The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F COVER PAGE
OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8
Report for the Calendar Year or Quarter Ended: 06-30-2022
Check here if Amendment   Amendment Number:
This Amendment (Check only one.):   is a restatement.
  adds new holdings entries.
Institutional Investment Manager Filing this Report:
Name: Nantahala Capital Management, LLC
Address: 130 Main St.
2nd Floor
New Canaan , CT06840
Form 13F File Number: 028-14750

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

Person Signing this Report on Behalf of Reporting Manager:
Name: Taki Vasilakis
Title: Chief Compliance Officer
Phone: 203-308-4440
Signature, Place, and Date of Signing:
/s/ Taki Vasilakis New Canaan , CT 08-15-2022
[Signature] [City, State] [Date]
Report Type (Check only one.):
X 13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager are reported in this report.)
  13F NOTICE. (Check here if no holdings reported are in this report, and all holdings are reported by other reporting manager(s).)
  13F COMBINATION REPORT. (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)
Form 13F Summary Page
Report Summary:
Number of Other Included Managers: 0
Form 13F Information Table Entry Total: 124
Form 13F Information Table Value Total: 1,994,187
(thousands)
List of Other Managers Reporting for this Manager:
[If there are no entries in this list, omit this section.]
Form 13F File Number Name

List of Other Included Managers:
Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.
[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]
No. Form 13F File Number Name
SEC FORM 13F-HR

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
5 01 ACQUISITION CORP COM CL A 33836P105 1,554 157,044 SH SOLE 157,044 0 0
ACER THERAPEUTICS INC COM 00444P108 934 741,010 SH SOLE 741,010 0 0
ADTALEM GLOBAL ED INC COM 00737L103 32,373 900,000 SH Put SOLE 900,000 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 1,958 3,877,311 SH SOLE 3,877,311 0 0
AKUMIN INC COM 01021F109 3,325 5,545,233 SH SOLE 5,545,233 0 0
ALECTOR INC COM 014442107 937 92,176 SH SOLE 92,176 0 0
ALTA EQUIPMENT GROUP INC COMMON STOCK 02128L106 15,003 1,672,545 SH SOLE 1,672,545 0 0
AMPHASTAR PHARMACEUTICALS IN COM 03209R103 34,790 1,000,000 SH Put SOLE 1,000,000 0 0
AMRYT PHARMA PLC SPONSORED ADS 03217L106 10,922 1,562,458 SH SOLE 1,562,458 0 0
ANGION BIOMEDICA CORP COM 03476J107 1,289 1,131,001 SH SOLE 1,131,001 0 0
APOLLO ENDOSURGERY INC COM 03767D108 13,589 3,723,010 SH SOLE 3,723,010 0 0
APOLLO ENDOSURGERY INC COM 03767D108 5,840 1,600,000 SH Call SOLE 1,600,000 0 0
APTOSE BIOSCIENCES INC COM NEW 03835T200 5,367 7,232,676 SH SOLE 7,232,676 0 0
