The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F COVER PAGE
OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8
Report for the Calendar Year or Quarter Ended: 03-31-2022
Check here if Amendment   Amendment Number:
This Amendment (Check only one.):   is a restatement.
  adds new holdings entries.
Institutional Investment Manager Filing this Report:
Name: ARMISTICE CAPITAL, LLC
Address: 510 MADISON AVENUE, 7TH FLOOR
NEW YORK , NY10022
Form 13F File Number: 028-16738

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

Person Signing this Report on Behalf of Reporting Manager:
Name: Anthony Cordone
Title: Chief Financial Officer
Phone: 212.231.4930
Signature, Place, and Date of Signing:
/s/ Anthony Cordone New York , NY 05-16-2022
[Signature] [City, State] [Date]
Report Type (Check only one.):
X 13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager are reported in this report.)
  13F NOTICE. (Check here if no holdings reported are in this report, and all holdings are reported by other reporting manager(s).)
  13F COMBINATION REPORT. (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)
Form 13F Summary Page
Report Summary:
Number of Other Included Managers: 0
Form 13F Information Table Entry Total: 141
Form 13F Information Table Value Total: 5,171,408
(thousands)
List of Other Managers Reporting for this Manager:
[If there are no entries in this list, omit this section.]
Form 13F File Number Name

List of Other Included Managers:
Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.
[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]
No. Form 13F File Number Name
SEC FORM 13F-HR

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2SEVENTY BIO INC COMMON STOCK 901384107 34,120 2,000,000 SH SOLE 2,000,000 0 0
ADAPTHEALTH CORP COMMON STOCK 00653Q102 8,015 500,000 SH SOLE 500,000 0 0
ADDEX THERAPEUTICS LTD SPONSORED ADS 00654J107 2,886 568,088 SH SOLE 568,088 0 0
ADIAL PHARMACEUTICALS INC COM 00688A106 3,653 1,817,454 SH SOLE 1,817,454 0 0
ADOBE SYSTEMS INCORPORATED COM 00724F101 36,450 80,000 SH SOLE 80,000 0 0
ADVANCED MICRO DEVICES INC COM 007903107 8,966 82,000 SH SOLE 82,000 0 0
ADVANTAGE SOLUTIONS INC COM CL A 00791N102 15,312 2,400,000 SH SOLE 2,400,000 0 0
AGILE THERAPEUTICS INC COM 00847L100 953 4,547,100 SH SOLE 4,547,100 0 0
AGRIFORCE GROWING SYSTEMS LT *W EXP 02/01/202 C00948114 354 600,000 SH SOLE 600,000 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 19,584 180,000 SH SOLE 180,000 0 0
ALKERMES PLC SHS G01767105 47,989 1,824,000 SH SOLE 1,824,000 0 0
ALPHABET INC CAP STK CL A 02079K305 41,720 15,000 SH SOLE 15,000 0 0
ALPHATEC HLDGS INC COM NEW 02081G201 23,414 2,036,000 SH SOLE 2,036,000 0 0
AMERICAN REBEL HOLDINGS INC *W EXP 01/20/202 02919L117 169 481,927 SH SOLE 481,927 0 0
AMRYT PHARMA PLC SPONSORED ADS 03217L106 8,270 1,000,000 SH SOLE 1,000,000 0 0
ANHEUSER BUSCH INBEV SA/NV SPONSORED ADR 03524A108 58,739 978,000 SH SOLE 978,000 0 0
APPLIED DNA SCIENCES INC COM 03815U300 984 459,769 SH SOLE 459,769 0 0
APPTECH PMTS CORP *W EXP 12/17/202 03834B127 179 715,000 SH SOLE 715,000 0 0
