The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F COVER PAGE

OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8

Report for the Calendar Year or Quarter Ended: 03-31-2022
Check here if Amendment   Amendment Number:
This Amendment (Check only one.):   is a restatement.
  adds new holdings entries.
Institutional Investment Manager Filing this Report:
Name: Logos Global Management LP
Address: 1 LETTERMAN DRIVE
BLDG C, SUITE C3-350
San Francisco , CA94129
Form 13F File Number: 028-20025

The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form.

Person Signing this Report on Behalf of Reporting Manager:
Name: Virginia Yee
Title: CFO/CCO
Phone: 415-801-4660
Signature, Place, and Date of Signing:
/s/ Virginia Yee San Francisco , CA 05-16-2022
[Signature] [City, State] [Date]
Report Type (Check only one.):
X 13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager are reported in this report.)
  13F NOTICE. (Check here if no holdings reported are in this report, and all holdings are reported by other reporting manager(s).)
  13F COMBINATION REPORT. (Check here if a portion of the holdings for this reporting manager are reported in this report and a portion are reported by other reporting manager(s).)
Form 13F Summary Page
Report Summary:
Number of Other Included Managers: 0
Form 13F Information Table Entry Total: 47
Form 13F Information Table Value Total: 771,303
(thousands)
List of Other Managers Reporting for this Manager:
[If there are no entries in this list, omit this section.]
Form 13F File Number Name

List of Other Included Managers:
Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional investment managers with respect to which this report is filed, other than the manager filing this report.
[If there are no entries in this list, state “NONE” and omit the column headings and list entries.]
No. Form 13F File Number Name


SEC FORM 13F-HR

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number: 3235-0006
Expires: July 31, 2015
Estimated average burden
hours per response: 23.8

COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ALX ONCOLOGY HLDGS INC COM 00166B105 50,892 3,011,352 SH SOLE 3,011,352 0 0
ANAPTYSBIO INC COM 032724106 7,422 300,000 SH SOLE 300,000 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 45,729 900,000 SH SOLE 900,000 0 0
ARCUTIS BIOTHERAPEUTICS INC COM 03969K108 28,890 1,500,000 SH SOLE 1,500,000 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 20,538 175,000 SH SOLE 175,000 0 0
ATHIRA PHARMA INC COM 04746L104 9,683 717,285 SH SOLE 717,285 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108 41,686 950,000 SH SOLE 950,000 0 0
BIOMEA FUSION INC COM 09077A106 892 200,000 SH SOLE 200,000 0 0
CENTESSA PHARMACEUTICALS PLC SPONSORED ADS 152309100 4,077 454,545 SH SOLE 454,545 0 0
CENTURY THERAPEUTICS INC COM 15673T100 6,928 550,259 SH SOLE 550,259 0 0
COGENT BIOSCIENCES INC COM 19240Q201 1,124 150,000 SH SOLE 150,000 0 0
CULLINAN ONCOLOGY INC COM 230031106 2,094 200,000 SH SOLE 200,000 0 0
CYTOKINETICS INC COM NEW 23282W605 59,448 1,615,000 SH SOLE 1,615,000 0 0
DESIGN THERAPEUTICS INC COM 25056L103 45,180 2,797,501 SH SOLE 2,797,501 0 0
DICE THERAPEUTICS INC COM 23345J104 26,500 1,385,251 SH SOLE 1,385,251 0 0
DYNE THERAPEUTICS INC COM 26818M108 26,360 2,734,392 SH SOLE 2,734,392 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105 2,073 213,744 SH SOLE 213,744 0 0
FULCRUM THERAPEUTICS INC COM 359616109 23,650 1,000,000 SH SOLE 1,000,000 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 43,300 1,250,000 SH SOLE 1,250,000 0 0
IDEAYA BIOSCIENCES INC COM 45166A102 31,892 2,850,000 SH SOLE 2,850,000 0 0
IKENA ONCOLOGY INC COM 45175G108 1,088 178,281 SH SOLE 178,281 0 0
INSTIL BIO INC COM 45783C101 4,054 377,091 SH SOLE 377,091 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 16,650 1,000,000 SH SOLE 1,000,000 0 0
IVERIC BIO INC COM 46583P102 30,294 1,800,000 SH SOLE 1,800,000 0 0
JOUNCE THERAPEUTICS INC COM 481116101 9,506 1,400,000 SH SOLE 1,400,000 0 0
KARUNA THERAPEUTICS INC COM 48576A100 43,109 340,000 SH SOLE 340,000 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 26,825 1,614,021 SH SOLE 1,614,021 0 0
LIANBIO SPONSORED ADS 53000N108 1,532 412,837 SH SOLE 412,837 0 0
MIRATI THERAPEUTICS INC COM 60468T105 28,777 350,000 SH SOLE 350,000 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 44,531 475,000 SH SOLE 475,000 0 0
NUVALENT INC COM 670703107 1,870 134,650 SH SOLE 134,650 0 0
NUVATION BIO INC *W EXP 07/07/202 67080N119 54 66,666 SH SOLE 66,666 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106 15,949 3,743,875 SH SOLE 3,743,875 0 0
OMEGA THERAPEUTICS INC COMMON STOCK 68217N105 81 12,986 SH SOLE 12,986 0 0
PYXIS ONCOLOGY INC COMMON STOCK 747324101 1,158 286,652 SH SOLE 286,652 0 0
RAIN THERAPEUTICS INC COM 75082Q105 680 134,194 SH SOLE 134,194 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103 8,701 675,000 SH SOLE 675,000 0 0
SOMALOGIC INC CLASS A COM 83444K105 802 100,000 SH SOLE 100,000 0 0
SPRUCE BIOSCIENCES INC COM 85209E109 2,010 1,000,000 SH SOLE 1,000,000 0 0
TALARIS THERAPEUTICS INC COM 87410C104 3,013 306,236 SH SOLE 306,236 0 0
TYRA BIOSCIENCES INC COM 90240B106 2,704 252,726 SH SOLE 252,726 0 0
VENTYX BIOSCIENCES INC COM 92332V107 34,119 2,514,280 SH SOLE 2,514,280 0 0
VERA THERAPEUTICS INC CL A 92337R101 9,044 385,000 SH SOLE 385,000 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 1,497 300,000 SH SOLE 300,000 0 0
VERVE THERAPEUTICS INC COM 92539P101 2,212 96,912 SH SOLE 96,912 0 0
VIGIL NEUROSCIENCE INC COM 92673K108 1,445 205,595 SH SOLE 205,595 0 0
VISTAGEN THERAPEUTICS INC COM NEW 92840H202 1,240 1,000,000 SH SOLE 1,000,000 0 0