The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F COVER PAGE

OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8

Report for the Calendar Year or Quarter Ended: 03-31-2022
Check here if Amendment   Amendment Number:
This Amendment (Check only one.):   is a restatement.
  adds new holdings entries.
Institutional Investment Manager Filing this Report:
Name: Nextech Invest AG
Address: Bahnhofstrasse 18
Zurich , V8CH-8001
Form 13F File Number: 028-22157

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

Person Signing this Report on Behalf of Reporting Manager:
Name: Marco Weibel
Title: Chief Financial Officer
Phone: 41-44-366-66-11
Signature, Place, and Date of Signing:
/s/ Marco Weibel Zurich , V8 05-16-2022
[Signature] [City, State] [Date]
Report Type (Check only one.):
X 13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager are reported in this report.)
  13F NOTICE. (Check here if no holdings reported are in this report, and all holdings are reported by other reporting manager(s).)
  13F COMBINATION REPORT. (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)
Form 13F Summary Page
Report Summary:
Number of Other Included Managers: 0
Form 13F Information Table Entry Total: 14
Form 13F Information Table Value Total: 350,279
(thousands)
List of Other Managers Reporting for this Manager:
[If there are no entries in this list, omit this section.]
Form 13F File Number Name

List of Other Included Managers:
Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.
[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]
No. Form 13F File Number Name


SEC FORM 13F-HR

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8

COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ARVINAS INC COM 04335A105 19,332 287,251 SH SOLE 287,251 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 12,024 188,228 SH SOLE 188,228 0 0
C4 THERAPEUTICS INC COM STK 12529R107 9,118 375,857 SH SOLE 375,857 0 0
CULLINAN ONCOLOGY INC COM 230031106 12,785 1,221,145 SH SOLE 1,221,145 0 0
EQRX INC COM 26886C107 54,121 13,104,424 SH SOLE 13,104,424 0 0
KINNATE BIOPHARMA INC COM 49705R105 33,873 3,008,243 SH SOLE 3,008,243 0 0
KRONOS BIO INC COM 50107A104 10,495 1,451,537 SH SOLE 1,451,537 0 0
MIRATI THERAPEUTICS INC COM 60468T105 14,249 173,300 SH SOLE 173,300 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 28,853 1,385,807 SH SOLE 1,385,807 0 0
RELAY THERAPEUTICS INC COM 75943R102 14,231 475,485 SH SOLE 475,485 0 0
REVOLUTION MEDICINES INC COM 76155X100 100,497 3,939,529 SH SOLE 3,939,529 0 0
SILVERBACK THERAPEUTICS INC COM 82835W108 6,704 1,910,029 SH SOLE 1,910,029 0 0
THESEUS PHARMACEUTICALS INC COM 88369M101 7,048 611,310 SH SOLE 611,310 0 0
TYRA BIOSCIENCES INC COM 90240B106 26,949 2,518,582 SH SOLE 2,518,582 0 0