ARAVIVE INC COM 03890D108 1,805 934,975 SH SOLE 934,975 0 0
ARGENX SE SPONSORED ADR 04016X101 63,062 200,000 SH SOLE 200,000 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 4,120 2,000,000 SH SOLE 2,000,000 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 39,273 592,000 SH SOLE 592,000 0 0
ATERIAN INC COM 02156U101 12,718 5,233,572 SH SOLE 5,233,572 0 0
AUTOZONE INC COM 053332102 45,964 22,481 SH SOLE 22,481 0 0
AVALO THERAPEUTICS INC COM 05338F108 34,478 47,576,000 SH SOLE 47,576,000 0 0
AYTU BIOPHARMA INC COM NEW 054754874 2,570 2,379,936 SH SOLE 2,379,936 0 0
BEST BUY INC COM 086516101 18,180 200,000 SH SOLE 200,000 0 0
BIOGEN INC COM 09062X103 120,463 572,000 SH SOLE 572,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 62,131 524,000 SH SOLE 524,000 0 0
BIONTECH SE SPONSORED ADS 09075V102 12,792 75,000 SH SOLE 75,000 0 0
BOLT BIOTHERAPEUTICS INC COM 097702104 1,096 400,000 SH SOLE 400,000 0 0
BOSTON BEER INC CL A 100557107 10,489 27,000 SH SOLE 27,000 0 0
BRIACELL THERAPEUTICS CORP *W EXP 02/24/202 10778Y112 1,950 375,000 SH SOLE 375,000 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 101,950 1,396,000 SH SOLE 1,396,000 0 0
BROOKLYN IMMUNOTHERAPEUTICS COM 114082100 11,275 5,500,000 SH SOLE 5,500,000 0 0
CALYXT INC COM 13173L107 2,375 2,283,220 SH SOLE 2,283,220 0 0
CATALYST PHARMACEUTICALS INC COM 14888U101 69,404 8,372,000 SH SOLE 8,372,000 0 0
CEA INDUSTRIES INC *W EXP 02/11/202 86887P119 469 700,000 SH SOLE 700,000 0 0
CENTRAL GARDEN & PET CO CL A NON-VTG 153527205 62,638 1,536,000 SH SOLE 1,536,000 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 12,368 756,000 SH SOLE 756,000 0 0
CINGULATE INC *W EXP 12/03/202 17248W113 164 410,000 SH SOLE 410,000 0 0
COLGATE PALMOLIVE CO COM 194162103 48,228 636,000 SH SOLE 636,000 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 64,276 1,024,000 SH SOLE 1,024,000 0 0
CYREN LTD SHS NEW M26895132 139 27,615 SH SOLE 27,615 0 0
DATADOG INC CL A COM 23804L103 8,482 56,000 SH SOLE 56,000 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 54,100 5,836,000 SH SOLE 5,836,000 0 0
DECKERS OUTDOOR CORP COM 243537107 25,927 94,702 SH SOLE 94,702 0 0
DERMATA THERAPEUTICS INC *W EXP 08/13/202 249845116 52 325,000 SH SOLE 325,000 0 0
DIGITAL BRANDS GROUP INC *W EXP 05/01/202 25401N119 362 722,890 SH SOLE 722,890 0 0
DIRECT DIGITAL HOLDINGS INC *W EXP 02/15/202 25461T113 648 900,000 SH SOLE 900,000 0 0
DYNATRACE INC COM NEW 268150109 9,985 212,000 SH SOLE 212,000 0 0
EAGLE PHARMACEUTICALS INC COM 269796108 11,086 224,000 SH SOLE 224,000 0 0
EDESA BIOTECH INC COM 27966L108 4,326 1,456,591 SH SOLE 1,456,591 0 0
ENANTA PHARMACEUTICALS INC COM 29251M106 80,006 1,124,000 SH SOLE 1,124,000 0 0
ENERGIZER HLDGS INC NEW COM 29272W109 35,312 1,148,000 SH SOLE 1,148,000 0 0
ERYTECH PHARMA SPONSORED ADR 29604W108 3,402 1,944,075 SH SOLE 1,944,075 0 0
ESPORTS ENTMT GROUP INC *W EXP 03/02/202 29667K132 729 2,700,000 SH SOLE 2,700,000 0 0
EYENOVIA INC COM 30234E104 7,005 2,296,621 SH SOLE 2,296,621 0 0
