Number:
This Amendment (Check only one.):   is a restatement.
  adds new holdings entries.
Institutional Investment Manager Filing this Report:
Name: ARCH Venture Management, LLC
Address: C/O ARCH VENTURE PARTNERS
8755 W. HIGGINS RD. #1025
CHICAGO , IL60631
Form 13F File Number: 028-19358

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

Person Signing this Report on Behalf of Reporting Manager:
Name: Mark McDonnell
Title: Managing Director, CFO and CAO
Phone: 773-380-6600
Signature, Place, and Date of Signing:
/s/ Mark McDonnell Chicago , IL 08-15-2022
[Signature] [City, State] [Date]
Report Type (Check only one.):
X 13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager are reported in this report.)
  13F NOTICE. (Check here if no holdings reported are in this report, and all holdings are reported by other reporting manager(s).)
  13F COMBINATION REPORT. (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)
Form 13F Summary Page
Report Summary:
Number of Other Included Managers: 0
Form 13F Information Table Entry Total: 10
Form 13F Information Table Value Total: 820,637
(thousands)
List of Other Managers Reporting for this Manager:
[If there are no entries in this list, omit this section.]
Form 13F File Number Name

List of Other Included Managers:
Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.
[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]
No. Form 13F File Number Name


SEC FORM 13F-HR

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8

COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
DENALI THERAPEUTICS, INC. COM 24823R105 152,116 5,168,749 SH SOLE 0 0 5,168,749
METACRINE, INC. COM 59101E103 1,470 2,940,503 SH SOLE 0 0 2,940,503
ZYMERGEN INC. COM 98985X100 147 119,205 SH SOLE 0 0 119,205
KARUNA THERAPEUTICS, INC. COM 48576A100 368,507 2,912,872 SH SOLE 0 0 2,912,872
RUBIUS THERAPEUTICS, INC. COM 78116T103 298 349,908 SH SOLE 0 0 349,908
SINGULAR GENOMICS SYSTEMS, INC. COM 82933R100 14,512 3,798,926 SH SOLE 0 0 3,798,926
EQRX, INC. COM 26886C107 170,413 36,335,375 SH SOLE 0 0 36,335,375
ERASCA, INC. COM 29479A108 61,579 11,055,554 SH SOLE 0 0 11,055,554
VERVE THERAPEUTICS, INC. COM 92539P101 38,335 2,508,809 SH SOLE 0 0 2,508,809
REVOLUTION HEALTHCARE ACQUISITION CORP. COM 76155Y108 13,260 1,357,237 SH SOLE 0 0 1,357,237