ARYA SCIENCES ACQU CORP IV CL A G31659108 3,168 322,929 SH SOLE 322,929 0 0
ARYA SCIENCES ACQUISITN CORP CLASS A ORD SHS G31658100 8,384 862,566 SH SOLE 862,566 0 0
AURA BIOSCIENCES INC COM 05153U107 4,863 343,215 SH SOLE 343,215 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 14,554 5,142,855 SH SOLE 5,142,855 0 0
AVALO THERAPEUTICS INC COM 05338F108 3,355 6,710,327 SH SOLE 6,710,327 0 0
B RILEY PRINCIPAL 150 MERGER *W EXP 03/01/202 05601V111 69 185,653 SH SOLE 185,653 0 0
B RILEY PRINCIPAL 150 MERGER COM CL A 05601V103 2,965 297,727 SH SOLE 297,727 0 0
B. RILEY FINANCIAL INC COM 05580M108 3,257 77,083 SH SOLE 77,083 0 0
BBQ HLDGS INC COM 05551A109 9,881 948,254 SH SOLE 948,254 0 0
CATALYST BIOSCIENCES INC COM NEW 14888D208 4,906 2,755,903 SH SOLE 2,755,903 0 0
CIDARA THERAPEUTICS INC COM 171757107 2,355 4,819,090 SH SOLE 4,819,090 0 0
CODEXIS INC COM 192005106 43,096 4,120,098 SH SOLE 4,120,098 0 0
CODEXIS INC COM 192005106 523 50,000 SH Call SOLE 50,000 0 0
COGNITION THERAPEUTICS INC COM 19243B102 407 192,752 SH SOLE 192,752 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 6,988 1,659,840 SH SOLE 1,659,840 0 0
COSTCO WHSL CORP NEW COM 22160K105 34,266 71,495 SH SOLE 71,495 0 0
COSTCO WHSL CORP NEW COM 22160K105 47,928 100,000 SH Put SOLE 100,000 0 0
CUE BIOPHARMA INC COM 22978P106 250 100,464 SH SOLE 100,464 0 0
CURIS INC COM NEW 231269200 3,572 3,628,162 SH SOLE 3,628,162 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 7,801 2,644,306 SH SOLE 2,644,306 0 0
DARDEN RESTAURANTS INC COM 237194105 22,624 200,000 SH Put SOLE 200,000 0 0
DARIOHEALTH CORP COM NEW 23725P209 10,627 1,730,810 SH SOLE 1,730,810 0 0
DHI GROUP INC COM 23331S100 20,568 4,138,483 SH SOLE 4,138,483 0 0
DXP ENTERPRISES INC COM NEW 233377407 36,910 1,205,031 SH SOLE 1,205,031 0 0
EARGO INC COM 270087109 774 1,028,965 SH SOLE 1,028,965 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108 109,162 2,007,385 SH SOLE 2,007,385 0 0
EXAGEN INC COM 30068X103 896 156,135 SH SOLE 156,135 0 0
FARADAY FUTRE INTLGT ELCTR I COM 307359109 910 350,000 SH SOLE 350,000 0 0
FINTECH ACQUISITION CORP V *W EXP 12/31/202 31810Q115 30 333,331 SH SOLE 333,331 0 0
FINTECH ACQUISITION CORP VI *W EXP 03/31/202 31811H114 39 240,600 SH SOLE 240,600 0 0
FORTRESS BIOTECH INC COM 34960Q109 7,356 8,758,648 SH SOLE 8,758,648 0 0
FTAC HERA ACQUISITION CORP *W EXP 02/28/202 G3728Y111 53 222,949 SH SOLE 222,949 0 0
FTAC HERA ACQUISITION CORP CLASS A ORD SHS G3728Y103 7,714 787,130 SH SOLE 787,130 0 0
GOGO INC COM 38046C109 8,095 500,000 SH Put SOLE 500,000 0 0
GOLDEN ENTMT INC COM 381013101 19,181 484,974 SH SOLE 484,974 0 0
GUARDFORCE AI CO LTD *W EXP 10/01/202 G4236L120 19 154,205 SH SOLE 154,205 0 0