FGI INDUSTRIES LTD *W EXP 01/21/202 G3302D111 616 933,333 SH SOLE 933,333 0 0
FIVE BELOW INC COM 33829M101 57,290 361,745 SH SOLE 361,745 0 0
FORMA THERAPEUTICS HLDGS INC SHS 34633R104 29,760 3,200,000 SH SOLE 3,200,000 0 0
FRESHPET INC COM 358039105 20,528 200,000 SH SOLE 200,000 0 0
FRONTDOOR INC COM 35905A109 20,656 692,000 SH SOLE 692,000 0 0
G MED INNOVATIONS HLDGS LTD *W EXP 06/30/202 G39462117 500 1,000,000 SH SOLE 1,000,000 0 0
GEOVAX LABS INC COM 373678507 500 435,150 SH SOLE 435,150 0 0
GOLD ROYALTY CORP *W EXP 99/99/999 38071H114 354 448,000 SH SOLE 448,000 0 0
GROM SOCIAL ENTERPRISES INC *W EXP 06/17/202 39878L118 145 723,000 SH SOLE 723,000 0 0
HEARTBEAM INC *W EXP 10/31/202 42238H116 185 500,000 SH SOLE 500,000 0 0
HOME DEPOT INC COM 437076102 104,735 349,897 SH SOLE 349,897 0 0
HTG MOLECULAR DIAGNOSTICS IN COM NEW 40434H203 1,159 834,054 SH SOLE 834,054 0 0
ILLUMINA INC COM 452327109 62,193 178,000 SH SOLE 178,000 0 0
IMMUNOCORE HLDGS PLC ADS 45258D105 5,382 180,000 SH SOLE 180,000 0 0
INCYTE CORP COM 45337C102 121,036 1,524,000 SH SOLE 1,524,000 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 15,084 50,000 SH SOLE 50,000 0 0
ISHARES TR RUSSELL 2000 ETF 464287655 574,756 28,000 SH Put SOLE 28,000 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 73,476 472,000 SH SOLE 472,000 0 0
JPMORGAN CHASE & CO COM 46625H100 20,448 150,000 SH SOLE 150,000 0 0
KRAFT HEINZ CO COM 500754106 61,921 1,572,000 SH SOLE 1,572,000 0 0
LOCAFY LIMITED *W EXP 03/23/202 Q56120118 134 242,425 SH SOLE 242,425 0 0
MACROGENICS INC COM 556099109 44,050 5,000,000 SH SOLE 5,000,000 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 95,961 978,000 SH SOLE 978,000 0 0
MARIS TECH LTD *W EXP 02/04/202 M68057112 372 1,261,058 SH SOLE 1,261,058 0 0
MEDIGUS LTD *W EXP 07/23/202 58471G128 386 1,285,715 SH SOLE 1,285,715 0 0
MEDTRONIC PLC SHS G5960L103 51,925 468,000 SH SOLE 468,000 0 0
META PLATFORMS INC CL A 30303M102 22,236 100,000 SH SOLE 100,000 0 0
MICROSOFT CORP COM 594918104 36,997 120,000 SH SOLE 120,000 0 0
MINERVA NEUROSCIENCES INC COM 603380106 850 1,024,000 SH SOLE 1,024,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 112,148 1,364,000 SH SOLE 1,364,000 0 0
MONDELEZ INTL INC CL A 609207105 25,112 400,000 SH SOLE 400,000 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 60,938 650,000 SH SOLE 650,000 0 0
NEXGEL INC *W EXP 12/01/202 65344E115 245 550,000 SH SOLE 550,000 0 0
NLS PHARMACEUTICS LTD *W EXP 09/25/202 H57830111 190 500,000 SH SOLE 500,000 0 0
NRX PHARMACEUTICALS INC COM 629444100 15,336 6,259,781 SH SOLE 6,259,781 0 0
OLAPLEX HLDGS INC COM 679369108 9,941 636,000 SH SOLE 636,000 0 0
ONION GLOBAL LTD SPONSORED ADS 68277G107 1,528 943,390 SH SOLE 943,390 0 0
ORTHO CLINICAL DIAGNOSTICS H ORD SHS G6829J107 62,026 3,324,000 SH SOLE 3,324,000 0 0
PACIRA BIOSCIENCES INC COM 695127100 39,992 524,000 SH SOLE 524,000 0 0
PASITHEA THERAPEUTICS CORP *W EXP 08/12/202 70261F111 170 1,000,000 SH SOLE 1,000,000 0 0
PETVIVO HLDGS INC *W EXP 08/13/202 716817119 66 200,000 SH SOLE 200,000 0 0
