FORM 3 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
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1. Name and Address of Reporting Person *
Jacob Jeffrey E.
(Last) (First) (Middle)
712 VISTA BLVD #305
(Street)
WACONIA MN 55387
(City) (State) (Zip)
2. Date of Event Requiring Statement (Month/Day/Year)
06/15/2022 		3. Issuer Name and Ticker or Trading Symbol
Panbela Therapeutics, Inc. [ PBLA ]
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
X Director 10% Owner
Officer (give title below) Other (specify below)
5. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
X Form filed by One Reporting Person
Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4) 2. Amount of Securities Beneficially Owned (Instr. 4) 3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock 261,931
D
 
Common Stock 17,771
I
Jointly with spouse
Common Stock 54,374
I
By trust
Table II - Derivative Securities Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4) 2. Date Exercisable and Expiration Date (Month/Day/Year) 3. Title and Amount of Securities Underlying Derivative Security (Instr. 4) 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 6. Nature of Indirect Beneficial Ownership (Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (right to buy)   (1) 09/26/2022 Common Stock 41,766 1.24 D  
Stock Option (right to buy)   (1) 09/26/2022 Common Stock 35,543 1.47 D  
Stock Option (right to buy)   (1) 12/28/2030 Common Stock 91,523 0.22 D  
Stock Option (right to buy)   (1) 12/28/2030 Common Stock 177,715 0.22 D  
Warrants (right to buy)   (1) 02/01/2023 Common Stock 5,174 5.63 I By trust
Explanation of Responses:
1. Fully vested.
Remarks:
Exhibit List: Power for Attorney EX-24
/s/ Joshua L. Colburn, Attorney-in-Fact 06/25/2022
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
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POWER OF ATTORNEY
EX-24

 I, Jeffrey E. Jacob hereby authorize and designate each of Jennifer K.
 Simpson, Susan Horvath, W. Morgan Burns, Joshua L. Colburn, Vilena Nicolet, and
 Amra Hoso signing singly, as my true and lawful attorney-in-fact to:

 (1)	execute for and on my behalf, in my capacity as an officer and/or
 director of Panbela Therapeutics, Inc. (the "Company"), Form ID or Forms 3, 4
 and 5 in accordance with Section 16(a) of the Securities Exchange Act of 1934
 (the "Exchange Act") and the rules and regulations promulgated thereunder and
 other forms or reports on my behalf as may be required to be filed in
 connection with my ownership, acquisition, or disposition of securities
 of the Company, including Form 144 and Schedule 13D or Schedule 13G;

 (2)	do and perform any and all acts for and on my behalf, which may be
 necessary or desirable to complete and execute any such Form ID, Forms 3, 4 or
 5, Form 144, Schedule 13D or Schedule 13G and timely file such form with the
 Securities and Exchange Commission and any stock exchange or similar authority;
 and

 (3)	take any other action of any type whatsoever in connection with the
 foregoing which, in the opinion of such attorney-in-fact, may be to my benefit,
 in my best interest, or legally required of me, it being understood that the
 statements executed by such attorney-in-fact on my behalf pursuant to this
 Power of Attorney shall be in such form and shall contain such terms
 and conditions as such attorney-in-fact may approve in such
 attorney-in-fact's discretion.

 I hereby further grant to each such attorney-in-fact full power and
 authority to do and perform any and every act and thing whatsoever requisite,
 necessary, or proper to be done in the exercise of any of the rights and
 powers herein granted, as fully to all intents and purposes as I might or
 could do if personally present, with full power of substitution or
 revocation, hereby ratifying and confirming all that such
 attorney-in-fact, or such attorney-in-fact's substitute or substitutes,
 shall lawfully do or cause to be done by virtue of this Power of
 Attorney and the rights and powers herein granted. I herebyz
 acknowledge that the foregoing attorneys-in-fact, in serving in such
 capacity at my request, are not assuming, nor is the Company assuming,
 any of my responsibilities to comply with Section 16 of the Exchange Act.

 This Power of Attorney shall remain in full force and effect until I am no
 longer required to file Form ID or Forms 3, 4 and 5 with respect to my
 holdings of and transactions in securities issued by the Company, unless
 earlier revoked by me in a signed writing delivered to the foregoing
 attorneys-in-fact.  Notwithstanding the foregoing, if any such
 attorney-in-fact hereafter ceases to be at least one of the following:
  (i) a partner of Faegre Drinker Biddle & Reath LLP or
 (ii) an employee of Faegre Drinker Biddle & Reath LLP, then this
 Power of Attorney shall be automatically revoked solely as to
 such individual, immediately upon such cessation, without
 any further action on my part.

 I hereby revoke all previous Powers of Attorney that have been granted
 by me in connection with my reporting obligations under Section 16 of
 the Exchange Act with respect to my holdings of and transactions
 in securities issued by the Company.

 IN WITNESS WHEREOF, I have caused this Power of Attorney to be duly
 executed as of this 15th day of June 2022.

/s/ Jeffrey E. Jacob