HELIOGEN INC COMMON STOCK 42329E105 916 433,909 SH SOLE 433,909 0 0
HERBALIFE NUTRITION LTD COM SHS G4412G101 17,744 867,700 SH Call SOLE 867,700 0 0
HYPERFINE INC COM CL A 44916K106 1,215 544,930 SH SOLE 544,930 0 0
IDW MEDIA HLDGS INC CL B 44951N106 1,411 1,052,852 SH SOLE 1,052,852 0 0
IMAC HLDGS INC COM 44967K104 1,044 1,259,379 SH SOLE 1,259,379 0 0
IMAX CORP COM 45245E109 46,100 2,729,441 SH SOLE 2,729,441 0 0
IMAX CORP COM 45245E109 37,011 2,191,300 SH Call SOLE 2,191,300 0 0
IMMATICS N.V *W EXP 07/01/202 N44445117 2,113 1,035,613 SH SOLE 1,035,613 0 0
IMMATICS N.V SHS N44445109 27,191 3,121,759 SH SOLE 3,121,759 0 0
IMV INC COM 44974L103 933 1,424,676 SH SOLE 1,424,676 0 0
IN8BIO INC COM 45674E109 359 148,801 SH SOLE 148,801 0 0
INMODE LTD SHS M5425M103 3,544 158,154 SH SOLE 158,154 0 0
INSU ACQUISITION CORP III *W EXP 12/31/202 457817112 30 333,332 SH SOLE 333,332 0 0
INSU ACQUISITION CORP III COM CL A 457817104 9,655 980,183 SH SOLE 980,183 0 0
ISHARES TR RUSSELL 2000 ETF 464287655 4,043 23,873 SH SOLE 23,873 0 0
ISHARES TR RUSSELL 2000 ETF 464287655 423,400 2,500,000 SH Put SOLE 2,500,000 0 0
KEROS THERAPEUTICS INC COM 492327101 25,196 911,901 SH SOLE 911,901 0 0
KEROS THERAPEUTICS INC COM 492327101 1,158 41,900 SH Call SOLE 41,900 0 0
KINTARA THERAPEUTICS INC COM 49720K101 32 116,234 SH SOLE 116,234 0 0
KROGER CO COM 501044101 2,366 50,000 SH Call SOLE 50,000 0 0
LAVA THERAPEUTICS NV SHS N51517105 953 322,980 SH SOLE 322,980 0 0
LIGHT & WONDER INC COM 80874P109 52,222 1,111,338 SH SOLE 1,111,338 0 0
LILLY ELI & CO COM 532457108 113,480 350,000 SH Put SOLE 350,000 0 0
LUCID DIAGNOSTICS INC COM 54948X109 698 308,978 SH SOLE 308,978 0 0
LUXFER HOLDINGS PLC SHS G5698W116 35,196 2,327,801 SH SOLE 2,327,801 0 0
LYRA THERAPEUTICS INC COM 55234L105 13,389 2,369,668 SH SOLE 2,369,668 0 0
MEDIAALPHA INC CL A 58450V104 16,160 1,640,624 SH SOLE 1,640,624 0 0
MERRIMACK PHARMACEUTICALS IN COM NEW 590328209 2,924 491,509 SH SOLE 491,509 0 0
META FINL GROUP INC COM 59100U108 38,108 985,459 SH SOLE 985,459 0 0
METROMILE INC *W EXP 02/09/202 591697115 57 507,460 SH SOLE 507,460 0 0
METROMILE INC COM 591697107 298 325,002 SH SOLE 325,002 0 0
MILLERKNOLL INC COM 600544100 44,862 1,707,739 SH SOLE 1,707,739 0 0
NAUTILUS BIOTECHNOLOGY INC COM 63909J108 2,111 784,798 SH SOLE 784,798 0 0
NEURONETICS INC COM 64131A105 2,463 767,400 SH SOLE 767,400 0 0
NEUROPACE INC COM 641288105 2,368 478,438 SH SOLE 478,438 0 0
ON24 INC COM 68339B104 5,413 570,403 SH SOLE 570,403 0 0
PAR TECHNOLOGY CORP NOTE 2.875% 4/1 698884AC7 6,675 5,785,000 PRN SOLE 5,785,000 0 0
PAYA HOLDINGS INC COM CL A 70434P103 19,445 2,959,599 SH SOLE 2,959,599 0 0