PILGRIMS PRIDE CORP COM 72147K108 7,530 300,000 SH SOLE 300,000 0 0
POLARITYTE INC COM 731094108 2,073 8,461,842 SH SOLE 8,461,842 0 0
POST HLDGS INC COM 737446104 44,049 636,000 SH SOLE 636,000 0 0
PTC THERAPEUTICS INC COM 69366J200 113,273 3,036,000 SH SOLE 3,036,000 0 0
RAIL VISION LTD *W EXP 03/27/202 M8186D114 828 1,089,500 SH SOLE 1,089,500 0 0
REGENERON PHARMACEUTICALS COM 75886F107 58,667 84,000 SH SOLE 84,000 0 0
REMARK HLDGS INC COM 75955K102 3,468 4,237,290 SH SOLE 4,237,290 0 0
RH COM 74967X103 16,276 49,913 SH SOLE 49,913 0 0
SEQLL INC *W EXP 08/31/202 81734C114 20 50,000 SH SOLE 50,000 0 0
SHIFTPIXY INC COM NEW 82452L203 2,223 2,850,000 SH SOLE 2,850,000 0 0
SIENTRA INC COM 82621J105 2,664 1,200,000 SH SOLE 1,200,000 0 0
SNOWFLAKE INC CL A 833445109 7,332 32,000 SH SOLE 32,000 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 1,083,936 24,000 SH Put SOLE 24,000 0 0
SPECTRUM BRANDS HLDGS INC NE COM 84790A105 10,646 120,000 SH SOLE 120,000 0 0
SPECTRUM PHARMACEUTICALS INC COM 84763A108 22,059 17,100,000 SH SOLE 17,100,000 0 0
SPLASH BEVERAGE GROUP INC *W EXP 06/15/202 84862C112 904 904,000 SH SOLE 904,000 0 0
STRAN & COMPANY INC *W EXP 11/01/202 86260J110 179 545,000 SH SOLE 545,000 0 0
STRYVE FOODS INC CLASS A COM 863685103 817 653,686 SH SOLE 653,686 0 0
SUNSHINE BIOPHARMA INC *W EXP 02/15/202 867781502 876 884,600 SH SOLE 884,600 0 0
SUNSHINE BIOPHARMA INC COM NEW 867781403 1,556 635,002 SH SOLE 635,002 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108 100,192 3,100,000 SH SOLE 3,100,000 0 0
TAPESTRY INC COM 876030107 2,883 77,594 SH SOLE 77,594 0 0
TARGET CORP COM 87612E106 68,271 321,698 SH SOLE 321,698 0 0
TC BIOPHARM HOLDINGS PLC *W EXP 02/08/202 87807D111 922 1,882,352 SH SOLE 1,882,352 0 0
TELA BIO INC COM 872381108 2,233 192,000 SH SOLE 192,000 0 0
TENAX THERAPEUTICS INC COM NEW 88032L209 1,635 2,019,995 SH SOLE 2,019,995 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 26,579 45,000 SH SOLE 45,000 0 0
TITAN PHARMACEUTICALS INC DE COM NEW 888314606 826 863,512 SH SOLE 863,512 0 0
TOAST INC CL A 888787108 28,771 1,324,000 SH SOLE 1,324,000 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 127,768 4,958,000 SH SOLE 4,958,000 0 0
U S GOLD CORP COM NEW 90291C201 2,860 408,627 SH SOLE 408,627 0 0
UBER TECHNOLOGIES INC COM 90353T100 44,100 1,236,000 SH SOLE 1,236,000 0 0
UPHEALTH INC *W EXP 06/08/202 91532B119 2 10,000 SH SOLE 10,000 0 0
VERASTEM INC COM 92337C104 2,820 2,000,000 SH SOLE 2,000,000 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 61,589 236,000 SH SOLE 236,000 0 0
VIATRIS INC COM 92556V106 63,104 5,800,000 SH SOLE 5,800,000 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 15,240 2,000,000 SH SOLE 2,000,000 0 0
WALMART INC COM 931142103 44,809 300,894 SH SOLE 300,894 0 0
WHOLE EARTH BRANDS INC COM CL A 96684W100 12,888 1,800,000 SH SOLE 1,800,000 0 0
WYNN RESORTS LTD COM 983134107 18,819 236,000 SH SOLE 236,000 0 0
XERIS BIOPHARMA HOLDINGS INC COM 98422E103 19,110 7,464,993 SH SOLE 7,464,993 0 0
ZYMEWORKS INC COM 98985W102 37,728 5,760,000 SH SOLE 5,760,000 0 0