PAYONEER GLOBAL INC COM 70451X104 1,511 385,366 SH SOLE 385,366 0 0
PELOTON INTERACTIVE INC CL A COM 70614W100 22,481 2,448,878 SH SOLE 2,448,878 0 0
PELOTON INTERACTIVE INC CL A COM 70614W100 10,452 1,138,600 SH Call SOLE 1,138,600 0 0
PERDOCEO ED CORP COM 71363P106 5,890 500,000 SH Put SOLE 500,000 0 0
PERELLA WEINBERG PARTNERS *W EXP 12/31/202 71367G110 264 409,128 SH SOLE 409,128 0 0
PERELLA WEINBERG PARTNERS CLASS A COM 71367G102 2,931 502,676 SH SOLE 502,676 0 0
QUALTEK SERVICES INC *W EXP 02/14/202 74760R113 15 96,244 SH SOLE 96,244 0 0
RAFAEL HLDGS INC COM CL B 75062E106 36 19,435 SH SOLE 19,435 0 0
READING INTL INC CL A 755408101 11,578 3,207,247 SH SOLE 3,207,247 0 0
RED VIOLET INC COM 75704L104 24,595 1,291,771 SH SOLE 1,291,771 0 0
RH COM 74967X103 19,103 90,000 SH SOLE 90,000 0 0
RINGCENTRAL INC CL A 76680R206 7,839 150,000 SH SOLE 150,000 0 0
RMR GROUP INC CL A 74967R106 27,517 970,623 SH SOLE 970,623 0 0
RUMBLEON INC COM CL B 781386305 2,942 200,000 SH SOLE 200,000 0 0
SCULLY ROYALTY LTD COM SHS G7T96K107 6,189 771,196 SH SOLE 771,196 0 0
SEMLER SCIENTIFIC INC COM 81684M104 9,767 346,606 SH SOLE 346,606 0 0
SHIFT TECHNOLOGIES INC CL A 82452T107 1,792 2,662,933 SH SOLE 2,662,933 0 0
SILVERBACK THERAPEUTICS INC COM 82835W108 5,877 1,386,138 SH SOLE 1,386,138 0 0
SITIO ROYALTIES CORP *W EXP 08/23/202 82982V119 93 582,350 SH SOLE 582,350 0 0
SOLENO THERAPEUTICS INC COM NEW 834203200 1,675 9,436,512 SH SOLE 9,436,512 0 0
STRATA SKIN SCIENCES INC COM NEW 86272A206 4,397 4,575,812 SH SOLE 4,575,812 0 0
STRYKER CORPORATION COM 863667101 4,575 23,000 SH SOLE 23,000 0 0
STRYKER CORPORATION COM 863667101 23,872 120,000 SH Put SOLE 120,000 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 51,238 2,663,087 SH SOLE 2,663,087 0 0
TAYSHA GENE THERAPIES INC COM SHS 877619106 6,114 1,643,438 SH SOLE 1,643,438 0 0
TC BIOPHARM HOLDINGS PLC *W EXP 02/08/202 87807D111 56 235,294 SH SOLE 235,294 0 0
TRANSACT TECHNOLOGIES INC COM 892918103 279 69,991 SH SOLE 69,991 0 0
TRAVEL PLUS LEISURE CO COM 894164102 37,860 975,281 SH SOLE 975,281 0 0
TRAVEL PLUS LEISURE CO COM 894164102 35,679 919,100 SH Call SOLE 919,100 0 0
TRAVELCENTERS OF AMERICA INC COM NEW 89421B109 43,865 1,272,570 SH SOLE 1,272,570 0 0
UNICYCIVE THERAPEUTICS INC COM 90466Y103 606 729,680 SH SOLE 729,680 0 0
UNIQURE NV SHS N90064101 57,612 3,090,757 SH SOLE 3,090,757 0 0
UNIQURE NV SHS N90064101 14,912 800,000 SH Call SOLE 800,000 0 0
VIEMED HEALTHCARE INC COM 92663R105 9,226 1,714,926 SH SOLE 1,714,926 0 0
VROOM INC COM 92918V109 1,875 1,500,000 SH Call SOLE 1,500,000 0 0
WEJO GROUP LIMITED COMMON SHARES G9525W109 158 132,728 SH SOLE 132,728 0 0
ZOVIO INC COM 98979V102 1,606 1,655,335 SH SOLE 1,655,335 0 0